Search Results - "Bockmann, Jan Hendrik"

The challenge of protecting without overprotecting: The two sides of myeloid‐derived suppressor cells in hepatitis B viral infection by Dandri, Maura, Bockmann, Jan‐Hendrik

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Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73 - Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes by Ahmadi, Parimah, Hartjen, Philip, Kohsar, Matin, Kummer, Silke, Schmiedel, Stefan, Bockmann, Jan-Hendrik, Fathi, Anahita, Huber, Samuel, Haag, Friedrich, Schulze Zur Wiesch, Julian

“…The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the…”
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Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis by Wittner, Melanie, Schlicker, Veronika, Libera, Jana, Bockmann, Jan-Hendrik, Horvatits, Thomas, Seiz, Oliver, Kummer, Silke, Manthey, Carolin F, Hüfner, Anja, Kantowski, Marcus, Rösch, Thomas, Degen, Olaf, Huber, Samuel, Eberhard, Johanna M, Schulze Zur Wiesch, Julian

“…Anti-α4β7 therapy with vedolizumab (VDZ) has been suggested as possible immune intervention in HIV. Relatively little is known about the α4β7-integrin (α4β7)…”
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High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection: longitudinal analysis of a German cohort by Bockmann, Jan-Hendrik, Grube, Marcel, Hamed, Vanessa, von Felden, Johann, Landahl, Johanna, Wehmeyer, Malte, Giersch, Katja, Hall, Michaela T, Murray, John M, Dandri, Maura, Lüth, Stefan, Lohse, Ansgar W, Lütgehetmann, Marc, Schulze Zur Wiesch, Julian

“…Chronic hepatitis delta virus (HDV) infection causes severe liver disease which often leads to cirrhosis and hepatocellular carcinoma (HCC). Aim of this study…”
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Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure by Bockmann, Jan-Hendrik, Dandri, Maura, Lüth, Stefan, Pannicke, Nadine, Lohse, Ansgar W

“…Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic infection.Guidelines…”
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Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D by Hermanussen, Lennart, Lampalzer, Sibylle, Bockmann, Jan-Hendrik, Ziegler, Annerose E, Piecha, Felix, Dandri, Maura, Pischke, Sven, Haag, Friedrich, Lohse, Ansgar W, Lütgehetmann, Marc, Weiler-Normann, Christina, Zur Wiesch, Julian Schulze

“…Infections with hepatotropic viruses are associated with various immune phenomena. Hepatitis D virus (HDV) causes the most severe form of viral hepatitis…”
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Clinical establishment of a laboratory developed quantitative HDV PCR assay on the cobas6800 high-throughput system by Pflüger, Lisa Sophie, Nörz, Dominik, Volz, Tassilo, Giersch, Katja, Giese, Annika, Goldmann, Nora, Glebe, Dieter, Bockmann, Jan-Hendrik, Pfefferle, Susanne, Dandri, Maura, Schulze zur Wiesch, Julian, Lütgehetmann, Marc

“…Currently available HDV PCR assays are characterized by considerable run-to-run and inter-laboratory variability. Hence, we established a quantitative reverse…”
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High Rates of Liver Cirrhosis and Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Metabolic and Cardiovascular Comorbidities by Bockmann, Jan-Hendrik, Kohsar, Matin, Murray, John M, Hamed, Vanessa, Dandri, Maura, Lüth, Stefan, Lohse, Ansgar W, Schulze-Zur-Wiesch, Julian

“…The prevalence of metabolic and cardiovascular diseases is rising worldwide. However, little is known about the impact of such disorders on hepatic disease…”
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Blocking viral entry with bulevirtide reduces the number of HDV-infected hepatocytes in human liver biopsies by Allweiss, Lena, Volmari, Annika, Suri, Vithika, Wallin, Jeffrey J, Flaherty, John F, Manuilov, Dmitry, Downie, Bryan, Lütgehetmann, Marc, Bockmann, Jan-Hendrik, Urban, Stephan, Wedemeyer, Heiner, Dandri, Maura

“…Bulevirtide (BLV) is a first-in-class entry inhibitor and the only approved treatment for patients chronically infected with HDV in Europe. We aimed to…”
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CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X by Karimova, Madina, Beschorner, Niklas, Dammermann, Werner, Chemnitz, Jan, Indenbirken, Daniela, Bockmann, Jan-Hendrik, Grundhoff, Adam, Lüth, Stefan, Buchholz, Frank, Wiesch, Julian Schulze zur, Hauber, Joachim

“…Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which…”
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T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice by Dargel, Christina, Bassani-Sternberg, Michal, Hasreiter, Julia, Zani, Fabio, Bockmann, Jan-Hendrik, Thiele, Frank, Bohne, Felix, Wisskirchen, Karin, Wilde, Susanne, Sprinzl, Martin F, Schendel, Dolores J, Krackhardt, Angela M, Uckert, Wolfgang, Wohlleber, Dirk, Schiemann, Matthias, Stemmer, Kerstin, Heikenwälder, Mathias, Busch, Dirk H, Richter, Günther, Mann, Matthias, Protzer, Ulrike

