Search Results - "Bodmer, Bianca S."

TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction by Galão, Rui Pedro, Wilson, Harry, Schierhorn, Kristina L, Debeljak, Franka, Bodmer, Bianca S, Goldhill, Daniel, Hoenen, Thomas, Wilson, Sam J, Swanson, Chad M, Neil, Stuart J D

“…Ebola virus (EBOV) causes highly pathogenic disease in primates. Through screening a library of human interferon-stimulated genes (ISGs), we identified TRIM25…”
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Assessment of Life Cycle Modeling Systems as Prediction Tools for a Possible Attenuation of Recombinant Ebola Viruses by Bodmer, Bianca S, Hoenen, Thomas

“…Ebola virus (EBOV) causes hemorrhagic fever in humans with high case fatality rates. In the past, a number of recombinant EBOVs expressing different reporters…”
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Evidence for Viral mRNA Export from Ebola Virus Inclusion Bodies by the Nuclear RNA Export Factor NXF1 by Wendt, Lisa, Brandt, Janine, Ushakov, Dmitry S, Bodmer, Bianca S, Pickin, Matthew J, Groseth, Allison, Hoenen, Thomas

“…Many negative-sense RNA viruses, including the highly pathogenic Ebola virus (EBOV), use cytoplasmic inclusion bodies (IBs) for viral RNA synthesis. However,…”
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Ebola virus inclusion bodies are liquid organelles whose formation is facilitated by nucleoprotein oligomerization by Bodmer, Bianca S., Vallbracht, Melina, Ushakov, Dmitry S., Wendt, Lisa, Chlanda, Petr, Hoenen, Thomas

“…Viral RNA synthesis of several non-segmented, negative-sense RNA viruses (NNSVs) takes place in inclusion bodies (IBs) that show properties of liquid…”
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The Ebola Virus Nucleoprotein Recruits the Nuclear RNA Export Factor NXF1 into Inclusion Bodies to Facilitate Viral Protein Expression by Wendt, Lisa, Brandt, Janine, Bodmer, Bianca S, Reiche, Sven, Schmidt, Marie Luisa, Traeger, Shelby, Hoenen, Thomas

“…Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is…”
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The Cellular Protein CAD is Recruited into Ebola Virus Inclusion Bodies by the Nucleoprotein NP to Facilitate Genome Replication and Transcription by Brandt, Janine, Wendt, Lisa, Bodmer, Bianca S, Mettenleiter, Thomas C, Hoenen, Thomas

“…Ebola virus (EBOV) is a zoonotic pathogen causing severe hemorrhagic fevers in humans and non-human primates with high case fatality rates. In recent years,…”
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N6-methyladenosine is required for efficient RNA synthesis of Ebola virus and other haemorrhagic fever viruses by Wendt, Lisa, Pickin, Matthew J., Bodmer, Bianca S., Reiche, Sven, Fénéant, Lucie, Hölper, Julia E., Fuchs, Walter, Groseth, Allison, Hoenen, Thomas

“…N 6 -methyladenosine (m 6 A) is one of the most abundant modifications of cellular RNA, where it serves various functions. m 6 A methylation of many viral RNA…”
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A protective measles virus-derived vaccine inducing long-lasting immune responses against influenza A virus H7N9 by Hörner, Cindy, Fiedler, Anna H., Bodmer, Bianca S., Walz, Lisa, Scheuplein, Vivian A., Hutzler, Stefan, Matrosovich, Mikhail N., von Messling, Veronika, Mühlebach, Michael D.

