Search Results - "Bochkov, Valery N"

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance by Uderhardt, Stefan, Herrmann, Martin, Oskolkova, Olga V., Aschermann, Susanne, Bicker, Wolfgang, Ipseiz, Natacha, Sarter, Kerstin, Frey, Benjamin, Rothe, Tobias, Voll, Reinhard, Nimmerjahn, Falk, Bochkov, Valery N., Schett, Georg, Krönke, Gerhard

“…Noninflammatory clearance of apoptotic cells (ACs) is crucial to maintain self-tolerance. Here, we have reported a role for the enzyme 12/15-lipoxygenase…”
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Generation and biological activities of oxidized phospholipids by Bochkov, Valery N, Oskolkova, Olga V, Birukov, Konstantin G, Levonen, Anna-Liisa, Binder, Christoph J, Stöckl, Johannes

“…Glycerophospholipids represent a common class of lipids critically important for integrity of cellular membranes. Oxidation of esterified unsaturated fatty…”
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Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes by Zhao, Yi, Zhang, Cheng-Feng, Rossiter, Heidemarie, Eckhart, Leopold, König, Ulrich, Karner, Susanne, Mildner, Michael, Bochkov, Valery N., Tschachler, Erwin, Gruber, Florian

“…The skin is exposed to environmental insults such as UV light that cause oxidative damage to macromolecules. A centerpiece in the defense against oxidative…”
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Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs by Ke, Yunbo, Karki, Pratap, Kim, Junghyun, Son, Sophia, Berdyshev, Evgeny, Bochkov, Valery N., Birukova, Anna A., Birukov, Konstantin G.

“…ABSTRACT As mechanisms controlling redox homeostasis become impaired with aging, exaggerated oxidant stress may cause disproportional oxidation of cell…”
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A simplified procedure for semi-targeted lipidomic analysis of oxidized phosphatidylcholines induced by UVA irradiation by Gruber, Florian, Bicker, Wolfgang, Oskolkova, Olga V., Tschachler, Erwin, Bochkov, Valery N.

“…Oxidized phospholipids (OxPLs) are increasingly recognized as signaling mediators that are not only markers of oxidative stress but are also “makers” of…”
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Oxidized Phospholipids Regulate Expression of ATF4 and VEGF in Endothelial Cells via NRF2-Dependent Mechanism: Novel Point of Convergence Between Electrophilic and Unfolded Protein Stress Pathways by Afonyushkin, Taras, Oskolkova, Olga V, Philippova, Maria, Resink, Therese J, Erne, Paul, Binder, Bernd R, Bochkov, Valery N

“…OBJECTIVE—The ATF4 arm of the unfolded protein response is increasingly recognized for its relevance to pathology, and in particular to angiogenic reactions…”
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Dual Role of the Antioxidant Enzyme Peroxiredoxin 6 in Skin Carcinogenesis by ROLFS, Frank, HUBER, Marcel, WERNER, Sabine, GRUBER, Florian, BÖHM, Friederike, PFISTER, Herbert J, BOCHKOV, Valery N, TSCHACHLER, Erwin, DUMMER, Reinhard, HOHL, Daniel, SCHÄFER, Matthias

“…The antioxidant enzyme peroxiredoxin 6 (Prdx6) is a key regulator of the cellular redox balance, particularly under stress conditions. We identified Prdx6 as…”
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GRP78 is a novel receptor initiating a vascular barrier protective response to oxidized phospholipids by Birukova, Anna A, Singleton, Patrick A, Gawlak, Grzegorz, Tian, Xinyong, Mirzapoiazova, Tamara, Mambetsariev, Bolot, Dubrovskyi, Oleksii, Oskolkova, Olga V, Bochkov, Valery N, Birukov, Konstantin G

“…Vascular integrity and the maintenance of blood vessel continuity are fundamental features of the circulatory system maintained through endothelial cell-cell…”
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Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation by Oskolkova, Olga V, Afonyushkin, Taras, Preinerstorfer, Beatrix, Bicker, Wolfgang, von Schlieffen, Elena, Hainzl, Eva, Demyanets, Svitlana, Schabbauer, Gernot, Lindner, Wolfgang, Tselepis, Alexandros D, Wojta, Johann, Binder, Bernd R, Bochkov, Valery N

“…Polyunsaturated fatty acids are precursors of multiple pro- and anti-inflammatory molecules generated by enzymatic stereospecific and positionally specific…”
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Expression of Heme Oxygenase-1 in Human Vascular Cells Is Regulated by Peroxisome Proliferator-Activated Receptors by Krönke, Gerhard, Kadl, Alexandra, Ikonomu, Elena, Blüml, Stefan, Fürnkranz, Alexander, Sarembock, Ian J, Bochkov, Valery N, Exner, Markus, Binder, Bernd R, Leitinger, Norbert

“…OBJECTIVE—Activation of peroxisome proliferator-activated receptors (PPARs) by lipid-lowering fibrates and insulin-sensitizing thiazolidinediones inhibits…”
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Inflammatory profile of oxidized phospholipids by Bochkov, Valery N

“…Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of…”
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Incorporation of iloprost in phospholipase-resistant phospholipid scaffold enhances its barrier protective effects on pulmonary endothelium by Oskolkova, Olga, Sarich, Nicolene, Tian, Yufeng, Gawlak, Grzegorz, Meng, Fanyong, Bochkov, Valery N., Berdyshev, Evgeny, Birukova, Anna A., Birukov, Konstantin G.

