Search Results - "Boe, Alessandra"

Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma by Haas, Tobias L., Sciuto, Maria Rita, Brunetto, Lidia, Valvo, Cecilia, Signore, Michele, Fiori, Micol E., di Martino, Simona, Giannetti, Stefano, Morgante, Liliana, Boe, Alessandra, Patrizii, Michele, Warnken, Uwe, Schnölzer, Martina, Ciolfi, Andrea, Di Stefano, Chiara, Biffoni, Mauro, Ricci-Vitiani, Lucia, Pallini, Roberto, De Maria, Ruggero

“…Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used…”
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Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth by Buccarelli, Mariachiara, D'Alessandris, Quintino Giorgio, Matarrese, Paola, Mollinari, Cristiana, Signore, Michele, Cappannini, Andrea, Martini, Maurizio, D'Aliberti, Pierluigi, De Luca, Gabriele, Pedini, Francesca, Boe, Alessandra, Biffoni, Mauro, Pallini, Roberto, Ricci-Vitiani, Lucia

“…Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, characterized by a poor prognosis mainly due to recurrence and…”
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miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2 by Villanova, Lidia, Barbini, Chiara, Piccolo, Cristina, Boe, Alessandra, De Maria, Ruggero, Fiori, Micol Eleonora

“…MicroRNAs are tiny but powerful regulators of gene expression at the post-transcriptional level. Aberrant expression of oncogenic and tumor-suppressor…”
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An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile by De Angelis, Maria Laura, Francescangeli, Federica, Nicolazzo, Chiara, Signore, Michele, Giuliani, Alessandro, Colace, Lidia, Boe, Alessandra, Magri, Valentina, Baiocchi, Marta, Ciardi, Antonio, Scarola, Francesco, Spada, Massimo, La Torre, Filippo, Gazzaniga, Paola, Biffoni, Mauro, De Maria, Ruggero, Zeuner, Ann

“…Circulating tumor cells (CTCs) are responsible for the metastatic dissemination of colorectal cancer (CRC) to the liver, lungs and lymph nodes. CTCs rarity and…”
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Mir-370-3p Impairs Glioblastoma Stem-Like Cell Malignancy Regulating a Complex Interplay between HMGA2/HIF1A and the Oncogenic Long Non-Coding RNA (lncRNA) NEAT1 by Lulli, Valentina, Buccarelli, Mariachiara, Ilari, Ramona, Castellani, Giorgia, De Dominicis, Chiara, Di Giamberardino, Alessandra, D Alessandris, Quintino Giorgio, Giannetti, Stefano, Martini, Maurizio, Stumpo, Vittorio, Boe, Alessandra, De Luca, Gabriele, Biffoni, Mauro, Marziali, Giovanna, Pallini, Roberto, Ricci-Vitiani, Lucia

“…Glioblastoma (GBM) is the most aggressive and prevalent form of a human brain tumor in adults. Several data have demonstrated the implication of microRNAs…”
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A pre-existing population of ZEB2 + quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer by Francescangeli, Federica, Contavalli, Paola, De Angelis, Maria Laura, Careccia, Silvia, Signore, Michele, Haas, Tobias Longin, Salaris, Federico, Baiocchi, Marta, Boe, Alessandra, Giuliani, Alessandro, Tcheremenskaia, Olga, Pagliuca, Alfredo, Guardiola, Ombretta, Minchiotti, Gabriella, Colace, Lidia, Ciardi, Antonio, D'Andrea, Vito, La Torre, Filippo, Medema, JanPaul, De Maria, Ruggero, Zeuner, Ann

“…Quiescent/slow cycling cells have been identified in several tumors and correlated with therapy resistance. However, the features of chemoresistant populations…”
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A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice by De Angelis, Maria Laura, Francescangeli, Federica, Aricò, Eleonora, Verachi, Paola, Zucchetti, Massimo, Matteo, Cristina, Petricci, Elena, Pilozzi, Emanuela, Orienti, Isabella, Boe, Alessandra, Eramo, Adriana, Rossi, Rachele, Corati, Tiberio, Macchia, Daniele, Pacca, Anna Maria, Zeuner, Ann, Baiocchi, Marta

“…Abstract Background Prevention and treatment of metastatic breast cancer (BC) is an unmet clinical need. The retinoic acid derivative fenretinide (FeR) was…”
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Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment by Castellani, Giorgia, Buccarelli, Mariachiara, D'Alessandris, Quintino Giorgio, Ilari, Ramona, Cappannini, Andrea, Pedini, Francesca, Boe, Alessandra, Lulli, Valentina, Parolini, Isabella, Giannetti, Stefano, Biffoni, Mauro, Zappavigna, Vincenzo, Marziali, Giovanna, Pallini, Roberto, Ricci-Vitiani, Lucia

“…Glioblastoma (GBM) is the most lethal primary brain tumor in adult, characterized by highly aggressive and infiltrative growth. The current therapeutic…”
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MiR-378a-3p Acts as a Tumor Suppressor in Colorectal Cancer Stem-Like Cells and Affects the Expression of MALAT1 and NEAT1 lncRNAs by Castellani, Giorgia, Buccarelli, Mariachiara, Lulli, Valentina, Ilari, Ramona, De Luca, Gabriele, Pedini, Francesca, Boe, Alessandra, Felli, Nadia, Biffoni, Mauro, Pilozzi, Emanuela, Marziali, Giovanna, Ricci-Vitiani, Lucia

