Search Results - "Boddington, Christopher"

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states by Adamson, Antony, Boddington, Christopher, Downton, Polly, Rowe, William, Bagnall, James, Lam, Connie, Maya-Mendoza, Apolinar, Schmidt, Lorraine, Harper, Claire V., Spiller, David G., Rand, David A., Jackson, Dean A., White, Michael R. H., Paszek, Pawel

“…Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability…”
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Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells by Brignall, Ruth, Cauchy, Pierre, Bevington, Sarah L, Gorman, Bethany, Pisco, Angela O, Bagnall, James, Boddington, Christopher, Rowe, William, England, Hazel, Rich, Kevin, Schmidt, Lorraine, Dyer, Nigel P, Travis, Mark A, Ott, Sascha, Jackson, Dean A, Cockerill, Peter N, Paszek, Pawel

“…TCR signaling pathways cooperate to activate the inducible transcription factors NF-κB, NFAT, and AP-1. In this study, using the calcium ionophore ionomycin…”
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Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation by Bagnall, James, Boddington, Christopher, England, Hazel, Brignall, Ruth, Downton, Polly, Alsoufi, Zainab, Boyd, James, Rowe, William, Bennett, Alexander, Walker, Catherine, Adamson, Antony, Patel, Nisha M X, O'Cualain, Ronan, Schmidt, Lorraine, Spiller, David G, Jackson, Dean A, Müller, Werner, Muldoon, Mark, White, Michael R H, Paszek, Pawel

“…Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In macrophage…”
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An Interdisciplinary Analysis of Inflammatory Signalling Dynamics in Single Cells by Boddington, Christopher

“…Immune cells must accurately interpret environmental signals to make robust cell fate decisions and control inflammatory signalling. Many signals (e.g. Tumor…”
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Signal transduction controls heterogeneous NF-[kappa]B dynamics and target gene expression through cytokine-specific refractory states by Adamson, Antony, Boddington, Christopher, Downton, Polly, Rowe, William, Bagnall, James, Lam, Connie, Maya-mendoza, Apolinar, Schmidt, Lorraine, Harper, Claire V, Spiller, David G, Rand, David A, Jackson, Dean A, White, Michael R H, Paszek, Pawel

“…Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability…”
Get full text