Hyperinsulinemia as a factor modifying sensitivity of endometrial carcinoma to hormonal influences

Hyperinsulinemia as a factor modifying sensitivity of endometrial carcinoma to hormonal influences

In 22 patients with endometrial carcinoma, Stage I-III (mean age 57.8 years) with obesity, initial and reactive hyperinsulinemia (during glucose load) was revealed. Significant correlations between values of "peak" and field-square of the insulin secretion curve and cytoplasmatic receptors...

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Bibliographic Details
Published in:European journal of gynaecological oncology Vol. 14; no. 2; p. 127
Main Authors: Vishnevsky, A S, Bobrov JuF, Tsyrlina, E V, Dilman, V M
Format: Journal Article
Language:English
Published: Italy 1993
Subjects:
Endometrial Neoplasms - etiology
Endometrial Neoplasms - metabolism
Fatty Acids, Nonesterified - blood
Female
Glucose Tolerance Test
Humans
Hyperglycemia - complications
Hyperinsulinism - complications
Hyperinsulinism - diagnosis
Hyperinsulinism - metabolism
Insulin - metabolism
Insulin Secretion
Middle Aged
Neoplasms, Hormone-Dependent - etiology
Neoplasms, Hormone-Dependent - metabolism
Obesity - complications
Receptors, Estradiol - biosynthesis
Receptors, Progesterone - biosynthesis
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Summary:In 22 patients with endometrial carcinoma, Stage I-III (mean age 57.8 years) with obesity, initial and reactive hyperinsulinemia (during glucose load) was revealed. Significant correlations between values of "peak" and field-square of the insulin secretion curve and cytoplasmatic receptors to Estradiol and Progesterone in the tumor were found. In a group of the patients with high values of reactive hyperinsulinemia significantly larger amounts of steroid hormone receptors in the tumor were determined as compared to the group of the patients who had low insulinemia values. On considering these data a possible conclusion was reached as to the modifying influence of hyperinsulinemia on sensitivity of endometrial carcinoma to hormone receptor synthesis in the tumor by insulin.
ISSN:0392-2936