Search Results - "Boccone, Paola"

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models by Pignochino, Ymera, Capozzi, Federica, D'Ambrosio, Lorenzo, Dell'Aglio, Carmine, Basiricò, Marco, Canta, Marta, Lorenzato, Annalisa, Vignolo Lutati, Francesca, Aliberti, Sandra, Palesandro, Erica, Boccone, Paola, Galizia, Danilo, Miano, Sara, Chiabotto, Giulia, Napione, Lucia, Gammaitoni, Loretta, Sangiolo, Dario, Benassi, Maria Serena, Pasini, Barbara, Chiorino, Giovanna, Aglietta, Massimo, Grignani, Giovanni

“…Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline…”
Get full text

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group by Grignani, Giovanni, D'Ambrosio, Lorenzo, Pignochino, Ymera, Palmerini, Emanuela, Zucchetti, Massimo, Boccone, Paola, Aliberti, Sandra, Stacchiotti, Silvia, Bertulli, Rossella, Piana, Raimondo, Miano, Sara, Tolomeo, Francesco, Chiabotto, Giulia, Sangiolo, Dario, Pisacane, Alberto, Dei Tos, Angelo Paolo, Novara, Luca, Bartolini, Alice, Marchesi, Emanuela, D'Incalci, Maurizio, Bardelli, Alberto, Picci, Piero, Ferrari, Stefano, Aglietta, Massimo

“…Trabectedin is an alkylating drug with a unique mechanism of action causing single-strand and double-strand DNA breaks that activate DNA damage-response…”
Get full text

Impact of a risk-based follow-up in patients affected by gastrointestinal stromal tumour by D'Ambrosio, Lorenzo, Palesandro, Erica, Boccone, Paola, Tolomeo, Francesco, Miano, Sara, Galizia, Danilo, Manca, Antonio, Chiara, Gabriele, Bertotto, Ilaria, Russo, Filippo, Campanella, Delia, Venesio, Tiziana, Sangiolo, Dario, Pignochino, Ymera, Siatis, Dimitrios, De Simone, Michele, Ferrero, Alessandro, Pisacane, Alberto, Dei Tos, Angelo Paolo, Aliberti, Sandra, Aglietta, Massimo, Grignani, Giovanni

“…Abstract Background Follow-up aims to precociously identify recurrences, metastases or treatment-related adverse events so as to undertake the appropriate…”
Get full text

Abstract 3709: PARP1 expression (PARP1expr) drives synergy between PARP1 inhibitors (PARP1-Is) and trabectedin (TR) by Pignochino, Ymera, Capozzi, Federica, D’ambrosio, Lorenzo, Dell’aglio, Carmine, Basiricò, Marco, Boccone, Paola, Palesandro, Erica, Gammaitoni, Loretta, Sangiolo, Dario, Benassi, Maria Serena, Aglietta, Massimo, Grignani, Giovanni

“…Purpose of study. An attractive strategy to improve antitumor treatments is to inflict cytotoxic DNA damage with chemotherapy, and then impede DNA repair by…”
Get full text

Pattern of relapse in limb/girdle low-grade liposarcoma/atypical lipomatous tumor (ALT) during guidelines-suggested follow up (FU) by Piana, Raimondo, D'Ambrosio, Lorenzo, Maldi, Elena, Boglione, Antonella, Galizia, Danilo, Boffano, Michele, Bellato, Enrico, Albertini, Ugo, Bergnolo, Paola, Boccone, Paola, Palesandro, Erica, Linari, Alessandra, Comandone, Alessandro

“…Abstract only…”
Get full text

C-reactive protein (CRP) and peripheral blood monocyte count (PBMC) in patients (pts) with advanced soft tissue sarcomas (ASTS) treated with trabectedin (TR): correlation with progression-free survival (PFS) by Galizia, Danilo, Boccone, Paola, Miano, Sara, Palesandro, Erica, D'Ambrosio, Lorenzo, Tolomeo, Francesco, Aliberti, Sandra, Bertotto, Ilaria, Gatti, Marco, Manca, Antonio, Aglietta, Massimo, Grignani, Giovanni

“…Abstract only…”
Get full text

A phase 1b trial with the combination of trabectedin and olaparib in relapsed patients (pts) with advanced and unresectable bone and soft tissue sarcomas (BSTS): An Italian Sarcoma Group (ISG) study by Grignani, Giovanni, D'Ambrosio, Lorenzo, Pignochino, Ymera, Palmerini, Emanuela, Zucchetti, Massimo, Boccone, Paola, Aliberti, Sandra, Piana, Raimondo, Palesandro, Erica, Miano, Sara, Stacchiotti, Silvia, Dei Tos, Angelo Paolo, Marchesi, Emanuela, Bertulli, Rossella, D'Incalci, Maurizio, Picci, Piero, Ferrari, Stefano, Aglietta, Massimo

