Search Results - "Bode, Konrad A."

Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats by Guivala, Salmina J, Bode, Konrad A, Okun, Jürgen G, Kartal, Ece, Schwedhelm, Edzard, Pohl, Luca V, Werner, Sarah, Erbs, Sandra, Thiele, Holger, Büttner, Petra

“…Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes…”
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Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway by Hildebrand, Dagmar, Bode, Konrad A., Rieß, David, Cerny, Daniela, Waldhuber, Anna, Römmler, Franziska, Strack, Julia, Korten, Simone, Orth, Joachim H.C., Miethke, Thomas, Heeg, Klaus, Kubatzky, Katharina F.

“…Bacterial components are recognized by the immune system through activation of the inflammasome, eventually causing processing of the proinflammatory cytokine…”
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Gα q modulates the energy metabolism of osteoclasts by Chakraborty, Sushmita, Handrick, Bianca, Yu, Dayoung, Bode, Konrad A, Hafner, Anna, Schenz, Judith, Schaack, Dominik, Uhle, Florian, Tachibana, Taro, Kamitani, Shigeki, Vogl, Thomas, Kubatzky, Katharina F

“…The bacterial protein toxin toxin (PMT) mediates RANKL-independent osteoclast differentiation. Although these osteoclasts are smaller, their resorptive…”
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Hsa-miR-99b/let-7e/miR-125a Cluster Regulates Pathogen Recognition Receptor-Stimulated Suppressive Antigen-Presenting Cells by Hildebrand, Dagmar, Eberle, Mariel-Esther, Wölfle, Sabine Marie, Egler, Franziska, Sahin, Delal, Sähr, Aline, Bode, Konrad A, Heeg, Klaus

“…Antigen-presenting cells (APCs) regulate the balance of our immune response toward microbes. Whereas immunogenic APCs boost inflammation and activate…”
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Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment by Bode, Konrad A, Schroder, Kate, Hume, David A, Ravasi, Timothy, Heeg, Klaus, Sweet, Matthew J, Dalpke, Alexander H

“…Post-translational modifications of histone proteins are major mechanisms that modify chromatin structure and regulate gene expression in eukaryotes…”
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IL-1β As Mediator of Resolution That Reprograms Human Peripheral Monocytes toward a Suppressive Phenotype by Giesbrecht, Katharina, Eberle, Mariel-Esther, Wölfle, Sabine J, Sahin, Delal, Sähr, Aline, Oberhardt, Valerie, Menne, Zach, Bode, Konrad A, Heeg, Klaus, Hildebrand, Dagmar

“…During infection pathogen-associated molecular patterns activate immune cells to initiate a cascade of reactions leading to inflammation and the activation of…”
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Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells by Schmidt, Lotte M, Belvisi, Maria G, Bode, Konrad A, Bauer, Judith, Schmidt, Claudia, Suchy, Maria-Theresia, Tsikas, Dimitrios, Scheuerer, Jutta, Lasitschka, Felix, Gröne, Herman-Josef, Dalpke, Alexander H

“…Airway epithelial cells regulate immune reactivity of local dendritic cells (DCs), thus contributing to microenvironment homeostasis. In this study, we set out…”
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Kinetic of RelA Activation Controls Magnitude of TLR-Mediated IL-12p40 Induction by Bode, Konrad A, Schmitz, Frank, Vargas, Leonardo, Heeg, Klaus, Dalpke, Alexander H

“…IL-12 is a crucial cytokine for dendritic cell-mediated induction of Th 1 cell differentiation. TLR ligands induce IL-12 to differing extents. Stimulation of…”
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Integration of matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry in blood culture diagnostics: a fast and effective approach by KLEIN, Sabrina, ZIMMERMANN, Stefan, KÖHLER, Christine, MISCHNIK, Alexander, ALLE, Werner, BODE, Konrad A

“…Sepsis is a major cause of mortality in hospitalized patients worldwide, with lethality rates ranging from 30 to 70 %. Sepsis is caused by a variety of…”
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Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide by Eigenbrod, Tatjana, Bode, Konrad A, Dalpke, Alexander H

“…The significance of bacterial RNA recognition for initiating innate immune responses against invading pathogens has only recently started to be elucidated…”
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Evaluation of antibiotic resistance to orally administrable antibiotics in staphylococcal bone and joint infections in one of the largest university hospitals in Germany: is there a role for fusidic acid? by Klein, Sabrina, Nurjadi, Dennis, Eigenbrod, Tatjana, Bode, Konrad A

