Search Results - "Boczkowski, David"

Vaccination against the forkhead family transcription factor foxp3 enhances tumor immunity by NAIR, Smita, BOCZKOWSKI, David, FASSNACHT, Martin, PISETSKY, David, GILBOA, Eli

“…Depletion of CD4+CD25+ regulatory T cells (Treg) by treatment with alphaCD25 antibody synergizes with vaccination protocols to engender protective immunity in…”
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Functional reprogramming of peripheral blood monocytes by soluble mediators in patients with pancreatic cancer and intraductal papillary mucinous neoplasms by Eckhoff, Austin M, Brown, Michael C, Landa, Karenia, Naqvi, Ibtehaj, Holl, Eda K, Boczkowski, David, Fletcher, Ashley, Rhodin, Kristen E, Giang, Minh Huy, Sullenger, Bruce, Beasley, Georgia M, Allen, Peter J, Nair, Smita K

“…Monocytes and monocyte-derived tumor infiltrating cells have been implicated in the immunosuppression and immune evasion associated with pancreatic…”
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Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis by Therien, Aaron D, Beasley, Georgia M, Rhodin, Kristen E, Farrow, Norma E, Tyler, Douglas S, Boczkowski, David, Al-Rohil, Rami N, Holl, Eda K, Nair, Smita K

“…B cells are key regulators of immune responses in melanoma. We aimed to explore differences in the histologic location and activation status of B cell…”
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Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts by LEE, Jaewoo, FASSNACHT, Martin, NAIR, Smita, BOCZKOWSKI, David, GILBOA, Eli

“…Murine studies have shown that immunologic targeting of the tumor vasculature, a key element of the tumor stroma, can lead to protective immunity in the…”
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Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma by Beasley, Georgia M, Brown, Michael C, Farrow, Norma E, Landa, Karenia, Al-Rohil, Rami N, Selim, Maria Angelica, Therien, Aaron D, Jung, Sin-Ho, Gao, Junheng, Boczkowski, David, Holl, Eda K, Salama, April K S, Bigner, Darell D, Gromeier, Matthias, Nair, Smita K

“…BackgroundWe previously reported results from a phase 1 study testing intratumoral recombinant poliovirus, lerapolturev, in 12 melanoma patients. All 12…”
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Synergy between tumor immunotherapy and antiangiogenic therapy by Nair, Smita, Boczkowski, David, Moeller, Benjamin, Dewhirst, Mark, Vieweg, Johannes, Gilboa, Eli

“…This study tested the hypothesis that combination of antiangiogenic therapy and tumor immunotherapy of cancer is synergistic. To inhibit angiogenesis, mice…”
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Immunologic targeting of FOXP3 in inflammatory breast cancer cells by Nair, Smita, Aldrich, Amy J, McDonnell, Eoin, Cheng, Qing, Aggarwal, Anshu, Patel, Pujan, Williams, Monique M, Boczkowski, David, Lyerly, H Kim, Morse, Michael A, Devi, Gayathri R

“…The forkhead transcription factor FOXP3 is necessary for induction of regulatory T lymphocytes (Tregs) and their immunosuppressive function. We have previously…”
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Induction of CD4+ and CD8+ T-Cell Responses to the Human Stromal Antigen, Fibroblast Activation Protein: Implication for Cancer Immunotherapy by FASSNACHT, Martin, LEE, Jaewoo, MILAZZO, Caterina, BOCZKOWSKI, David, ZHEN SU, NAIR, Smita, GILBOA, Eli

“…Purpose: The propensity of tumor cells to escape immune elimination could limit, if not defeat, the long-term benefits of effective immunotherapeutic…”
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Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization by Zhao, Fei, Xiao, Christine, Evans, Kathy S., Theivanthiran, Tbalamayooran, DeVito, Nicholas, Holtzhausen, Alisha, Liu, Juan, Liu, Xiaojing, Boczkowski, David, Nair, Smita, Locasale, Jason W., Hanks, Brent A.

