Search Results - "Bode, AM"

The Two Faces of Capsaicin by BODE, Ann M, ZIGANG DONG

“…Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the principal pungent component in hot peppers, including red chili peppers, jalapeños, and habaneros…”
Get full text

Post-translational modification of p53 in tumorigenesis by Dong, Zigang, Bode, Ann M

“…Interest in the tumour suppressor p53 has generated much information regarding the complexity of its function and regulation in carcinogenesis. However, gaps…”
Get full text

Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells by Yan, F, Shen, N, Pang, J X, Zhang, Y W, Rao, E Y, Bode, A M, Al-Kali, A, Zhang, D E, Litzow, M R, Li, B, Liu, S J

“…Obesity is becoming more prevalent worldwide and is a major risk factor for cancer development. Acute myeloid leukemia (AML), the most common acute leukemia in…”
Get full text

A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target by Yan, F, Shen, N, Pang, J X, Zhao, N, Zhang, Y W, Bode, A M, Al-Kali, A, Litzow, M R, Li, B, Liu, S J

“…Aberrant DNA methylation mediated by deregulation of DNA methyltransferases (DNMT) is a key hallmark of acute myeloid leukemia (AML), yet efforts to target…”
Get full text

Targeting PRPK and TOPK for skin cancer prevention and therapy by Roh, Eunmiri, Lee, Mee-Hyun, Zykova, Tatyana A., Zhu, Feng, Nadas, Janos, Kim, Hong-Gyum, Bae, Ki Beom, Li, Yan, Cho, Yong Yeon, Curiel-Lewandrowski, Clara, Einspahr, Janine, Dickinson, Sally E., Bode, Ann M., Dong, Zigang

“…Solar ultraviolet (sUV) irradiation is a major environmental carcinogen that can cause inflammation and skin cancer. The costs and morbidity associated with…”
Get full text

Targeting signal transduction pathways by chemopreventive agents by Bode, A M, Dong, Z

“…Cancer is a dynamic process that involves many complex factors, which may explain why a "magic bullet" cure for cancer has not been found. Death rates are…”
Get more information

Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1 by Oi, N, Yuan, J, Malakhova, M, Luo, K, Li, Y, Ryu, J, Zhang, L, Bode, A M, Xu, Z, Li, Y, Lou, Z, Dong, Z

“…Resveratrol ( trans -3,5,4′-truhydroxystilbene) possesses a strong anticancer activity exhibited as the induction of apoptosis through p53 activation. However,…”
Get full text

Transient Receptor Potential Type Vanilloid 1 Suppresses Skin Carcinogenesis by BODE, Ann M, CHO, Yong-Yeon, DUO ZHENG, FENG ZHU, ERICSON, Marna E, MA, Wei-Ya, KE YAO, ZIGANG DONG

“…Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 is a…”
Get full text

The Intermediate Filament Protein Vimentin Is a New Target for Epigallocatechin Gallate by Ermakova, Svetlana, Choi, Bu Young, Choi, Hong Seok, Kang, Bong Seok, Bode, Ann M., Dong, Zigang

“…Epigallocatechin gallate (EGCG) is the major active polyphenol in green tea. Protein interaction with EGCG is a critical step in the effects of EGCG on the…”
Get full text

The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects by Bode, Ann M., Dong, Zigang

“…Arsenic is a well-documented carcinogen that also appears to be a valuable therapeutic tool in cancer treatment. This creates a paradox for which no unified…”
Get full text

Abstract P1-08-03: Identification and characterization of a novel endoxifen substrate, PKCβ1, and its interaction with the estrogen receptor by Guo, C, Kuffel, MJ, Kudgus, RA, Huang, Z, Bode, AM, Cheng, J, Suman, VJ, Reid, JM, Bruinsma, ES, Subramaniam, M, Ames, MM, Hawse, JR, Goetz, MP

“…Abstract Background: The primary mechanism by which tamoxifen (Tam) and its metabolites exert their biologic effects is through estrogen receptor (ER) binding…”
Get full text

Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase by SHE, Qing-Bai, BODE, Ann M, MA, Wei-Ya, CHEN, Nan-Yue, ZIGANG DONG

“…Resveratrol, a phytoalexin found in grapes, berries, and peanuts, is one of the most promising agents for cancer prevention. Our previous study showed that the…”
Get full text

P3-11-07: Mammary Gland Biopsy To Examine Surrogate Endpoint Biomarkers of Preventive Agent Efficacy by Heckman-Stoddard, B, Lubet, RA, Bode, AM, Grubbs, CJ

“…Abstract Phase II breast cancer prevention trials examine agent activity by sampling and imaging the breast through core needle biopsy, fine needle aspiration,…”
Get full text

P3-10-01: Alternative Dosing Regimens with the EGFr Inhibitors (Gefitinib and Lapatinib) in Mammary Cancer Models: Prevention and Therapeutic Efficacy by Lubet, RA, Bode, AM, Szabo, E, Grubbs, CJ

“…Abstract The EGFR inhibitors are effective in treatment of lung and pancreatic cancers (erlotinib, gefitinib) and Neu overexpressing breast cancer (lapatinib)…”
Get full text

Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways by ZHIWEI HE, MA, Wei-Ya, HASHIMOTO, Takashi, BODE, Ann M, YANG, Chung S, ZIGANG DONG

“…Caffeine is a key component of many popular drinks, especially tea and coffee. Previous reports have shown that caffeine may contribute to the chemopreventive…”
Get full text

P5-06-11: Quercetin-3-Methyl Ether Inhibits Lapatinib-Sensitive and Lapatinib-Resistant Breast Cancer Cell Growth by Inducing G2/M Arrest and Apoptosis by Bode, AM, Li, J, Zhu, F, Normanno, NE, Ericson, ME, Lubet, RA

“…Abstract Background: Lapatinib, an oral, small-molecule, reversible inhibitor of both EGFR and HER2, is highly active in HER2 positive breast cancer as a…”
Get full text

Abstract P5-09-08: A comparison of the non-genomic effects of endoxifen and tamoxifen in aromatase inhibitor resistant breast cancer: Differential effects on the estrogen receptor co-regulator SRC3 (AIB1) and identification of PKC and PI3K as endoxifen substrates by Goetz, MP, Kuffel, M, Reinicke, KE, Huang, Z, Bode, AM, Cheng, J, Hoskin, T, Suman, VJ, Artega, C, Reid, J, Hawse, J, Ames, M

“…Abstract Background: Endoxifen (Endx) is being developed as a drug for patients with estrogen receptor (ER)+ breast cancer (BC). We previously demonstrated…”
Get full text

Abstract PD03-07: Evaluation of the Anti-Diabetic Drug Metformin in the Methylnitrosourea (MNU)-Induced Model of ER+ Mammary Cancer and the MMTV-Neu/p53KO Model of ER-Mammary Cancer by Grubbs, CJ, Bode, AM, Steele, VE, Lubet, RA

“…Abstract Metformin, an anti-diabetic drug, activates AMP-activated protein kinase (AMPK), and has generated a great deal of interest as a potential preventive…”
Get full text

Deficiency of c-Jun-NH2-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate by SHE, Qing-Bai, CHEN, Nanyue, BODE, Ann M, FLAVELL, Richard A, ZIGANG DONG

Get full text

Suppression of skin tumorigenesis in c-Jun NH2-terminal kinase-2-deficient mice by NANYUE CHEN, NOMURA, Masaaki, SHE, Qing-Bai, MA, Wei-Ya, BODE, Ann M, LINAN WANG, FLAVELL, Richard A, ZIGANG DONG

Get full text