“…Highlights • Resistance to commonly used oral antibiotics to treat staphylococcal bone and joint infections (BJIs) is increasing. • 75% of MRSA and ca. 50% of…”
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Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism by Stammler, Dominik, Eigenbrod, Tatjana, Menz, Sarah, Frick, Julia S, Sweet, Matthew J, Shakespear, Melanie R, Jantsch, Jonathan, Siegert, Isabel, Wölfle, Sabine, Langer, Julian D, Oehme, Ina, Schaefer, Liliana, Fischer, Andre, Knievel, Judith, Heeg, Klaus, Dalpke, Alexander H, Bode, Konrad A

“…Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the…”
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Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate by Bode, Konrad A, Donner, Markus G, Leier, Inka, Keppler, Dietrich

“…Hyperbilirubinemia is a frequent side effect induced by long-term therapy with the antibiotic fusidate. The aim of this study was to elucidate the molecular…”
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Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3 by Ehlting, Christian, Ronkina, Natalia, Böhmer, Oliver, Albrecht, Ute, Bode, Konrad A, Lang, Karl S, Kotlyarov, Alexey, Radzioch, Danuta, Gaestel, Matthias, Häussinger, Dieter, Bode, Johannes G

“…In LPS-treated macrophages, activation of STAT3 is considered to be crucial for terminating the production of inflammatory cytokines. By analyzing the role of…”
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HDAC inhibitors block innate immunity by Bode, Konrad A., Dalpke, Alexander H.

“…In this issue of Blood, Roger and colleagues present data on the magnitude of influence that broad-spectrum HDAC inhibitors exert on TLR-driven immune…”
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IRAK4 turns IL‐10+ phospho‐FOXO+ monocytes into pro‐inflammatory cells by suppression of protein kinase B by Over, Benjamin, Ziegler, Saskia, Foermer, Sandra, Weber, Alexander N.R., Bode, Konrad A., Heeg, Klaus, Bekeredjian‐Ding, Isabelle

“…IRAK4, a serine/threonine kinase is a central adaptor protein in TLR signaling. To better understand the clinical significance of IRAK4 deficiency we examined…”
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Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n‐butyrate by Lasitschka, Felix, Giese, Thomas, Paparella, Marco, Kurzhals, Stefan R., Wabnitz, Guido, Jacob, Katrin, Gras, Judith, Bode, Konrad A., Heninger, Anne‐Kristin, Sziskzai, Timea, Samstag, Yvonne, Leszinski, Cornelia, Jocher, Bettina, Al‐Saeedi, Mohammed, Meuer, Stefan C., Schröder‐Braunstein, Jutta

“…Introduction Hyporesponsiveness of human lamina propria immune cells to microbial and nutritional antigens represents one important feature of intestinal…”
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Differential Effects of CpG DNA on IFN-beta Induction and STAT1 Activation in Murine Macrophages versus Dendritic Cells: Alternatively Activated STAT1 Negatively Regulates TLR Signaling in Macrophages by Schroder, Kate, Spille, Martina, Pilz, Andreas, Lattin, Jane, Bode, Konrad A, Irvine, Katharine M, Burrows, Allan D, Ravasi, Timothy, Weighardt, Heike, Stacey, Katryn J, Decker, Thomas, Hume, David A, Dalpke, Alexander H, Sweet, Matthew J

“…Classical STAT1 activation in response to TLR agonists occurs by phosphorylation of the Y701 and S727 residues through autocrine type I IFN signaling and p38…”
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Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3 by Ehlting, Christian, Ronkina, Natalia, Böhmer, Oliver, Albrecht, Ute, Bode, Konrad A., Lang, Karl S., Kotlyarov, Alexey, Radzioch, Danuta, Gaestel, Matthias, Häussinger, Dieter, Bode, Johannes G.

“…In LPS-treated macrophages, activation of STAT3 is considered to be crucial for terminating the production of inflammatory cytokines. By analyzing the role of…”
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Es gibt sie doch, die Trichomoniasis in Deutschland: Der molekularbiologische Labornachweis ist erfolgreich by Bode, Konrad A., Frischmann, Ingelore, Hof, Herbert

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