Search Results - "Bodner, Micah J."

Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models by Siboni, Ruth B, Bodner, Micah J, Khalifa, Muhammad M, Docter, Aaron G, Choi, Jessica Y, Nakamori, Masayuki, Haley, Michael M, Berglund, J. Andrew

“…Myotonic dystrophy type 1 (DM1) is a disease characterized by errors in alternative splicing, or “mis-splicing”. The causative agent of mis-splicing in DM1 is…”
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Synthesis of N-substituted aryl amidines by strong base activation of amines by Khalifa, Muhammad M., Bodner, Micah J., Berglund, J. Andrew, Haley, Michael M.

“…[Display omitted] We describe an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The protocol…”
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Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis by Freeman, Michael F, Moshos, Kristos A, Bodner, Micah J, Li, Rongfeng, Townsend, Craig A

“…The enzymatic activities of three proteins encoded by the thienamycin gene cluster of Streptomyces cattleya (ThnR, ThnH, and ThnT) have been shown to…”
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Reducing Levels of Toxic RNA with Small Molecules by Coonrod, Leslie A, Nakamori, Masayuki, Wang, Wenli, Carrell, Samuel, Hilton, Cameron L, Bodner, Micah J, Siboni, Ruth B, Docter, Aaron G, Haley, Michael M, Thornton, Charles A, Berglund, J. Andrew

“…Myotonic dystrophy (DM) is one of the most common forms of muscular dystrophy. DM is an autosomal dominant disease caused by a toxic gain of function RNA. The…”
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Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics by Bodner, Micah J, Phelan, Ryan M, Freeman, Michael F, Li, Rongfeng, Townsend, Craig A

“…Carbapenems are a clinically important antibiotic family. More than 50 naturally occurring carbapenam/ems are known and are distinguished primarily by their…”
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Definition of the Common and Divergent Steps in Carbapenem β-Lactam Antibiotic Biosynthesis by Bodner, Micah J., Li, Rongfeng, Phelan, Ryan M., Freeman, Michael F., Moshos, Kristos A., Lloyd, Evan P., Townsend, Craig A.

“…Approximately 50 naturally occurring carbapenem β‐lactam antibiotics are known. All but one of these have been isolated from Streptomyces species and are…”
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A Catalytic Asymmetric Route to Carbapenems by Bodner, Micah J, Phelan, Ryan M, Townsend, Craig A

“…Efficient syntheses of N-acetyl thienamycin and epithienamycin A in their readily deprotected form are reported where three contiguous stereocenters are…”
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