Search Results - "Bock, Paul E"

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation by Panizzi, Peter, Nahrendorf, Matthias, Figueiredo, Jose-Luiz, Panizzi, Jennifer, Marinelli, Brett, Iwamoto, Yoshiko, Keliher, Edmund, Maddur, Ashoka A, Waterman, Peter, Kroh, Heather K, Leuschner, Florian, Aikawa, Elena, Swirski, Filip K, Pittet, Mikael J, Hackeng, Tilman M, Fuentes-Prior, Pablo, Schneewind, Olaf, Bock, Paul E, Weissleder, Ralph

“…Infection by coagulase-positive Staphylococcus aureus ( S. aureus ) is the most common cause of acute endocarditis, a destructive and progressive condition of…”
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Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin by Kroh, Heather K, Panizzi, Peter, Bock, Paul E

“…Von Willebrand factor-binding protein (VWbp), secreted by Staphylococcus aureus, displays secondary structural homology to the 3-helix bundle, D1 and D2…”
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Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear by Berny, Michelle A, Munnix, Imke C A, Auger, Jocelyn M, Schols, Saskia E M, Cosemans, Judith M E M, Panizzi, Peter, Bock, Paul E, Watson, Steve P, McCarty, Owen J T, Heemskerk, Johan W M

“…The generation of thrombin is a critical process in the formation of venous thrombi. In isolated plasma under static conditions, phosphatidylserine…”
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Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation by Bode, Wolfram, Bock, Paul E, Friedrich, Rainer, Panizzi, Peter, Fuentes-Prior, Pablo, Richter, Klaus, Verhamme, Ingrid, Anderson, Patricia J, Kawabata, Shun-Ichiro, Huber, Robert

“…Many bacterial pathogens secrete proteins that activate host trypsinogen-like enzyme precursors, most notably the proenzymes of the blood coagulation and…”
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Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function by Huang, Xin, Swanson, Richard, Kroh, Heather K., Bock, Paul E.

“…Current thought holds that factor Xa (FXa) bound in the prothrombinase complex is resistant to regulation by protein protease inhibitors during prothrombin…”
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Rapid-reaction Kinetic Characterization of the Pathway of Streptokinase-Plasmin Catalytic Complex Formation by Verhamme, Ingrid M., Bock, Paul E.

“…Binding of the fibrinolytic proteinase plasmin (Pm) to streptokinase (SK) in a tight stoichiometric complex transforms Pm into a potent proteolytic activator…”
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Signal Recognition Particle Binds to Ribosome-bound Signal Sequences with Fluorescence-detected Subnanomolar Affinity That Does Not Diminish as the Nascent Chain Lengthens by Flanagan, John J, Chen, Jui-Chang, Miao, Yiwei, Shao, Yuanlong, Lin, Jialing, Bock, Paul E, Johnson, Arthur E

“…The binding of signal recognition particle (SRP) to ribosome-bound signal sequences has been characterized directly and quantitatively using fluorescence…”
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The Role of Thrombin Exosites I and II in the Activation of Human Coagulation Factor V by Segers, Kenneth, Dahlbäck, Björn, Bock, Paul E., Tans, Guido, Rosing, Jan, Nicolaes, Gerry A.F.

“…Human blood coagulation Factor V (FV) is a plasma protein with little procoagulant activity. Limited proteolysis at Arg709, Arg1018, and Arg1545 by thrombin or…”
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Ratcheting of the Substrate from the Zymogen to Proteinase Conformations Directs the Sequential Cleavage of Prothrombin by Prothrombinase by Bianchini, Elsa P., Orcutt, Steven J., Panizzi, Peter, Bock, Paul E., Krishnaswamy, Sriram, Esmon, Charles T.

“…Prothrombinase catalyzes thrombin formation by the ordered cleavage of two peptide bonds in prothrombin. Although these bonds are likely ≈36 Å apart,…”
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Coupling of Conformational and Proteolytic Activation in the Kinetic Mechanism of Plasminogen Activation by Streptokinase by Boxrud, Paul D, Bock, Paul E

“…Binding of streptokinase (SK) to plasminogen (Pg) induces conformational activation of the zymogen and initiates its proteolytic conversion to plasmin (Pm)…”
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Mapping of the fibrinogen-binding site on the staphylocoagulase C-terminal repeat region by Maddur, Ashoka A., Voehler, Markus, Panizzi, Peter, Meiler, Jens, Bock, Paul E., Verhamme, Ingrid M.

