Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation

Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation

Osteoporosis research undertaken in males is rare and there are only a few therapeutic options. Phytoestrogens might be a safe alternative for prophylaxis. Sixty 3-month-old male rats were orchidectomized and divided into five groups. The groups either received soy-free food (C), estradiol (E), test...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research Vol. 23; no. 6; pp. 851 - 858
Main Authors: Sehmisch, S, Boeckhoff, J, Wille, J, Seidlova-Wuttke, D, Rack, T, Tezval, M, Wuttke, W, Stuermer, K.M, Stuermer, E.K
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01-06-2009
Wiley
Subjects:
Animals
Biological and medical sciences
Biomechanical Phenomena
biomechanical testing
Bone Density - drug effects
Bone Density Conservation Agents - pharmacology
Estradiol - pharmacology
General pharmacology
Male
male osteoporosis
Medical sciences
Orchiectomy
Osteoporosis - prevention & control
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytoestrogens - pharmacology
phytohormones
Phytotherapy
Rats
Rats, Sprague-Dawley
Tensile Strength
Testosterone - pharmacology
Tibia - drug effects
Vitex
Vitex - chemistry
Vitex agnus castus
Vitex agnus castus
Rat
Diseases of the osteoarticular system
Estrogen
Male
Estradiol
Medicinal plant
male osteoporosis
Prevention
Osteoporosis
Dicotyledones
Angiospermae
biomechanical testing
Plant growth substance
Testicular hormone
Supplementation
Osteopenia
phytohormones
Androgen
Pharmacognosy
Rodentia
Ovarian hormone
Testosterone
Vertebrata
Mammalia
Verbenaceae
Animal
Plant origin
Spermatophyta
Phytohormone
Sex steroid hormone
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoporosis research undertaken in males is rare and there are only a few therapeutic options. Phytoestrogens might be a safe alternative for prophylaxis. Sixty 3-month-old male rats were orchidectomized and divided into five groups. The groups either received soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks. The tibia metaphysis was tested biomechanically and histomorphometrically.The AC high group reached 87% of the biomechanical values of the estradiol group and was significantly superior to the control group. Testosterone supplementation resulted in poor biomechanical properties. The cortical bone parameters of the AC group were similar to the control group, while supplementation with estradiol and testosterone demonstrated a reduction of cortical bone. The AC high group reached 88.4% of trabecular bone area, 80.7% of trabecular number and 66.9% of the number of trabecular nodes compared with estradiol supplementation.Vitex agnus castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT. Testosterone supplementation has positive effects on trabecular bone, which are concurrently counteracted by the loss of cortical bone. Copyright © 2008 John Wiley & Sons, Ltd.
Bibliography:http://dx.doi.org/10.1002/ptr.2711
istex:ACDF76126453E54AD358C4088B268D5F24D239C6
ArticleID:PTR2711
ark:/67375/WNG-SF3QKRDP-8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2711