“…Correction of barrier dysfunction and inflammation in acute lung injury (ALI) represents an important problem. Previous studies demonstrate barrier-protective…”
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A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids by Narzt, Marie-Sophie, Nagelreiter, Ionela-Mariana, Oskolkova, Olga, Bochkov, Valery N, Latreille, Julie, Fedorova, Maria, Ni, Zhixu, Sialana, Fernando J, Lubec, Gert, Filzwieser, Manuel, Laggner, Maria, Bilban, Martin, Mildner, Michael, Tschachler, Erwin, Grillari, Johannes, Gruber, Florian

“…Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators…”
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Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo by Jyrkkänen, Henna-Kaisa, Kansanen, Emilia, Inkala, Matias, Kivelä, Annukka M, Hurttila, Hanna, Heinonen, Suvi E, Goldsteins, Gundars, Jauhiainen, Suvi, Tiainen, Satu, Makkonen, Harri, Oskolkova, Olga, Afonyushkin, Taras, Koistinaho, Jari, Yamamoto, Masayuki, Bochkov, Valery N, Ylä-Herttuala, Seppo, Levonen, Anna-Liisa

“…Besides their well-characterized proinflammatory and proatherogenic effects, oxidized phospholipids, such as oxPAPC (oxidized…”
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Protective role of phospholipid oxidation products in endotoxin-induced tissue damage by Leitinger, Norbert, Bochkov, Valery N, Kadl, Alexandra, Huber, Joakim, Gruber, Florian, Binder, Bernd R

“…Lipopolysaccharide (LPS), an outer-membrane component of Gram-negative bacteria, interacts with LPS-binding protein and CD14, which present LPS to toll-like…”
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Retinal pigment epithelium cells produce VEGF in response to oxidized phospholipids through mechanisms involving ATF4 and protein kinase CK2 by Pollreisz, Andreas, Afonyushkin, Taras, Oskolkova, Olga V., Gruber, Florian, Bochkov, Valery N., Schmidt-Erfurth, Ursula

“…Oxidized phospholipids (OxPLs) are pleiotropic lipid mediators known to induce proangiogenic and proinflammatory cellular effects that are increasingly…”
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ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response by Oskolkova, Olga V., Afonyushkin, Taras, Leitner, Alexander, von Schlieffen, Elena, Gargalovic, Peter S., Lusis, Aldons J., Binder, Bernd R., Bochkov, Valery N.

“…We have shown previously that oxidized phospholipids (OxPLs), known to accumulate in atherosclerotic vessels, stimulate angiogenesis via induction of autocrine…”
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Multi-Hit Inhibition of Circulating and Cell-Associated Components of the Toll-Like Receptor 4 Pathway by Oxidized Phospholipids by VON SCHLIEFFEN, Elena, OSKOLKOVA, Olga V, LEITINGER, Norbert, BINDER, Bemd R, BOCHKOV, Valery N, SCHABBAUER, Gernot, GRUBER, Florian, BLÜML, Stephan, GENEST, Melinda, KADL, Alexandra, MARSIK, Claudia, KNAPP, Sylvia, CHOW, Jesse

“…Oxidized phospholipids (OxPLs) that are abundant in atherosclerotic lesions are increasingly recognized as context-dependent lipid mediators demonstrating both…”
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Oxidized Phospholipids Reduce Vascular Leak and Inflammation in Rat Model of Acute Lung Injury by Nonas, Stephanie, Miller, Ian, Kawkitinarong, Kamon, Chatchavalvanich, Santipongse, Gorshkova, Irina, Bochkov, Valery N, Leitinger, Norbert, Natarajan, Viswanathan, Garcia, Joe G. N, Birukov, Konstantin G

“…Acute inflammation and vascular leak are cardinal features of acute lung injury and the acute respiratory distress syndrome. Nonspecific tissue inflammation…”
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Oxidized Phospholipids Stimulate Angiogenesis Via Autocrine Mechanisms, Implicating a Novel Role for Lipid Oxidation in the Evolution of Atherosclerotic Lesions by Bochkov, Valery N, Philippova, Maria, Oskolkova, Olga, Kadl, Alexandra, Furnkranz, Alexander, Karabeg, Erduan, Afonyushkin, Taras, Gruber, Florian, Breuss, Johannes, Minchenko, Alexander, Mechtcheriakova, Diana, Hohensinner, Philipp, Rychli, Kathrin, Wojta, Johann, Resink, Therese, Erne, Paul, Binder, Bernd R, Leitinger, Norbert

“…Angiogenesis is a common feature observed in advanced atherosclerotic lesions. We hypothesized that oxidized phospholipids (OxPLs), which accumulate in…”
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