Search Results - "Bock, Istvan"

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation by Ochalek, Anna, Mihalik, Balázs, Avci, Hasan X, Chandrasekaran, Abinaya, Téglási, Annamária, Bock, István, Giudice, Maria Lo, Táncos, Zsuzsanna, Molnár, Kinga, László, Lajos, Nielsen, Jørgen E, Holst, Bjørn, Freude, Kristine, Hyttel, Poul, Kobolák, Julianna, Dinnyés, András

“…Alzheimer's disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with…”
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Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres are Suitable for Neurotoxicity Screening by Kobolak, Julianna, Teglasi, Annamaria, Bellak, Tamas, Janstova, Zofia, Molnar, Kinga, Zana, Melinda, Bock, Istvan, Laszlo, Lajos, Dinnyes, Andras

“…We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human iPSCs-derived 3D neurospheres grown in 96-well plate format were…”
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Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states by Dirks, René A M, van Mierlo, Guido, Kerstens, Hindrik H D, Bernardo, Andreia S, Kobolák, Julianna, Bock, István, Maruotti, Julien, Pedersen, Roger A, Dinnyés, András, Huynen, Martijn A, Jouneau, Alice, Marks, Hendrik

“…Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific…”
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Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state by Bernardo, Andreia S, Jouneau, Alice, Marks, Hendrik, Kensche, Philip, Kobolak, Julianna, Freude, Kristine, Hall, Vanessa, Feher, Anita, Polgar, Zsuzsanna, Sartori, Chiara, Bock, Istvan, Louet, Claire, Faial, Tiago, Kerstens, Hindrik H D, Bouissou, Camille, Parsonage, Gregory, Mashayekhi, Kaveh, Smith, James C, Lazzari, Giovanna, Hyttel, Poul, Stunnenberg, Hendrik G, Huynen, Martijn, Pedersen, Roger A, Dinnyes, Andras

“…During early mammalian development, transient pools of pluripotent cells emerge that can be immortalised upon stem cell derivation. The pluripotent state,…”
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Promoter analysis of the rabbit POU5F1 gene and its expression in preimplantation stage embryos by Kobolak, Julianna, Kiss, Katalin, Polgar, Zsuzsanna, Mamo, Solomon, Rogel-Gaillard, Claire, Tancos, Zsuzsanna, Bock, Istvan, Baji, Arpad G, Tar, Krisztina, Pirity, Melinda K, Dinnyes, Andras

“…The POU5F1 gene encodes the octamer-binding transcription factor-4 (Oct4). It is crucial in the regulation of pluripotency during embryonic development and…”
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Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells by Kobolák, Julianna, Molnár, Kinga, Varga, Eszter, Bock, István, Jezsó, Bálint, Téglási, Annamária, Zhou, Shuling, Lo Giudice, Maria, Hoogeveen-Westerveld, Marianne, Pijnappel, WWM Pim, Phanthong, Phetcharat, Varga, Norbert, Kitiyanant, Narisorn, Freude, Kristine, Nakanishi, Hideyuki, László, Lajos, Hyttel, Poul, Dinnyés, András

“…Mucopolysaccharidosis II (MPS II) is a lysosomal storage disorder (LSD), caused by iduronate 2-sulphatase (IDS) enzyme dysfunction. The neuropathology of the…”
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Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord by Lovrics, Anna, Gao, Yu, Juhász, Bianka, Bock, István, Byrne, Helen M, Dinnyés, András, Kovács, Krisztián A

“…We have assembled a network of cell-fate determining transcription factors that play a key role in the specification of the ventral neuronal subtypes of the…”
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Cloning and characterization of rabbit POU5F1, SOX2, KLF4, C-MYC and NANOG pluripotency-associated genes by Táncos, Zsuzsanna, Bock, István, Nemes, Csilla, Kobolák, Julianna, Dinnyés, András

“…While the rabbit (Oryctolagus cuniculus) is an important research model for aspects of human development and disease that cannot be studied in rodents, the…”
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Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages by Snijders, Kirsten E., Fehér, Anita, Táncos, Zsuzsanna, Bock, István, Téglási, Annamária, van den Berk, Linda, Niemeijer, Marije, Bouwman, Peter, Le Dévédec, Sylvia E., Moné, Martijn J., Van Rossom, Rob, Kumar, Manoj, Wilmes, Anja, Jennings, Paul, Verfaillie, Catherine M., Kobolák, Julianna, ter Braak, Bas, Dinnyés, András, van de Water, Bob

