Search Results - "Boddeke, Erik W.G.M"

Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood by Schaafsma, Wandert, Basterra, Laura Bozal, Jacobs, Sabrina, Brouwer, Nieske, Meerlo, Peter, Schaafsma, Anne, Boddeke, Erik W.G.M., Eggen, Bart J.L.

“…Maternal inflammation during pregnancy can have detrimental effects on embryonic development that persist during adulthood. However, the underlying mechanisms…”
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Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease by Wes, Paul D., Holtman, Inge R., Boddeke, Erik W.G.M., Möller, Thomas, Eggen, Bart J.L.

“…Genome‐wide expression profiling technology has resulted in detailed transcriptome data for a wide range of tissues, conditions and diseases. In neuroscience,…”
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Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish by Oosterhof, Nynke, Holtman, Inge R., Kuil, Laura E., van der Linde, Herma C., Boddeke, Erik W.G.M., Eggen, Bart J.L., van Ham, Tjakko J.

“…Microglia are brain resident macrophages important for brain development, connectivity, homeostasis and disease. However, it is still largely unclear how…”
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Isolation of Microglia and Immune Infiltrates from Mouse and Primate Central Nervous System by Galatro, Thais F, Vainchtein, Ilia D, Brouwer, Nieske, Boddeke, Erik W G M, Eggen, Bart J L

“…Microglia are the innate immune cells of the central nervous system (CNS) and play an important role in the maintenance of tissue homeostasis, providing neural…”
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Involvement of chemokines in pain by Boddeke, Erik W.G.M

“…It is well established that neuroinflammation plays an important role in neurodegenerative diseases like Alzheimer's disease, stroke, traumatic brain- and…”
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Cultured rat microglia express functional β-chemokine receptors by Boddeke, Erik W.G.M, Meigel, Ingeborg, Frentzel, Stefan, Gourmala, Nouciba G, Harrison, Jeffrey K, Buttini, Manuel, Spleiss, O, Gebicke-Härter, Peter

“…We have investigated the functional expression of the β-chemokine receptors CCR1 to 5 in cultured rat microglia. RT-PCR analysis revealed constitutive…”
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Functional expression of the fractalkine (CX 3C) receptor and its regulation by lipopolysaccharide in rat microglia by Boddeke, Erik W.G.M, Meigel, Inge, Frentzel, Stefan, Biber, Knut, Renn, Li Q, Gebicke-Härter, Peter

“…Functional expression of CX 3CR1, a recently discovered receptor for the chemokine fractalkine, was investigated in cultured rat microglia. Reverse…”
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Transcriptional profiling of microglia; current state of the art and future perspectives by Gerrits, Emma, Heng, Yang, Boddeke, Erik W. G. M., Eggen, Bart J. L.

“…Microglia are the tissue macrophages of the central nervous system (CNS) and the first to respond to CNS dysfunction and disease. Gene expression profiling of…”
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The Kaleidoscope of Microglial Phenotypes by Dubbelaar, Marissa L, Kracht, Laura, Eggen, Bart J L, Boddeke, Erik W G M

“…Gene expression analyses of microglia, the tissue-resident macrophages of the central nervous system (CNS), led to the identification of homeostatic as well as…”
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A novel microglial subset plays a key role in myelinogenesis in developing brain by Wlodarczyk, Agnieszka, Holtman, Inge R, Krueger, Martin, Yogev, Nir, Bruttger, Julia, Khorooshi, Reza, Benmamar‐Badel, Anouk, de Boer‐Bergsma, Jelkje J, Martin, Nellie A, Karram, Khalad, Kramer, Isabella, Boddeke, Erik WGM, Waisman, Ari, Eggen, Bart JL, Owens, Trevor

“…Microglia are resident macrophages of the central nervous system that contribute to homeostasis and neuroinflammation. Although known to play an important role…”
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Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease by Gerrits, Emma, Brouwer, Nieske, Kooistra, Susanne M., Woodbury, Maya E., Vermeiren, Yannick, Lambourne, Mirjam, Mulder, Jan, Kummer, Markus, Möller, Thomas, Biber, Knut, Dunnen, Wilfred F. A. den, De Deyn, Peter P., Eggen, Bart J. L., Boddeke, Erik W. G. M.