“…Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Emerging evidence indicates that the tolerization of local…”
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Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs by Brown, Michael C, Holl, Eda K, Boczkowski, David, Dobrikova, Elena, Mosaheb, Mubeen, Chandramohan, Vidya, Bigner, Darell D, Gromeier, Matthias, Nair, Smita K

“…Tumors thrive in an immunosuppressive microenvironment that impedes antitumor innate and adaptive immune responses. Thus, approaches that can overcome…”
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The Quest for mRNA Vaccines by Gilboa, Eli, Boczkowski, David, Nair, Smita K

“…The success of mRNA vaccines against COVID-19 is nothing short of a medical revolution. Given its chemical lability the use of mRNA as a therapeutic has been…”
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Cancer mRNA vaccines: clinical advances and future opportunities by Sayour, Elias J., Boczkowski, David, Mitchell, Duane A., Nair, Smita K.

“…mRNA vaccines have been revolutionary in terms of their rapid development and prevention of SARS-CoV-2 infections during the COVID-19 pandemic, and this…”
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Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer by Holl, Eda K., Frazier, Victoria, Landa, Karenia, Boczkowski, David, Sullenger, Bruce, Nair, Smita K.

“…Tumor cells release nucleic acid-containing proinflammatory complexes, termed nucleic acid-containing damage-associated molecular patterns (NA DAMPs),…”
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Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer by Dollins, Claudia M., Nair, Smita, Boczkowski, David, Lee, Jaewoo, Layzer, Juliana M., Gilboa, Eli, Sullenger, Bruce A.

“…We show that a molecular scaffold can be utilized to convert a receptor binding aptamer into a receptor agonist. Many receptors (including tumor necrosis…”
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Targeting DAMP-induced inflammation to prevent breast cancer metastasis and improve anti-tumor immunity by Frazier, Victoria N, Holl, Eda, Boczkowski, David, Sullenger, Bruce, Nair, Smita K

“…Abstract Biomarkers associated with systemic inflammation correlate with poor prognosis in cancer patients. Circulating cell-free DNA (cfDNA) is released…”
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Oncolytic poliovirus immunotherapy for breast cancer by Frazier, Victoria N, Holl, Eda, Brown, Michael, Boczkowski, David, Landa, Karenia, Hwang, Shelley, Gromeier, Matthias, Nair, Smita K

“…Abstract Oncolytic poliovirus PVSRIPO is a recombinant, non-pathogenic polio:rhinovirus chimera that enters cells via the poliovirus receptor CD155. CD155…”
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RNA as performance-enhancers for dendritic cells by Boczkowski, David, Nair, Smita

“…Although studies have demonstrated that antigen-loaded dendritic cells (DC) elicit antigen-specific immune responses, the clinical benefit from DC-based cancer…”
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Abstract P3-01-03: Modulating inflammation with nucleic acid scavengers to prevent breast cancer metastasis by Nair, Smita, Holl, Eda, Landa, Karenia, Frazier, Victoria, Eteshola, Elias, Boczkowski, David, Rempel, Rachel, Hwang, Shelley, Sullenger, Bruce

“…Abstract Rationale: Chronic inflammation is a hallmark of cancer. Inflammation, whether it is an underlying baseline condition or induced/exacerbated due to…”
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Targeting inflammation to prevent breast cancer metastasis by Holl, Eda K., Frazier, Victoria, Boczkowski, David, Sullenger, Bruce, Nair, Smita K.

“…Abstract Biomarkers associated with systemic inflammation correlate with poor prognosis in cancer patients. Circulating cell-free DNA (cfDNA) is released…”
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Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells by NAIR, Smita K, DE LEON, Gabriel, SAMPSON, John H, MITCHELL, Duane A, BOCZKOWSKI, David, SCHMITTLING, Robert, WEIHUA XIE, STAATS, Janet, LIU, Rebecca, JOHNSON, Laura A, WEINHOLD, Kent, ARCHER, Gary E

“…Despite aggressive conventional therapy, glioblastoma (GBM) remains uniformly lethal. Immunotherapy, in which the immune system is harnessed to specifically…”
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