Search Results - "Bodmer, W"

5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency by Bracht, K, Nicholls, A M, Liu, Y, Bodmer, W F

“…Background: Colorectal cancer is (CRC) one of the commonest cancers and its therapy is still based on few drugs. Currently, no biological criteria are used to…”
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A Haldane perspective from a Fisher student by Bodmer, W. F.

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High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease by Thornalley, P. J, Babaei-Jadidi, R, Al Ali, H, Rabbani, N, Antonysunil, A, Larkin, J, Ahmed, A, Rayman, G, Bodmer, C. W

“…Aims/hypothesis To assess thiamine status by analysis of plasma, erythrocytes and urine in type 1 and type 2 diabetic patients and links to markers of vascular…”
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Epigenetic control of CD24 expression in colorectal cancer by Ayub, M, Bodmer, W

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Myofibroblast activation in colorectal cancer lymph node metastases by Yeung, T M, Buskens, C, Wang, L M, Mortensen, N J, Bodmer, W F

“…Background: Myofibroblasts have an important role in regulating the normal colorectal stem cell niche. While the activation of myofibroblasts in primary…”
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Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscope by Ntouroupi, T G, Ashraf, S Q, McGregor, S B, Turney, B W, Seppo, A, Kim, Y, Wang, X, Kilpatrick, M W, Tsipouras, P, Tafas, T, Bodmer, W F

“…We have developed an automated, highly sensitive and specific method for identifying and enumerating circulating tumour cells (CTCs) in the blood. Blood…”
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APC Mutations in Sporadic Colorectal Tumors: A Mutational "Hotspot" and Interdependence of the "Two Hits" by Rowan, A. J., Lamlum, H., Ilyas, M., Wheeler, J., Straub, J., Papadopoulou, A., Bicknell, D., Bodmer, W. F., Tomlinson, I. P. M.

“…Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a comprehensive analysis by screening the whole gene for…”
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Target Genes of β -catenin-T Cell-Factor/Lymphoid-Enhancer-Factor Signaling in Human Colorectal Carcinomas by Mann, B., Gelos, M., Siedow, A., Hanski, M. L., Gratchev, A., Ilyas, M., Bodmer, W. F., Moyer, M. P., Riecken, E. O., Buhr, H. J., Hanski, C.

“…Mutations in the adenomatous polyposis coli or β -catenin gene lead to cytosolic accumulation of β -catenin and, subsequently, to increased transcriptional…”
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DNA mismatch repair genes and colorectal cancer by WHEELER, J M D, BODMER, W F, MORTENSEN, N J McC

“…Mutations in hMSH2 and hMLH1 account for the majority of reported HNPCC cases, 15 although two additional homologues of the mutL gene (hPMS1 on chromosome 2q…”
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The Mutation Rate and Cancer by Tomlinson, I. P. M., Novelli, M. R., Bodmer, W. F.

“…The selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is therefore a form of evolution at the somatic level, in which the…”
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β -Catenin Mutations in Cell Lines Established from Human Colorectal Cancers by Ilyas, M., Tomlinson, I. P. M., Rowan, A., Pignatelli, M., Bodmer, W. F.

“…β -catenin has functions as both an adhesion and a signaling molecule. Disruption of these functions through mutations of the β -catenin gene (CTNNB1) may be…”
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Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog by Tomlinson, Ian, Bodmer, Walter

“…In considering tumorigenesis, much attention is paid to genome instability and mutation rates. While reflecting on the circumstances that have led to this…”
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CDX1 Is an Important Molecular Mediator of Barrett's Metaplasia by N. A. C. S. Wong, Wilding, J., Bartlett, S., Liu, Y., Warren, B. F., Piris, J., Maynard, N., Marshall, R., Bodmer, W. F.

“…The molecular pathogenesis of Barrett's metaplasia (BM) of the esophagus is poorly understood. The change to an intestinal phenotype occurs on a background of…”
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Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer by Wheeler, J M D, Kim, H C, Efstathiou, J A, Ilyas, M, Mortensen, N J McC, Bodmer, W F

“…BACKGROUND Ulcerative colitis associated colorectal cancer (UCACRC) has several distinctive clinicopathological and genetic features which differ from sporadic…”
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SMAD4 Mutations in Colorectal Cancer Probably Occur before Chromosomal Instability, but after Divergence of the Microsatellite Instability Pathway by Woodford-Richens, K. L., Rowan, A. J., Gorman, P., Halford, S., Bicknell, D. C., Wasan, H. S., Roylance, R. R., Bodmer, W. F., Tomlinson, I. P. M.

“…Loss of chromosome 18q21 is well documented in colorectal cancer, and it has been suggested that this loss targets the DCC, DPC4/SMAD4, and SMAD2 genes…”
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Genetic pathways in colorectal and other cancers by Ilyas, M., Straub, J., Tomlinson, I.P.M., Bodmer, W.F.

“…Cells from cancers show aberrant behaviour such as unrestrained growth, invasion into adjacent tissue and metastasis. All these features of cancer cell…”
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An insight into the genetic pathway of adenocarcinoma of the small intestine by Wheeler, J M D, Warren, B F, Mortensen, N J McC, Kim, H C, Biddolph, S C, Elia, G, Beck, N E, Williams, G T, Shepherd, N A, Bateman, A C, Bodmer, W F

“…Background: Although the adenoma to carcinoma pathway in colorectal cancer is well described, the mechanisms of carcinogenesis in the small intestine remain…”
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The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers by WHEELER, J. M. D, LOUKOLA, A, AALTONEN, L. A, MORTENSEN, N. J. M, BODMER, W. F

“…Hypermethylation of the promoter region of the hMLH1 gene is associated with absent expression of MLH1 protein in sporadic colorectal cancers with…”
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An Ancestral Ashkenazi Haplotype at the HMPS/CRAC1 Locus on 15q13–q14 Is Associated with Hereditary Mixed Polyposis Syndrome by Jaeger, E.E.M., Woodford-Richens, K.L., Lockett, M., Rowan, A.J., Sawyer, E.J., Heinimann, K., Rozen, P., Murday, V.A., Whitelaw, S.C., Ginsberg, A., Atkin, W.S., Lynch, H.T., Southey, M.C., Debinski, H., Eng, C., Bodmer, W.F., Talbot, I.C., Hodgson, S.V., Thomas, H.J.W., Tomlinson, I.P.M.

“…The putative locus for hereditary mixed polyposis syndrome (HMPS) in a large family of Ashkenazi descent (SM96) was previously reported to map to chromosome…”
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Analysis of genetic and phenotypic heterogeneity in juvenile polyposis by Woodford-Richens, K, Bevan, S, Churchman, M, Dowling, B, Jones, D, Norbury, C G, Hodgson, S V, Desai, D, Neale, K, Phillips, R K S, Young, J, Leggett, B, Dunlop, M, Rozen, P, Eng, C, Markie, D, Rodriguez-Bigas, M A, Sheridan, E, Iwama, T, Eccles, D, Smith, G T, Kim, J C, Kim, K M, Sampson, J R, Evans, G, Tejpar, S, Bodmer, W F, Tomlinson, I P M, Houlston, R S

“…BACKGROUND Juvenile polyposis syndrome (JPS) is characterised by gastrointestinal (GI) hamartomatous polyposis and an increased risk of GI malignancy. Juvenile…”
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