Search Results - "Boeckx, Bram"

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling by Qian, Junbin, Olbrecht, Siel, Boeckx, Bram, Vos, Hanne, Laoui, Damya, Etlioglu, Emre, Wauters, Els, Pomella, Valentina, Verbandt, Sara, Busschaert, Pieter, Bassez, Ayse, Franken, Amelie, Bempt, Marlies Vanden, Xiong, Jieyi, Weynand, Birgit, van Herck, Yannick, Antoranz, Asier, Bosisio, Francesca Maria, Thienpont, Bernard, Floris, Giuseppe, Vergote, Ignace, Smeets, Ann, Tejpar, Sabine, Lambrechts, Diether

“…The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells, which are profoundly…”
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A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer by Bassez, Ayse, Vos, Hanne, Van Dyck, Laurien, Floris, Giuseppe, Arijs, Ingrid, Desmedt, Christine, Boeckx, Bram, Vanden Bempt, Marlies, Nevelsteen, Ines, Lambein, Kathleen, Punie, Kevin, Neven, Patrick, Garg, Abhishek D., Wildiers, Hans, Qian, Junbin, Smeets, Ann, Lambrechts, Diether

“…Immune-checkpoint blockade (ICB) combined with neoadjuvant chemotherapy improves pathological complete response in breast cancer. To understand why only a…”
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Phenotype molding of stromal cells in the lung tumor microenvironment by Lambrechts, Diether, Wauters, Els, Boeckx, Bram, Aibar, Sara, Nittner, David, Burton, Oliver, Bassez, Ayse, Decaluwé, Herbert, Pircher, Andreas, Van den Eynde, Kathleen, Weynand, Birgit, Verbeken, Erik, De Leyn, Paul, Liston, Adrian, Vansteenkiste, Johan, Carmeliet, Peter, Aerts, Stein, Thienpont, Bernard

“…Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of stromal cells. Here, we present a 52,698-cell catalog of the TME…”
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Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma by Nassar, Dany, Latil, Mathilde, Boeckx, Bram, Lambrechts, Diether, Blanpain, Cédric

“…Genomic profiling of carcinogen-induced skin tumors in mice provides a comprehensive characterization of their mutational landscape. Mouse models of cancers…”
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Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis by De Schepper, Sebastiaan, Verheijden, Simon, Aguilera-Lizarraga, Javier, Viola, Maria Francesca, Boesmans, Werend, Stakenborg, Nathalie, Voytyuk, Iryna, Schmidt, Inga, Boeckx, Bram, Dierckx de Casterlé, Isabelle, Baekelandt, Veerle, Gonzalez Dominguez, Erika, Mack, Matthias, Depoortere, Inge, De Strooper, Bart, Sprangers, Ben, Himmelreich, Uwe, Soenen, Stefaan, Guilliams, Martin, Vanden Berghe, Pieter, Jones, Elizabeth, Lambrechts, Diether, Boeckxstaens, Guy

“…Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety of tissue-supportive functions. The current paradigm dictates that…”
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Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals by Levine, Michelle S., Bakker, Bjorn, Boeckx, Bram, Moyett, Julia, Lu, James, Vitre, Benjamin, Spierings, Diana C., Lansdorp, Peter M., Cleveland, Don W., Lambrechts, Diether, Foijer, Floris, Holland, Andrew J.

“…Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of cancer remains unclear. Here, we test the…”
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Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages by Wauters, Els, Van Mol, Pierre, Garg, Abhishek Dinkarnath, Jansen, Sander, Van Herck, Yannick, Vanderbeke, Lore, Bassez, Ayse, Boeckx, Bram, Malengier-Devlies, Bert, Timmerman, Anna, Van Brussel, Thomas, Van Buyten, Tina, Schepers, Rogier, Heylen, Elisabeth, Dauwe, Dieter, Dooms, Christophe, Gunst, Jan, Hermans, Greet, Meersseman, Philippe, Testelmans, Dries, Yserbyt, Jonas, Tejpar, Sabine, De Wever, Walter, Matthys, Patrick, Neyts, Johan, Wauters, Joost, Qian, Junbin, Lambrechts, Diether

“…How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell…”
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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy by Cantelmo, Anna Rita, Conradi, Lena-Christin, Brajic, Aleksandra, Goveia, Jermaine, Kalucka, Joanna, Pircher, Andreas, Chaturvedi, Pallavi, Hol, Johanna, Thienpont, Bernard, Teuwen, Laure-Anne, Schoors, Sandra, Boeckx, Bram, Vriens, Joris, Kuchnio, Anna, Veys, Koen, Cruys, Bert, Finotto, Lise, Treps, Lucas, Stav-Noraas, Tor Espen, Bifari, Francesco, Stapor, Peter, Decimo, Ilaria, Kampen, Kim, De Bock, Katrien, Haraldsen, Guttorm, Schoonjans, Luc, Rabelink, Ton, Eelen, Guy, Ghesquière, Bart, Rehman, Jalees, Lambrechts, Diether, Malik, Asrar B., Dewerchin, Mieke, Carmeliet, Peter

“…Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as an anti-cancer treatment. Here, we…”
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Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching by De Smedt, Linde, Palmans, Sofie, Andel, Daan, Govaere, Olivier, Boeckx, Bram, Smeets, Dominiek, Galle, Eva, Wouters, Jasper, Barras, David, Suffiotti, Madeleine, Dekervel, Jeroen, Tousseyn, Thomas, De Hertogh, Gert, Prenen, Hans, Tejpar, Sabine, Lambrechts, Diether, Sagaert, Xavier