“…Background & Aims Cancer therapies are being developed based on our ability to direct T cells against tumor antigens. Glypican-3 (GPC3) is expressed by 75% of…”
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Comparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus-Infected Hepatocytes by Bockmann, Jan-Hendrik, Stadler, Daniela, Xia, Yuchen, Ko, Chunkyu, Wettengel, Jochen M, Schulze Zur Wiesch, Julian, Dandri, Maura, Protzer, Ulrike

“…Type III interferons (IFNs) (λ1-3) activate similar signaling cascades as type I IFNs (α and β) via different receptors. Since IFN-α and lymphotoxin-β activate…”
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Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication by Hösel, Marianna, Quasdorff, Maria, Ringelhan, Marc, Kashkar, Hamid, Debey-Pascher, Svenja, Sprinzl, Martin F, Bockmann, Jan-Hendrik, Arzberger, Silke, Webb, Dennis, von Olshausen, Gesa, Weber, Achim, Schultze, Joachim L, Büning, Hildegard, Heikenwalder, Mathias, Protzer, Ulrike

“…Background & Aims The human hepatitis B virus (HBV) is a major cause of chronic hepatitis and hepatocellular carcinoma, but molecular mechanisms driving liver…”
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T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice by Quitt, Oliver, Luo, Shanshan, Meyer, Marten, Xie, Zhe, Golsaz-Shirazi, Forough, Loffredo-Verde, Eva, Festag, Julia, Bockmann, Jan Hendrik, Zhao, Lili, Stadler, Daniela, Chou, Wen-Min, Tedjokusumo, Raindy, Wettengel, Jochen Martin, Ko, Chunkyu, Noeßner, Elfriede, Bulbuc, Nadja, Shokri, Fazel, Lüttgau, Sandra, Heikenwälder, Mathias, Bohne, Felix, Moldenhauer, Gerhard, Momburg, Frank, Protzer, Ulrike

“…Current antiviral therapies control but rarely eliminate HBV, leaving chronic HBV carriers at risk of developing hepatocellular carcinoma (HCC). Lacking or…”
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FRI359 - Hepatitis D coinfection is associated with enhanced CXCR3 receptor expression of CD4 memory T cells and intrahepatic CXCR3 ligand expression compared to chronic hepatitis B patients by Bockmann, Jan-Hendrik, Kohsar, Matin, Giersch, Katja, Allweiss, Lena, Kah, Janine, Volz, Tassilo, Ackermann, Christin, Pirosu, Andrea, Lutgehetmann, Marc, Lohse, Ansgar W., zur Wiesch, Julian Schulze, Dandri, Maura

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Hepatitis D coinfection is associated with enhanced CXCR3 receptor expression of CD4 memory T cells and intrahepatic CXCR3 ligand expression compared to chronic hepatitis B patients by Bockmann, Jan-Hendrik, Kohsar, Matin, Giersch, Katja, Allweiss, Lena, Kah, Janine, Volz, Tassilo, Ackermann, Christin, Pirosu, Andrea, Lutgehetmann, Marc, Lohse, Ansgar W., zur Wiesch, Julian Schulze, Dandri, Maura

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Detection of a Broad Range of Low-Level Major Histocompatibility Complex Class II–Restricted, Hepatitis Delta Virus (HDV)–Specific T-Cell Responses Regardless of Clinical Status by Landahl, Johanna, Bockmann, Jan Hendrik, Scheurich, Christoph, Ackermann, Christin, Matzat, Verena, Heide, Janna, Nuurei, Tungalag, D’Antonio, Gianluca, von Felden, Johann, Sette, Alessandro, Peine, Sven, Lohse, Ansgar W, Luetgehetmann, Marc, Marget, Matthias, Sidney, John, Schulze zur Wiesch, Julian

“…Abstract Background This study aimed to comprehensively define the breadth and specificity of the hepatitis delta virus (HDV)–specific T-cell response in…”
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FRI-134-Comparative analysis of intrahepatic and peripheral chemokine responses in chronic hepatitis B, C and D in vivo by Bockmann, Jan-Hendrik, Kohsar, Matin, Allweiss, Lena, Volz, Tassilo, Kah, Janine, Luetgehmann, Marc, Lohse, Ansgar W., zurWiesch, Julian Schulze, Dandri, Maura

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Comparison of the integrin [alpha]4[beta]7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis by Wittner, Melanie, Schlicker, Veronika, Libera, Jana, Bockmann, Jan-Hendrik, Horvatits, Thomas, Seiz, Oliver, Kummer, Silke, Manthey, Carolin F, Hüfner, Anja, Kantowski, Marcus, Rösch, Thomas, Degen, Olaf, Huber, Samuel, Eberhard, Johanna M, Schulze zur Wiesch, Julian

“…Anti-[alpha]4[beta]7 therapy with vedolizumab (VDZ) has been suggested as possible immune intervention in HIV. Relatively little is known about the…”
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Hepatitis D Virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Bockmann, Jan-Hendrik, Allweiss, Lena, Volmari, Annika, da Fonseca Araújo, David, Kohsar, Matin, Hyrina, Anastasia, Kah, Janine, Song, Zhijuan, Chan, Josolyn, Giersch, Katja, Volz, Tassilo, Lütgehetmann, Marc, Wallin, Jeffrey J., Manuilov, Dmitry, Holdorf, Meghan M., Fletcher, Simon P., Lohse, Ansgar W., Bertoletti, Antonio, Schulze zur Wiesch, Julian, Dandri, Maura

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