“…A novel Influenza A virus (subtype H7N9) emerged in spring 2013 and caused considerable mortality in zoonotically infected patients. To be prepared for…”
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Differences in Viral RNA Synthesis but Not Budding or Entry Contribute to the In Vitro Attenuation of Reston Virus Compared to Ebola Virus by Bodmer, Bianca S, Greßler, Josephin, Schmidt, Marie L, Holzerland, Julia, Brandt, Janine, Braun, Stefanie, Groseth, Allison, Hoenen, Thomas

“…Most filoviruses cause severe disease in humans. For example, Ebola virus (EBOV) is responsible for the two most extensive outbreaks of filovirus disease to…”
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Molecular insights into the Ebola virus life cycle by Bodmer, Bianca S., Hoenen, Thomas, Wendt, Lisa

“…Ebola virus and other orthoebolaviruses cause severe haemorrhagic fevers in humans, with very high case fatality rates. Their non-segmented single-stranded RNA…”
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Remdesivir inhibits the polymerases of the novel filoviruses Lloviu and Bombali virus by Bodmer, Bianca S., Zierke, Lukas, Wendt, Lisa, Greßler, Josephin, Groseth, Allison, Hoenen, Thomas

“…In recent years, a number of novel filoviruses (e.g. Lloviu virus (LLOV) and Bombali virus (BOMV)) have been discovered. While antibody-based therapeutics have…”
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A Measles Virus-Based Vaccine Candidate Mediates Protection against Zika Virus in an Allogeneic Mouse Pregnancy Model by Nürnberger, Cindy, Bodmer, Bianca S, Fiedler, Anna H, Gabriel, Gülsah, Mühlebach, Michael D

“…The impact of the Zika virus (ZIKV) epidemic highlights the need for vaccines that reduce or prevent infection and reliably prevent teratogenic complications…”
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Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model by Bodmer, Bianca S., Fiedler, Anna H., Hanauer, Jan R.H., Prüfer, Steffen, Mühlebach, Michael D.

“…Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One…”
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Ebola Virus Infection of Flt3-Dependent, Conventional Dendritic Cells and Antigen Cross-presentation Leads to High Levels of T-Cell Activation by Niemetz, Linda, Bodmer, Bianca S, Olal, Catherine, Escudero-Pérez, Beatriz, Hoehn, Katharina, Bencsik, András, Vickers, Molly A, Rodríguez, Estefanía, Oestereich, Lisa, Hoenen, Thomas, Muñoz-Fontela, César

“…Previous studies have described that Ebola virus (EBOV) infection of human monocyte-derived dendritic cells (moDCs) inhibits dendritic cell (DC) maturation,…”
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N 6 -methyladenosine is required for efficient RNA synthesis of Ebola virus and other haemorrhagic fever viruses by Wendt, Lisa, Pickin, Matthew J, Bodmer, Bianca S, Reiche, Sven, Fénéant, Lucie, Hölper, Julia E, Fuchs, Walter, Groseth, Allison, Hoenen, Thomas

“…N -methyladenosine (m A) is one of the most abundant modifications of cellular RNA, where it serves various functions. m A methylation of many viral RNA…”
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Antigen-specific oncolytic MV-based tumor vaccines through presentation of selected tumor-associated antigens on infected cells or virus-like particles by Hutzler, Stefan, Erbar, Stephanie, Jabulowsky, Robert A., Hanauer, Jan R. H., Schnotz, Jürgen H., Beissert, Tim, Bodmer, Bianca S., Eberle, Regina, Boller, Klaus, Klamp, Thorsten, Sahin, Ugur, Mühlebach, Michael D.

“…Recombinant vaccine strain-derived measles virus (MV) is clinically tested both as vaccine platform to protect against other pathogens and as oncolytic virus…”
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Lentiviral Protein Transfer Vectors Are an Efficient Vaccine Platform and Induce a Strong Antigen-Specific Cytotoxic T Cell Response by Uhlig, Katharina M, Schülke, Stefan, Scheuplein, Vivian A M, Malczyk, Anna H, Reusch, Johannes, Kugelmann, Stefanie, Muth, Anke, Koch, Vivian, Hutzler, Stefan, Bodmer, Bianca S, Schambach, Axel, Buchholz, Christian J, Waibler, Zoe, Scheurer, Stephan, Mühlebach, Michael D

“…To induce and trigger innate and adaptive immune responses, antigen-presenting cells (APCs) take up and process antigens. Retroviral particles are capable of…”
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