“…Background: Tumour budding, described as the presence of single cells or small clusters of up to five tumour cells at the invasive margin, is established as a…”
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Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy by Van Hove, Inge, De Groef, Lies, Boeckx, Bram, Modave, Elodie, Hu, Tjing-Tjing, Beets, Karen, Etienne, Isabelle, Van Bergen, Tine, Lambrechts, Diether, Moons, Lieve, Feyen, Jean H. M., Porcu, Michaël

“…Aims/hypothesis Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our…”
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Lineage-specific functions of TET1 in the postimplantation mouse embryo by Khoueiry, Rita, Sohni, Abhishek, Thienpont, Bernard, Luo, Xinlong, Velde, Joris Vande, Bartoccetti, Michela, Boeckx, Bram, Zwijsen, An, Rao, Anjana, Lambrechts, Diether, Koh, Kian Peng

“…Kian Peng Koh and colleagues report that TET1 regulates lineage-specific genes in the mouse postimplantation embryo, many of them independently of DNA…”
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PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma by Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

“…The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable…”
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The genomic landscape of nonsmall cell lung carcinoma in never smokers by Boeckx, Bram, Shahi, Rajendra B., Smeets, Dominiek, De Brakeleer, Sylvia, Decoster, Lore, Van Brussel, Thomas, Galdermans, Daniella, Vercauter, Piet, Decoster, Lynn, Alexander, Patrick, Berchem, Guy, Ocak, Sebahat, Vuylsteke, Peter, Deschepper, Koen, Lambrechts, Marc, Cappoen, Nadia, Teugels, Erik, Lambrechts, Diether, De Greve, Jacques

“…Lung cancer is the number one cause of cancer‐related death worldwide with cigarette smoking as its major risk factor. Although the incidence of lung cancer in…”
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The conformational behavior and H-bond structure of asparagine: A theoretical and experimental matrix-isolation FT-IR study by Boeckx, Bram, Maes, Guido

“…Due to the high importance of the structural properties of peptides, the conformational behavior of one of their elementary building blocks, asparagine, has…”
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Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function by Craps, Sander, Van Wauwe, Jore, De Moudt, Sofie, De Munck, Dorien, Leloup, Arthur J.A., Boeckx, Bram, Vervliet, Tim, Dheedene, Wouter, Criem, Nathan, Geeroms, Carla, Jones, Elizabeth A.V., Zwijsen, An, Lambrechts, Diether, Fransen, Paul, Beerens, Manu, Luttun, Aernout

“…[Figure: see text]…”
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Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition by Öner, Deniz, Ghosh, Manosij, Bové, Hannelore, Moisse, Matthieu, Boeckx, Bram, Duca, Radu C, Poels, Katrien, Luyts, Katrien, Putzeys, Eveline, Van Landuydt, Kirsten, Vanoirbeek, Jeroen Aj, Ameloot, Marcel, Lambrechts, Diether, Godderis, Lode, Hoet, Peter Hm

“…Subtle DNA methylation alterations mediated by carbon nanotubes (CNTs) exposure might contribute to pathogenesis and disease susceptibility. It is known that…”
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Simulating the Interaction between Amino Acids and DNA: A Combined Matrix-Isolation FT-IR and Theoretical Study of the 1‑Methyluracil·Glycine H‑Bond Complexes Using a Dual Sublimation Furnace by Boeckx, Bram, Maes, Guido

“…The H-bond complex formation between 1-methyluracil and glycine has been investigated by theoretical calculations and the most stable complex configurations…”
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A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer by Kreuzinger, Caroline, Geroldinger, Angelika, Smeets, Dominiek, Braicu, Elena Ioana, Sehouli, Jalid, Koller, Julia, Wolf, Andrea, Darb-Esfahani, Silvia, Joehrens, Korinna, Vergote, Ignace, Vanderstichele, Adriaan, Boeckx, Bram, Lambrechts, Diether, Gabra, Hani, Wisman, G Bea A, Trillsch, Fabian, Heinze, Georg, Horvat, Reinhard, Polterauer, Stephan, Berns, Els, Theillet, Charles, Cacsire Castillo-Tong, Dan

“…Most high-grade serous ovarian cancer (HGSOC) patients develop recurrent disease after first-line treatment, frequently with fatal outcome. This work aims at…”
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Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates by Malengier-Devlies, Bert, Filtjens, Jessica, Ahmadzadeh, Kourosh, Boeckx, Bram, Vandenhaute, Jessica, De Visscher, Amber, Bernaerts, Eline, Mitera, Tania, Jacobs, Cato, Vanderbeke, Lore, Van Mol, Pierre, Van Herck, Yannick, Hermans, Greet, Meersseman, Philippe, Wilmer, Alexander, Gouwy, Mieke, Garg, Abhishek D., Humblet-Baron, Stephanie, De Smet, Frederik, Martinod, Kimberly, Wauters, Els, Proost, Paul, Wouters, Carine, Leclercq, Georges, Lambrechts, Diether, Wauters, Joost, Matthys, Patrick

“…COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural killer (NK) cells play an important role in innate immune…”
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Correlation of Immunological and Molecular Profiles with Response to Crizotinib in Alveolar Soft Part Sarcoma: An Exploratory Study Related to the EORTC 90101 "CREATE" Trial by Lee, Che-Jui, Modave, Elodie, Boeckx, Bram, Kasper, Bernd, Aamdal, Steinar, Leahy, Michael G, Rutkowski, Piotr, Bauer, Sebastian, Debiec-Rychter, Maria, Sciot, Raf, Lambrechts, Diether, Wozniak, Agnieszka, Schöffski, Patrick

“…Alveolar soft part sarcoma (ASPS) is a rare subtype of soft tissue sarcoma characterized by an unbalanced translocation, resulting in ASPSCR1-TFE3 fusion that…”
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