“…Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal…”
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Neuroprotection by Insulin-like Growth Factor-1 in Rats with Ischemic Stroke is Associated with Microglial Changes and a Reduction in Neuroinflammation by Serhan, Ahmad, Aerts, Joeri L., Boddeke, Erik W.G.M., Kooijman, Ron

“…•Post-stroke systemic IGF-1 treatment decreases infarct size and improves sensorimotor function in rats.•The increase in the density of ameboid microglia by…”
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Transcriptomic analysis of purified human cortical microglia reveals age-associated changes by Galatro, Thais F, Holtman, Inge R, Lerario, Antonio M, Vainchtein, Ilia D, Brouwer, Nieske, Sola, Paula R, Veras, Mariana M, Pereira, Tulio F, Leite, Renata E P, Möller, Thomas, Wes, Paul D, Sogayar, Mari C, Laman, Jon D, den Dunnen, Wilfred, Pasqualucci, Carlos A, Oba-Shinjo, Sueli M, Boddeke, Erik W G M, Marie, Suely K N, Eggen, Bart J L

“…Microglia are the macrophages of the CNS, with innate neuroimmune function, and play important roles in tissue homeostasis, CNS development and…”
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Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex by Gerrits, Emma, Giannini, Lucia A. A., Brouwer, Nieske, Melhem, Shamiram, Seilhean, Danielle, Le Ber, Isabelle, Kamermans, Alwin, Kooij, Gijs, de Vries, Helga E., Boddeke, Erik W. G. M., Seelaar, Harro, van Swieten, John C., Eggen, Bart J. L.

“…Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia, affecting predominantly frontal and temporal cerebral lobes…”
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Regionally diverse astrocyte subtypes and their heterogeneous response to EAE by Borggrewe, Malte, Grit, Corien, Vainchtein, Ilia D., Brouwer, Nieske, Wesseling, Evelyn M., Laman, Jon D., Eggen, Bart J. L., Kooistra, Susanne M., Boddeke, Erik W. G. M.

“…Astrocytes fulfil many functions in the central nervous system (CNS), including contribution to the blood brain barrier, synapse formation, and trophic…”
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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis by Holtman, Inge R, Raj, Divya D, Miller, Jeremy A, Schaafsma, Wandert, Yin, Zhuoran, Brouwer, Nieske, Wes, Paul D, Möller, Thomas, Orre, Marie, Kamphuis, Willem, Hol, Elly M, Boddeke, Erik W G M, Eggen, Bart J L

“…Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and…”
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Microglia morphotyping in the adult mouse CNS using hierarchical clustering on principal components reveals regional heterogeneity but no sexual dimorphism by Weering, Hilmar R. J., Nijboer, Tjalling W., Brummer, Maaike L., Boddeke, Erik W. G. M., Eggen, Bart J. L.

“…Microglia are the resident macrophages of the central nervous system (CNS) and play a pivotal role in immune surveillance and CNS homeostasis. Morphological…”
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Prevention of microgliosis halts early memory loss in a mouse model of Alzheimer’s disease by Kater, Mandy S.J., Huffels, Christiaan F.M., Oshima, Takuya, Renckens, Niek S., Middeldorp, Jinte, Boddeke, Erik W.G.M., Smit, August B., Eggen, Bart J.L., Hol, Elly M., Verheijen, Mark H.G.

“…•Microgliosis coincides with increased soluble Aβ42 levels in APP/PS1mice.•Reactivity of microglia is driving early AD progression in APP/PS1 mice.•Therapeutic…”
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Epigenetic regulation of innate immune memory in microglia by Zhang, Xiaoming, Kracht, Laura, Lerario, Antonio M, Dubbelaar, Marissa L, Brouwer, Nieske, Wesseling, Evelyn M, Boddeke, Erik W G M, Eggen, Bart J L, Kooistra, Susanne M

“…Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a…”
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Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View by Eggen, Bart J.L., Boddeke, Erik W.G.M., Kooistra, Susanne M.

“…[Display omitted] •Microglia serve a wide variety of functions in the CNS, in health and disease.•Recent technological advances elucidated many aspects of…”
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