Search Results - "Bocan, T M"

Rapid on-line determination of cholesterol distribution among plasma lipoproteins after high-performance gel filtration chromatography by KIEFT, K. A, BOCAN, T. M. A, KRAUSE, B. R

“…A high-performance gel chromatography (HPGC) system has been developed which allows the unattended on-line determination of lipoprotein cholesterol…”
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The ACAT Inhibitor Avasimibe Reduces Macrophages and Matrix Metalloproteinase Expression in Atherosclerotic Lesions of Hypercholesterolemic Rabbits by Bocan, Thomas M. A, Krause, Brian R, Rosebury, Wendy S, Mueller, Sandra Bak, Lu, Xiaokang, Dagle, Catherine, Major, Terry, Lathia, Chetan, Lee, Helen

“…Given the significance of cholesteryl ester (CE) accumulation in macrophage foam cell formation, we hypothesized that inhibitors of acyl-CoA:cholesterol…”
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Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core by Bocan, TM, Schifani, TA, Guyton, JR

“…The formation of the atherosclerotic lipid-rich core has been elucidated by electron microscopy of the core region in small, raised fibrolipid lesions. The…”
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A specific 15-lipoxygenase inhibitor limits the progression and monocyte–macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit by Bocan, Thomas M.A, Rosebury, Wendy S, Mueller, Sandra Bak, Susan Kuchera, Welch, Kathryn, Daugherty, Alan, Cornicelli, Joseph A

“…Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase…”
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HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit by Bocan, Thomas M.A, Bak Mueller, Sandra, Quenby Brown, Edie, Lee, Peter, Bocan, Michelle J, Rea, Thomas, Pape, Michael E

“…Given the beneficial effects of HMG-CoA reductase and ACAT inhibitors on hypercholesterolemia and atherosclerosis, we hypothesized that coadministration would…”
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Human aortic fibrolipid lesions. Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core by Bocan, TM, Guyton, JR

“…The early development of the lipid-rich core and other features of atherosclerotic fibrous plaques has been elucidated by examining discrete, small regions of…”
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The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation by Bocan, T M, Mueller, S B, Mazur, M J, Uhlendorf, P D, Brown, E Q, Kieft, K A

“…A biochemical, histologic and morphometric evaluation of spontaneous, diet-induced (thoracic aorta) and injury-induced (iliac-femoral) atherosclerotic lesions…”
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Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation by Bocan, T M, Mazur, M J, Mueller, S B, Brown, E Q, Sliskovic, D R, O'Brien, P M, Creswell, M W, Lee, H, Uhlendorf, P D, Roth, B D

“…Atherosclerotic lesion development was assessed in the thoracic aorta and chronically denuded iliac-femoral artery of hypercholesterolemic New Zealand White…”
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Brain neuronal RNA metabolism during acute soman toxication: effects of antidotal pretreatments by DOEBLER, J. A, BOCAN, T. M. A, MOORE, R. A, SHIH, T.-M, ANTHONY, A

“…Effects of various antidotal treatments on neuronal RNA contents and on soman induced RNA and acetylcholinesterase (AChE) depletion were monitored using…”
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α-Substituted Malonester Amides:  Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity by Sliskovic, Drago R, Picard, Joseph A, O'Brien, Patrick M, Liao, Peggy, Roark, W. Howard, Roth, Bruce D, Anderson, Maureen A, Mueller, Sandra Bak, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Reindel, James F, Stanfield, Richard L, Turluck, Daniel, Krause, Brian R

“…We prepared a series of α-substituted malonester amides that were evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in…”
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Molecular sieving and mass spectroscopy reveal enhanced collagen degradation in rabbit atheroma by Chen, Jing, Kindt, Erick, Hallak, Hussein, Peterson, J.Thomas, Rosebury, Wendy S, Hubbel, Andrea M, Bocan, Thomas M, Rekhter, Mark D

“…Background: Collagen degradation is the major mechanism of atherosclerotic plaque destabilization. It is unknown whether collagen breakdown is involved into…”
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Inhibition of acyl-CoA cholesterol O-acyltransferase reduces the cholesteryl ester enrichment of atherosclerotic lesions in the Yucatan micropig by Bocan, T M, Mueller, S B, Uhlendorf, P D, Brown, E Q, Mazur, M J, Black, A E

“…Atherosclerotic lesion development may be altered indirectly by regulating plasma cholesterol or directly by inhibition of acyl-CoA cholesterol…”
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Extracellular lipid deposition in atherosclerosis by Guyton, J R, Klemp, K F, Black, B L, Bocan, T M

“…Atherosclerotic lipid deposits found in the core region of fibrous plaques are almost entirely extracellular, but it is not known whether they are derived from…”
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Interferometric analysis of intrasection and intersection thickness variability associated with cryostat microtomy by Anthony, A, Colurso, G J, Bocan, T M, Doebler, J A

“…Mach-Zehnder interferometric measurements were used to assess the extent of section thickness variability (inter- and intrasection) associated with cryostat…”
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Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation by Bocan, T M, Mueller, S B, Uhlendorf, P D, Newton, R S, Krause, B R

“…Due to the potential importance of acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) in the generation of lipid-filled monocytes-macrophages, the ACAT…”
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Heterocyclic Amides:  Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase with Hypocholesterolemic Activity in Several Species and Antiatherosclerotic Activity in the Rabbit by White, Andrew D, Purchase, Claude F, Picard, Joseph A, Anderson, Maureen K, Bak Mueller, Sandra, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Krause, Brian R, Lee, Peter, Stanfield, Richard L, Reindel, James F

“…A series of heterocyclic amides were synthesized and evaluated as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) in vitro and for cholesterol…”
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Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys by Reindel, J F, Dominick, M A, Bocan, T M, Gough, A W, McGuire, E J

“…PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200…”
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Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation by Cushing, G L, Gaubatz, J W, Nava, M L, Burdick, B J, Bocan, T M, Guyton, J R, Weilbaecher, D, DeBakey, M E, Lawrie, G M, Morrisett, J D

“…Lp[a] is a lipoprotein whose plasma concentration is highly correlated with cardiovascular disease. Its protein moiety, apoLp[a], consists of two large…”
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Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure by PETERSON, J. Thomas, HALLAK, Hussein, JOHNSON, Linda, HUA LI, O'BRIEN, Patrick M, SLISKOVIC, Drago R, BOCAN, Thomas M. A, COKER, Mytsi L, ETOH, Takuma, SPINALE, Francis G

“…Matrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased MMP activity has been observed in left…”
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Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase by Roth, Bruce D, Bocan, Thomas M. A, Blankley, C. John, Chucholowski, Alexander W, Creger, Paul L, Creswell, Mark W, Ferguson, Erika, Newton, Roger S, O'Brien, Patrick

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