Search Results - "Boddul, Sanjaykumar"

CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies by Jiang, Long, Ingelshed, Katrine, Shen, Yunbing, Boddul, Sanjaykumar V, Iyer, Vaishnavi Srinivasan, Kasza, Zsolt, Sedimbi, Saikiran, Lane, David P, Wermeling, Fredrik

“…Inactivating mutations are the most abundant genetic alterations found in cancer. Here we show that CRISPR/Cas9-induced double-stranded DNA breaks enrich for…”
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IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints by Panda, Sudeepta Kumar, Wigerblad, Gustaf, Jiang, Long, Jiménez-Andrade, Yanek, Iyer, Vaishnavi Srinivasan, Shen, Yunbing, Boddul, Sanjaykumar V., Guerreiro-Cacais, André Ortlieb, Raposo, Bruno, Kasza, Zsolt, Wermeling, Fredrik

“…Neutrophils are the most abundant immune cells found in actively inflamed joints of patients with rheumatoid arthritis (RA), and most animal models for RA…”
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A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis by Pahlevan Kakhki, Majid, Giordano, Antonino, Starvaggi Cucuzza, Chiara, Venkata S. Badam, Tejaswi, Samudyata, Samudyata, Lemée, Marianne Victoria, Stridh, Pernilla, Gkogka, Asimenia, Shchetynsky, Klementy, Harroud, Adil, Gyllenberg, Alexandra, Liu, Yun, Boddul, Sanjaykumar, James, Tojo, Sorosina, Melissa, Filippi, Massimo, Esposito, Federica, Wermeling, Fredrik, Gustafsson, Mika, Casaccia, Patrizia, Hillert, Jan, Olsson, Tomas, Kockum, Ingrid, Sellgren, Carl M., Golzio, Christelle, Kular, Lara, Jagodic, Maja

“…Multiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating…”
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Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3 by Steinmetz-Späh, Julia, Liu, Jianyang, Singh, Rajkumar, Ekoff, Maria, Boddul, Sanjaykumar, Tang, Xiao, Bergqvist, Filip, Idborg, Helena, Heitel, Pascal, Rönnberg, Elin, Merk, Daniel, Wermeling, Fredrik, Haeggström, Jesper Z., Nilsson, Gunnar, Steinhilber, Dieter, Larsson, Karin, Korotkova, Marina, Jakobsson, Per-Johan

“…Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased production of proinflammatory PGE2 and can lead to shunting of PGH2 into the…”
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Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2 by Iyer, Vaishnavi Srinivasan, Boddul, Sanjaykumar V., Johnsson, Anna-Karin, Raposo, Bruno, Sharma, Ravi K., Shen, Yunbing, Kasza, Zsolt, Lim, Kah Wai, Chemin, Karine, Nilsson, Gunnar, Malmström, Vivianne, Phan, Anh Tuân, Wermeling, Fredrik

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Designing custom CRISPR libraries for hypothesis-driven drug target discovery by Iyer, Vaishnavi Srinivasan, Jiang, Long, Shen, Yunbing, Boddul, Sanjaykumar V., Panda, Sudeepta Kumar, Kasza, Zsolt, Schmierer, Bernhard, Wermeling, Fredrik

“…Over the last decade Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has been developed into a potent molecular biology tool used to rapidly…”
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An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma by Record, Julien, Sendel, Anton, Kritikou, Joanna S, Kuznetsov, Nikolai V, Brauner, Hanna, He, Minghui, Nagy, Noemi, Oliveira, Mariana M S, Griseti, Elena, Haase, Christoph B, Dahlström, Jenny, Boddul, Sanjaykumar, Wermeling, Fredrik, Thrasher, Adrian J, Liu, Chaohong, Andersson, John, Claesson, Hans-Erik, Winqvist, Ola, Burns, Siobhan O, Björkholm, Magnus, Westerberg, Lisa S

“…Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together they regulate transcription of actin cytoskeleton genes. MKL1 is…”
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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…[Display omitted] •CRISPR generates genetic heterogeneity at the targeted site.•Genetic heterogeneity complicates identification of the role of a targeted…”
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In vitro and ex vitro functional characterization of human HLA-DRB1∗04 restricted T cell receptors by Boddul, Sanjaykumar V, Sharma, Ravi Kumar, Dubnovitsky, Anatoly, Raposo, Bruno, Gerstner, Christina, Shen, Yunbing, Iyer, Vaishnavi Srinivasan, Kasza, Zsolt, Kwok, William W, Winkler, Aaron R, Klareskog, Lars, Malmström, Vivianne, Bettini, Maria, Wermeling, Fredrik

“…Recent advances in single-cell sequencing technologies enable the generation of large-scale data sets of paired TCR sequences from patients with autoimmune…”
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In vitro and ex vivo functional characterization of human HLA-DRB1∗04 restricted T cell receptors by Boddul, Sanjaykumar V., Sharma, Ravi Kumar, Dubnovitsky, Anatoly, Raposo, Bruno, Gerstner, Christina, Shen, Yunbing, Iyer, Vaishnavi Srinivasan, Kasza, Zsolt, Kwok, William W., Winkler, Aaron R., Klareskog, Lars, Malmström, Vivianne, Bettini, Maria, Wermeling, Fredrik

“…Recent advances in single-cell sequencing technologies enable the generation of large-scale data sets of paired TCR sequences from patients with autoimmune…”
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In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution by Kumar, Suresh, Koenig, Johannes, Schneider, Andreas, Wermeling, Fredrik, Boddul, Sanjaykumar, Theobald, Sebastian J., Vollmer, Miriam, Kloos, Doreen, Lachmann, Nico, Klawonn, Frank, Lienenklaus, Stefan, Talbot, Steven R., Bleich, André, Wenzel, Nadine, von Kaisenberg, Constantin, Keck, James, Stripecke, Renata

“…Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the human immune system (HIS-mice) are invigorating preclinical…”
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Biosynthesis of prostaglandin 15dPGJ 2 -glutathione and 15dPGJ 2 -cysteine conjugates in macrophages and mast cells via MGST3 by Steinmetz-Späh, Julia, Liu, Jianyang, Singh, Rajkumar, Ekoff, Maria, Boddul, Sanjaykumar, Tang, Xiao, Bergqvist, Filip, Idborg, Helena, Heitel, Pascal, Rönnberg, Elin, Merk, Daniel, Wermeling, Fredrik, Haeggström, Jesper Z, Nilsson, Gunnar, Steinhilber, Dieter, Larsson, Karin, Korotkova, Marina, Jakobsson, Per-Johan

“…Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased production of proinflammatory PGE and can lead to shunting of PGH into the…”
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In vitro and ex vivo functional characterization of human HLA-DRB104 restricted T cell receptors by Boddul, SV, Sharma, RK, Dubnovitsky, A, Raposo, B, Gerstner, C, Shen, Y, Iyer, VS, Kasza, Z, Kwok, WW, Winkler, AR

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