“…Tagging of endogenous stress response genes can provide valuable in vitro models for chemical safety assessment. Here, we present the generation and…”
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Targeted next generation sequencing of a panel of autism-related genes identifies an EHMT1 mutation in a Kleefstra syndrome patient with autism and normal intellectual performance by Bock, István, Németh, Krisztina, Pentelényi, Klára, Balicza, Péter, Balázs, Anna, Molnár, Mária Judit, Román, Viktor, Nagy, József, Lévay, György, Kobolák, Julianna, Dinnyés, András

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with unknown genetic and environmental causation in most of the affected individuals…”
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Gene targeting and Calcium handling efficiencies in mouse embryonic stem cell lines by Mamo, Solomon

“…AIM:To compare gene targeting efficiencies,expression profiles,and Ca2+ handling potentials in two widely used mouse embryonic stem cell lines.METHODS:The two…”
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Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient by Nemes, Csilla, Varga, Eszter, Táncos, Zsuzsanna, Bock, István, Francz, Barbara, Kobolák, Julianna, Dinnyés, András

“…Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterised, early onset Alzheimer's disease patient, carries a heterozygous,…”
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Establishment of a rabbit induced pluripotent stem cell (RbiPSC) line using lentiviral delivery of human pluripotency factors by Táncos, Zsuzsanna, Nemes, Csilla, Varga, Eszter, Bock, István, Rungarunlert, Sasitorn, Tharasanit, Theerawat, Techakumphu, Mongkol, Kobolák, Julianna, Dinnyés, András

“…Rabbit Embryonic Fibroblast (RbEF) cells (from Hycole hybrid rabbit foetus) were reprogrammed by lentiviral delivery of a self-silencing hOKSM polycistronic…”
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Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 1-year-old male with pathogenic IDS mutation by Varga, Eszter, Nemes, Csilla, Bock, István, Varga, Norbert, Fehér, Anita, Dinnyés, András, Kobolák, Julianna

“…Peripheral blood was collected from a 1-year-old male patient with an X-linked recessive mutation of Iduronate 2-sulfatase (IDS) gene…”
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Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of Mucopolysaccharidosis type II (MPS II) disorder by Varga, Eszter, Nemes, Csilla, Kovács, Eszter, Bock, István, Varga, Norbert, Fehér, Anita, Dinnyés, András, Kobolák, Julianna

“…Peripheral blood was collected from a 39-year-old unaffected female carrier of an X-linked recessive mutation of Iduronate 2-sulfatase gene…”
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Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD) by Varga, Eszter, Nemes, Csilla, Bock, István, Táncos, Zsuzsanna, Berzsenyi, Sára, Lévay, György, Román, Viktor, Kobolák, Julianna, Dinnyés, András

“…Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterized patient with autism spectrum disorder (ASD). The PMBCs were…”
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Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 3-year-old male with pathogenic IDS mutation by Varga, Eszter, Nemes, Csilla, Bock, István, Varga, Norbert, Fehér, Anita, Kobolák, Julianna, Dinnyés, András

“…Peripheral blood was collected from a 3-year-old male patient with an X-linked recessive mutation of Iduronate 2-sulfatase (IDS) gene…”
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Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 7-year-old male with pathogenic IDS mutation by Varga, Eszter, Nemes, Csilla, Bock, István, Varga, Norbert, Fehér, Anita, Kobolák, Julianna, Dinnyés, András

“…Peripheral blood was collected from a 7-year-old male patient with an X-linked recessive mutation of Iduronate 2-sulfatase (IDS) gene…”
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Establishment of EHMT1 mutant induced pluripotent stem cell (iPSC) line from a 11-year-old Kleefstra syndrome (KS) patient with autism and normal intellectual performance by Varga, Eszter, Nemes, Csilla, Táncos, Zsuzsanna, Bock, István, Berzsenyi, Sára, Lévay, György, Román, Viktor, Kobolák, Julianna, Dinnyés, András

“…Peripheral blood was collected from a clinically characterized female Kleefstra syndrome patient with a heterozygous, de novo, premature termination codon…”
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Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor by Rungarunlert, Sasitorn, Klincumhom, Nuttha, Bock, Istvan, Nemes, Csilla, Techakumphu, Mongkol, Pirity, Melinda K., Dinnyes, Andras

“…Embryoid body (EB) formation is a common intermediate during in vitro differentiation of pluripotent stem cells into specialized cell types. We have optimized…”
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