Search Results - "Boddy, Michael"

Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability by Nie, Minghua, Boddy, Michael N

“…Covalent attachment of ubiquitin (Ub) or SUMO to DNA repair proteins plays critical roles in maintaining genome stability. These structurally related…”
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Recruitment, loading, and activation of the Smc5–Smc6 SUMO ligase by Oravcová, Martina, Boddy, Michael N.

“…Duplication of the genome poses one of the most significant threats to genetic integrity, cellular fitness, and organismal health. Therefore, numerous…”
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SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion by Nie, Minghua, Moser, Bettina A, Nakamura, Toru M, Boddy, Michael N

“…The posttranslational modifiers SUMO and ubiquitin critically regulate the DNA damage response (DDR). Important crosstalk between these modifiers at DNA…”
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FAM111A induces nuclear dysfunction in disease and viral restriction by Nie, Minghua, Oravcová, Martina, Jami-Alahmadi, Yasaman, Wohlschlegel, James A, Lazzerini-Denchi, Eros, Boddy, Michael N

“…Mutations in the nuclear trypsin-like serine protease FAM111A cause Kenny–Caffey syndrome (KCS2) with hypoparathyroidism and skeletal dysplasia or perinatally…”
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Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress by Oravcová, Martina, Gadaleta, Mariana C., Nie, Minghua, Reubens, Michael C., Limbo, Oliver, Russell, Paul, Boddy, Michael N.

“…As genetic instability drives disease or loss of cell fitness, cellular safeguards have evolved to protect the genome, especially during sensitive cell cycle…”
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SUMO-targeted ubiquitin ligases in genome stability by Prudden, John, Pebernard, Stephanie, Raffa, Grazia, Slavin, Daniela A, Perry, J Jefferson P, Tainer, John A, McGowan, Clare H, Boddy, Michael N

“…We identify the SUMO‐Targeted Ubiquitin Ligase (STUbL) family of proteins and propose that STUbLs selectively ubiquitinate sumoylated proteins and proteins…”
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The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers by Oravcová, Martina, Nie, Minghua, Zilio, Nicola, Maeda, Shintaro, Jami-Alahmadi, Yasaman, Lazzerini-Denchi, Eros, Wohlschlegel, James A, Ulrich, Helle D, Otomo, Takanori, Boddy, Michael N

“…The human SMC5/6 complex is a conserved guardian of genome stability and an emerging component of antiviral responses. These disparate functions likely require…”
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SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability by Heideker, Johanna, Prudden, John, Perry, J Jefferson P, Tainer, John A, Boddy, Michael N

“…Through as yet undefined proteins and pathways, the SUMO-targeted ubiquitin ligase (STUbL) suppresses genomic instability by ubiquitinating SUMO conjugated…”
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Dual Recruitment of Cdc48 (p97)-Ufd1-Npl4 Ubiquitin-selective Segregase by Small Ubiquitin-like Modifier Protein (SUMO) and Ubiquitin in SUMO-targeted Ubiquitin Ligase-mediated Genome Stability Functions by Nie, Minghua, Aslanian, Aaron, Prudden, John, Heideker, Johanna, Vashisht, Ajay A., Wohlschlegel, James A., Yates, John R., Boddy, Michael N.

“…Protein modification by SUMO and ubiquitin critically impacts genome stability via effectors that “read” their signals using SUMO interaction motifs or…”
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Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1 by Nie, Minghua, Arner, Emily, Prudden, John, Schaffer, Lana, Head, Steven, Boddy, Michael N

“…Posttranslational modifications (PTMs) provide dynamic regulation of the cellular proteome, which is critical for both normal cell growth and for orchestrating…”
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The Dynamics and Mechanism of SUMO Chain Deconjugation by SUMO-specific Proteases by Békés, Miklós, Prudden, John, Srikumar, Tharan, Raught, Brian, Boddy, Michael N., Salvesen, Guy S.

“…SUMOylation of proteins is a cyclic process that requires both conjugation and deconjugation of SUMO moieties. Besides modification by a single SUMO, SUMO…”
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A Novel Histone Deacetylase Complex in the Control of Transcription and Genome Stability by Zilio, Nicola, Codlin, Sandra, Vashisht, Ajay A., Bitton, Danny A., Head, Steven R., Wohlschlegel, James A., Bähler, Jürg, Boddy, Michael N.

“…The acetylation state of histones, controlled by histone acetyltransferases (HATs) and deacetylases (HDACs), profoundly affects DNA transcription and repair by…”
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Improved Tandem Affinity Purification Tag and Methods for Isolation of Proteins and Protein Complexes from Schizosaccharomyces pombe by Zilio, Nicola, Boddy, Michael N

“…The tandem affinity purification (TAP) method uses an epitope that contains two different affinity purification tags separated by a site-specific protease site…”
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Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively by Pebernard, Stephanie, Schaffer, Lana, Campbell, Daniel, Head, Steven R, Boddy, Michael N

“…The Smc5/6 holocomplex executes key functions in genome maintenance that include ensuring the faithful segregation of chromosomes at mitosis and facilitating…”
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High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification by Nie, Minghua, Vashisht, Ajay A., Wohlschlegel, James A., Boddy, Michael N.

“…Covalent attachment of the small ubiquitin-like modifier (SUMO) to key targets in the proteome critically regulates the evolutionarily conserved processes of…”
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Large-Scale Purification of Small Ubiquitin-Like Modifier (SUMO)-Modified Proteins from Schizosaccharomyces pombe by Nie, Minghua, Boddy, Michael N

“…Covalent protein modification by sumoylation (i.e., addition of small ubiquitin-like modifiers [SUMOs]) regulates a broad spectrum of critical functions in…”
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The RecQ4 Orthologue Hrq1 Is Critical for DNA Interstrand Cross-Link Repair and Genome Stability in Fission Yeast by Groocock, Lynda M., Prudden, John, Perry, J. Jefferson P., Boddy, Michael N.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response by Groocock, Lynda M, Nie, Minghua, Prudden, John, Moiani, Davide, Wang, Tao, Cheltsov, Anton, Rambo, Robert P, Arvai, Andrew S, Hitomi, Chiharu, Tainer, John A, Luger, Karolin, Perry, J Jefferson P, Lazzerini-Denchi, Eros, Boddy, Michael N

“…The post‐translational modification of DNA repair and checkpoint proteins by ubiquitin and small ubiquitin‐like modifier (SUMO) critically orchestrates the DNA…”
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Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress by Kai, Mihoko, Boddy, Michael N, Russell, Paul, Wang, Teresa S-F

“…The replication checkpoint kinase Cds1 preserves genome integrity by stabilizing stalled replication forks. Cds1 targets substrates through its FHA domain. The…”
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The Nse5-Nse6 Dimer Mediates DNA Repair Roles of the Smc5-Smc6 Complex by Pebernard, Stephanie, Wohlschlegel, James, McDonald, W. Hayes, Yates, John R., Boddy, Michael N.

“…ERRATUM ( vol. 26 , p. 3336 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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