Search Results - "Bocchi, D."
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Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes
Published in Proceedings of the National Academy of Sciences - PNAS (23-01-2018)“…Increasing evidence suggests that early neurodevelopmental defects in Huntington’s disease (HD) patients could contribute to the later adult neurodegenerative…”
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Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids
Published in Nature communications (02-08-2024)“…Huntington’s disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism of coexisting still functional and…”
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Striatal infusion of cholesterol promotes dose‐dependent behavioral benefits and exerts disease‐modifying effects in Huntington's disease mice
Published in EMBO molecular medicine (07-10-2020)“…A variety of pathophysiological mechanisms are implicated in Huntington's disease (HD). Among them, reduced cholesterol biosynthesis has been detected in the…”
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In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution
Published in Cell reports methods (19-12-2022)“…Stem cell engineering of striatal medium spiny neurons (MSNs) is a promising strategy to understand diseases affecting the striatum and for cell-replacement…”
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Exercise training improves ambulatory blood pressure but not arterial stiffness in heart transplant recipients
Published in The Journal of heart and lung transplantation (01-05-2015)“…Background Hypertension is the most prevalent comorbidity after heart transplantation (HT). Exercise training (ET) is widely recommended as a key…”
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Rationale and Design of the IRON-HF Study: A Randomized Trial to Assess the Effects of Iron Supplementation in Heart Failure Patients With Anemia
Published in Journal of cardiac failure (01-02-2007)“…Abstract Background Anemia is a common finding in heart failure (HF) patients and has been associated with increased morbidity and mortality. It is generally…”
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Successful Treatment by Transcatheter Aortic Valve Implantation of Severe Aortic Regurgitation in a Patient with Ascending Aorta Prosthesis
Published in Heart, lung & circulation (01-05-2013)“…Severe aortic regurgitation (AR), when intervention is required, is managed by surgical aortic valve replacement (SAVR). Recently, transcatheter aortic valve…”
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