“…MiR-378a-3p plays a critical role in carcinogenesis acting as a tumor suppressor, promoting apoptosis and cell cycle arrest and reducing invasion and drug…”
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The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR‐221&222‐c‐FOS pathway by Errico, M. Cristina, Felicetti, Federica, Bottero, Lisabianca, Mattia, Gianfranco, Boe, Alessandra, Felli, Nadia, Petrini, Marina, Bellenghi, Maria, Pandha, Hardev S., Calvaruso, Marco, Tripodo, Claudio, Colombo, Mario P., Morgan, Richard, Carè, Alessandra

“…Cutaneous melanoma is the fastest increasing cancer worldwide. Although several molecular abnormalities have been associated with melanoma progression, the…”
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CRIPTO Is a Marker of Chemotherapy-Induced Stem Cell Expansion in Non-Small Cell Lung Cancer by Francescangeli, Federica, De Angelis, Maria Laura, Rossi, Rachele, Sette, Giovanni, Eramo, Adriana, Boe, Alessandra, Guardiola, Ombretta, Tang, Tao, Yu, Shi-Cang, Minchiotti, Gabriella, Zeuner, Ann

“…Chemotherapy is the mainstay for the treatment of non-small cell lung cancer (NSCLC). However, NSCLC cells are either intrinsically chemoresistant or rapidly…”
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Joint action of miR‐126 and MAPK/PI3K inhibitors against metastatic melanoma by Pedini, Francesca, De Luca, Gabriele, Felicetti, Federica, Puglisi, Rossella, Boe, Alessandra, Arasi, Maria Beatrice, Fratini, Federica, Mattia, Gianfranco, Spada, Massimo, Caporali, Simona, Biffoni, Mauro, Giuliani, Alessandro, Carè, Alessandra, Felli, Nadia

“…Emerging data support the rationale of combined therapies in advanced melanoma. Specifically, the combined use of drugs with different mechanisms of action can…”
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Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines by Calzolari, Alessia, Saulle, Ernestina, De Angelis, Maria Laura, Pasquini, Luca, Boe, Alessandra, Pelacchi, Federica, Ricci-Vitiani, Lucia, Baiocchi, Marta, Testa, Ugo

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to exhibit therapeutic activity in cancer. However, many tumors remain…”
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Identification of β-Dystrobrevin as a Direct Target of miR-143: Involvement in Early Stages of Neural Differentiation by Quaranta, Maria Teresa, Spinello, Isabella, Paolillo, Rosa, Macchia, Gianfranco, Boe, Alessandra, Ceccarini, Marina, Labbaye, Catherine, Macioce, Pompeo

“…Duchenne Muscular Dystrophy, a genetic disorder that results in a gradual breakdown of muscle, is associated to mild to severe cognitive impairment in about…”
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The Ultrastructural Analysis of Human Colorectal Cancer Stem Cell-Derived Spheroids and Their Mouse Xenograft Shows That the Same Cells Types Have Different Ratios by Relucenti, Michela, Francescangeli, Federica, De Angelis, Maria Laura, D’Andrea, Vito, Miglietta, Selenia, Pilozzi, Emanuela, Li, Xiaobo, Boe, Alessandra, Chen, Rui, Zeuner, Ann, Familiari, Giuseppe

“…Spheroids from primary colorectal cancer cells and their mice xenografts have emerged as useful preclinical models for cancer research as they replicate tumor…”
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Cancer Stem Cell‐Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy Resistance by De Angelis, Maria Laura, Zeuner, Ann, Policicchio, Eleonora, Russo, Giorgio, Bruselles, Alessandro, Signore, Michele, Vitale, Sara, De Luca, Gabriele, Pilozzi, Emanuela, Boe, Alessandra, Stassi, Giorgio, Ricci-Vitiani, Lucia, Amoreo, Carla Azzurra, Pagliuca, Alfredo, Francescangeli, Federica, Tartaglia, Marco, De Maria, Ruggero, Baiocchi, Marta

“…Colorectal cancer stem cell (CSC)‐enriched cultures were obtained efficiently from primary tumor specimens by optimizing a CSC‐isolation protocol. Based on in…”
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Transferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas by Calzolari, Alessia, Larocca, Luigi Maria, Deaglio, Silvia, Finisguerra, Veronica, Boe, Alessandra, Raggi, Carla, Ricci-Vitani, Lucia, Pierconti, Francesco, Malavasi, Fabio, De Maria, Ruggero, Testa, Ugo, Pallini, Roberto

“…Under physiological conditions, transferrin receptor 2 (TfR2) is expressed in the liver and its balance is related to the cell cycle rather than to…”
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Transcriptional silencing of the ETS1 oncogene contributes to human granulocytic differentiation by LULLI, Valentina, ROMANIA, Paolo, RICCIONI, Roberta, BOE, Alessandra, LO-COCO, Francesco, TESTA, Ugo, MARZIALI, Giovanna

“…Ets-1 is a widely expressed transcription factor implicated in several biological processes including hematopoiesis, where it contributes to the regulation of…”
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Saposin B binds and transfers phospholipids by Ciaffoni, Fiorella, Tatti, Massimo, Boe, Alessandra, Salvioli, Rosa, Fluharty, Arvan, Sonnino, Sandro, Vaccaro, Anna Maria

“…Saposin B (Sap B) is a member of a family of four small glycoproteins, Sap A, B, C, and D. Like the other three saposins, Sap B plays a physiological role in…”
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INTERLEUKIN 6 KNOCK-OUT MICE ARE RESISTANT TO ANTIGEN-INDUCED EXPERIMENTAL ARTHRITIS by Boe, Alessandra, Baiocchi, Marta, Carbonatto, Michela, Papoian, Ruben, Serlupi-Crescenzi, Ottaviano

“…In order to assess the potential role of IL-6 in rheumatoid arthritis (RA), we have compared IL-6 deficient (IL-6 ko) mice and their wild-type (wt) counterpart…”
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