“…Fibrin (Fbn) deposits are a hallmark of staphylocoagulase (SC)-positive endocarditis. Binding of the N terminus of Staphylococcus aureus SC to host prothrombin…”
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Resolution of Conformational Activation in the Kinetic Mechanism of Plasminogen Activation by Streptokinase by Boxrud, Paul D, Verhamme, Ingrid M, Bock, Paul E

“…Streptokinase (SK) activates plasminogen (Pg) by specific binding and nonproteolytic expression of the Pg catalytic site, initiating Pg proteolysis to form the…”
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The Preferred Pathway of Glycosaminoglycan-accelerated Inactivation of Thrombin by Heparin Cofactor II by Verhamme, Ingrid M., Bock, Paul E., Jackson, Craig M.

“…Thrombin (T) inactivation by the serpin, heparin cofactor II (HCII), is accelerated by the glycosaminoglycans (GAGs) dermatan sulfate (DS) and heparin (H)…”
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Development of coagulation factor probes for the identification of procoagulant circulating tumor cells by Tormoen, Garth W, Cianchetti, Flor A, Bock, Paul E, McCarty, Owen J T

“…Metastatic cancer is associated with a hypercoagulable state, and pathological venous thromboembolic disease is a significant source of morbidity and the…”
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Restricted Active Site Docking by Enzyme-bound Substrate Enforces the Ordered Cleavage of Prothrombin by Prothrombinase by Hacisalihoglu, Ayse, Panizzi, Peter, Bock, Paul E., Camire, Rodney M., Krishnaswamy, Sriram

“…The preferred pathway for prothrombin activation by prothrombinase involves initial cleavage at Arg320 to produce meizothrombin, which is then cleaved at…”
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Expression of Allosteric Linkage between the Sodium Ion Binding Site and Exosite I of Thrombin during Prothrombin Activation by Kroh, Heather K., Tans, Guido, Nicolaes, Gerry A.F., Rosing, Jan, Bock, Paul E.

“…The specificity of thrombin for procoagulant and anticoagulant substrates is regulated allosterically by Na+. Ordered cleavage of prothrombin (ProT) at Arg320…”
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Novel Fluorescent Prothrombin Analogs as Probes of Staphylocoagulase-Prothrombin Interactions by Panizzi, Peter, Friedrich, Rainer, Fuentes-Prior, Pablo, Kroh, Heather K., Briggs, Judy, Tans, Guido, Bode, Wolfram, Bock, Paul E.

“…Staphylocoagulase (SC) is a potent nonproteolytic prothrombin (ProT) activator and the prototype of a newly established zymogen activator and adhesion protein…”
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Rapid Binding of Plasminogen to Streptokinase in a Catalytic Complex Reveals a Three-step Mechanism by Verhamme, Ingrid M., Bock, Paul E.

“…Rapid kinetics demonstrate a three-step pathway of streptokinase (SK) binding to plasminogen (Pg), the zymogen of plasmin (Pm). Formation of a fluorescently…”
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Role of Prothrombin Fragment 1 in the Pathway of Regulatory Exosite I Formation during Conversion of Human Prothrombin to Thrombin by Anderson, Patricia J., Bock, Paul E.

“…Prothrombin (Pro) activation by factor Xa generates the thrombin catalytic site and exosites I and II. The role of fragment 1 (F1) in the pathway of exosite I…”
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Structural Basis for Reduced Staphylocoagulase-mediated Bovine Prothrombin Activation by Friedrich, Rainer, Panizzi, Peter, Kawabata, Shun-Ichiro, Bode, Wolfram, Bock, Paul E., Fuentes-Prior, Pablo

“…Staphylocoagulase (SC) is a protein secreted by the human pathogen, Staphylococcus aureus, that activates human prothrombin (ProT) by inducing a conformational…”
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