“…Abstract only…”
Get full text

Complete remission of paraneoplastic vanishing bile duct syndrome after the successful treatment of Hodgkin's lymphoma: a case report and review of the literature by Rota Scalabrini, Delia, Caravelli, Daniela, Carnevale Schianca, Fabrizio, D'Ambrosio, Lorenzo, Tolomeo, Francesco, Boccone, Paola, Manca, Antonio, De Rosa, Giovanni, Nuzzo, Annamaria, Aglietta, Massimo, Grignani, Giovanni

“…Vanishing bile duct syndrome has been associated with different pathologic conditions (adverse drug reactions, autoimmune diseases, graft versus host disease,…”
Get full text

Preoperative Tru-Cut biopsy (POB) for the diagnosis of retroperitoneal soft tissue sarcomas (RPS) and risk of local recurrence (LR) compared to primary surgery of the tumor by Boccone, Paola, D'Ambrosio, Lorenzo, Galizia, Danilo, Palesandro, Erica, Aliberti, Sandra, Manca, Antonio, Bertotto, Ilaria, Russo, Filippo, Racca, Manuela, Gatti, Marco, Pignochino, Ymera, Aglietta, Massimo, Grignani, Giovanni

“…Abstract only 10583 Background: Regardless optimal surgery LR is still a major challenge in RPS affecting 60% of the patients (pts). To improve these results…”
Get full text

A risk-based individualized follow-up after complete surgery as an effective procedure to reduce the relapse (R) impact in GIST patients (pts) by Palesandro, Erica, Galizia, Danilo, D'Ambrosio, Lorenzo, Boccone, Paola, Aliberti, Sandra, Venesio, Tiziana, Manca, Antonio, Bertotto, Ilaria, Chiara, Gabriele, Russo, Filippo, Campanella, Delia, Pignochino, Ymera, Aglietta, Massimo, Grignani, Giovanni

“…Abstract only 10552 Background: FU care poses a burden on both pts and health system. FU aims to precociously identify recurrences, metastases or…”
Get full text

Analysis of Hohn (HC) and porth-a-cath (PAC) central venous catheters (CVC) adverse events (AEs) and related costs in advanced soft tissue sarcomas (STS) treated with trabectedin (TR) 24-hour (24-h) infusion therapy by Palesandro, Erica, Boccone, Paola, D'Ambrosio, Lorenzo, Galizia, Danilo, Aliberti, Sandra, Debernardi, Felicino, Bona, Francesco, Manca, Antonio, Anselmetti, Giovanni Carlo, Russo, Filippo, Campanella, Delia, Aglietta, Massimo, Grignani, Giovanni

“…Abstract only e20512 Background: TR is registered as second line in STS. The 24-h infusion schedule showed a better activity profile but a CVC is mandatory to…”
Get full text

Risk of adverse cardiovascular events (CVE) and incident diabetes mellitus (DM) in patients (pts) with prostate cancer (PC) treated with androgen deprivation therapy (ADT): A meta-analysis of adjusted observational results by D'Ambrosio, Lorenzo, Brusa, Federica, D'Ascenzo, Fabrizio, Cavallero, Erica, Biondi-Zoccai, Giuseppe, Boccone, Paola, Bironzo, Paolo, Levin, Glenn N, Eckel, Robert H, Milani, Richard V, Sagalowsky, Arthur I., Gasparini, Mauro, Grignani, Giovanni, Gaita, Fiorenzo, Ciuffreda, Libero, Aglietta, Massimo

“…Abstract only e15192 Background: ADT is a mainstay treatment in pts with PC and is supposedly associated to an unfavorable metabolic and cardiovascular…”
Get full text

Gingival metastasis of a radiotherapy-induced breast angiosarcoma: diagnosis and multidisciplinary treatment achieving a prolonged complete remission by Chiarelli, Alessandro, Boccone, Paola, Goia, Franco, Gatti, Marco, De Rosa, Giovanni, Manca, Antonio, Galizia, Danilo, Aglietta, Massimo, Grignani, Giovanni

“…Angiosarcoma is a rare and highly malignant mesenchymal tumor. Similar to other soft tissue sarcomas, it may arise in any organ, although it occurs more…”
Get full text