Search Results - "Bodkin, N L"

Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population by DE KONING, E. J. P, BODKIN, N. L, HANSEN, B. C, CLARK, A

“…Diabetes mellitus in Macaca mulatta rhesus monkeys is preceded by phases of obesity and hyperinsulinaemia and is similar to Type 2 (non-insulin-dependent)…”
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Long-Term Calorie Restriction Reduces Energy Expenditure in Aging Monkeys by DeLany, James P., Hansen, Barbara C., Bodkin, Noni L., Hannah, Judith, Bray, George A.

“…Calorie restriction to produce stable long-term adult body weight for approximately 10 years prevents obesity and diabetes in middle-aged rhesus monkeys. To…”
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Primary prevention of diabetes mellitus by prevention of obesity in monkeys by Hansen, B. C., Bodkin, N. L.

“…Primary prevention of diabetes mellitus by prevention of obesity in monkeys. B C Hansen and N L Bodkin Obesity and Diabetes Research Center, University of…”
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The effects of K-111, a new insulin-sensitizer, on metabolic syndrome in obese prediabetic rhesus monkeys by Bodkin, N L, Pill, J, Meyer, K, Hansen, B C

“…K-111, formerly BM 17.0744, (2,2-dichloro-12-(4-chlorophenyl)-dodecanoic acid) is a new insulin-sensitizer with peroxisome proliferator-activated receptor…”
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Calorie restriction in nonhuman primates : Mechanisms of reduced morbidity and mortality by HANSEN, B. C, BODKIN, N. L, ORTMEYER, H. K

“…Long term chronic calorie restriction (CR) of adult nonhuman primates significantly reduces morbidity and increases median age of death. The present review is…”
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Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta) by Pendergrass, W.R., Lane, M.A., Bodkin, N.L., Hansen, B.C., Ingram, D.K., Roth, G.S., Yi, L., Bin, H., Wolf, N.S.

“…Caloric restriction (CR) is the most successful method of extending both median and maximal lifespans in rodents and other short‐lived species. It is not yet…”
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Heterogeneity of insulin responses: phases leading to Type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey by HANSEN, B. C, BODKIN, N. L

“…To determine the natural history of the development of Type 2 (non-insulin-dependent) diabetes mellitus, basal plasma insulin and glucose levels and responses…”
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Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys by HOTTA, Kikuko, FUNAHASHI, Tohru, BODKIN, Noni L, ORTMEYER, Heidi K, ARITA, Yukio, HANSEN, Barbara C, MATSUZAWA, Yuji

“…Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2…”
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Long-term dietary restriction in older-aged rhesus monkeys: effects on insulin resistance by Bodkin, N L, Ortmeyer, H K, Hansen, B C

“…Long-term dietary restriction to maintain constant body weight in adult rhesus monkeys prevents the development of impaired glucose tolerance, hyperglycemia,…”
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Central obesity in rhesus monkeys: association with hyperinsulinemia, insulin resistance and hypertriglyceridemia? by Bodkin, N L, Hannah, J S, Ortmeyer, H K, Hansen, B C

“…Total body fat and anthropometric assessments of fat distribution were examined in 23 lean and obese rhesus monkeys (Macaca mulatta). In addition, the…”
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Insulin regulates liver glycogen synthase and glycogen phosphorylase activity reciprocally in rhesus monkeys by Ortmeyer, H K, Bodkin, N L, Hansen, B C

“…In skeletal muscle of both humans and monkeys, the effects of in vivo insulin during a euglycemic hyperinsulinemic clamp on the enzymes and substrates of…”
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A Selective Peroxisome Proliferator-Activated Receptor δ Agonist Promotes Reverse Cholesterol Transport by Oliver, William R., Shenk, Jennifer L., Snaith, Mike R., Russell, Caroline S., Plunket, Kelli D., Bodkin, Noni L., Lewis, Michael C., Winegar, Deborah A., Sznaidman, Marcos L., Lambert, Millard H., Xu, H. Eric, Sternbach, Daniel D., Kliewer, Steven A., Hansen, Barbara C., Willson, Timothy M.

“…The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic…”
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Beta-cell hyperresponsiveness: earliest event in development of diabetes in monkeys by Hansen, B C, Bodkin, N L

“…Diabetes develops spontaneously in some, but not all, obese middle-aged monkeys. Longitudinal study of spontaneously obese rhesus monkeys has now shown the…”
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Mortality and Morbidity in Laboratory-maintained Rhesus Monkeys and Effects of Long-term Dietary Restriction by Bodkin, Noni L., Alexander, Theresa M., Ortmeyer, Heidi K., Johnson, Elizabeth, Hansen, Barbara C.

“…Mortality and morbidity were examined in 117 laboratory-maintained rhesus monkeys studied over approximately 25 years (8 dietary-restricted [DR] and 109 ad…”
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Relationship of skeletal muscle glucose 6-phosphate to glucose disposal rate and glycogen synthase activity in insulin-resistant and non-insulin-dependent diabetic rhesus monkeys by ORTMEYER, H. K, BODKIN, N. L, HANSEN, B. C

“…Reduced insulin action on skeletal muscle glycogen synthase activity and reduced whole-body insulin-mediated glucose disposal rates in insulin-resistant…”
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Hepatic glucose production and insulin sensitivity preceding diabetes in monkeys by Bodkin, N.L, Metzger, B.L, Hansen, B.C

“…The purpose of this study was to identify the relationship between basal hepatic glucose production (HGP) and peripheral insulin sensitivity as assessed by the…”
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Relationships of PPARγ and PPARγ2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys by HOTTA, K, GUSTAFSON, T. A, YOSHIOKA, S, ORTMEYER, H. K, BODKIN, N. L, HANSEN, B. C

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Insulin-mediated glycogen synthase activity in muscle of spontaneously insulin-resistant and diabetic rhesus monkeys by Ortmeyer, H.K, Bodkin, N.L, Hansen, B.C

“…Altered insulin action on glycogen synthase activity has been well recognized in non-insulin-dependent diabetes, and some prior evidence has suggested this…”
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Hyperleptinemia: relationship to adiposity and insulin resistance in the spontaneously obese rhesus monkey by Bodkin, N L, Nicolson, M, Ortmeyer, H K, Hansen, B C

“…Plasma leptin levels in normal-weight and spontaneously obese male rhesus monkeys, and the relationships of circulating leptin to beta-cell basal secretion,…”
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Adipose tissue glycogen synthase activation by in vivo insulin in spontaneously insulin-resistant and type 2 (non-insulin-dependent) diabetic rhesus monkeys by ORTMEYER, H. K, BODKIN, N. L, HANSEN, B. C

“…In skeletal muscle, a defect in the covalent activation of glycogen synthase by insulin has been identified in insulin resistance and in Type 2…”
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