Search Results - "Bobes, Raúl J."
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Standardizing an Experimental Murine Model of Extraparenchymal Neurocysticercosis That Immunologically Resembles Human Infection
Published in Brain sciences (01-07-2023)“…Neurocysticercosis (NCC) is endemic in non-developed regions of the world. Two forms of NCC have been described, for which neurological morbidity depends on…”
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An RBD-Based Diagnostic Method Useful for the Surveillance of Protective Immunity against SARS-CoV-2 in the Population
Published in Diagnostics (Basel) (05-07-2022)“…After more than two years, the COVID-19 pandemic is still ongoing and evolving all over the world; human herd immunity against SARS-CoV-2 increases either by…”
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Characterization of S3Pvac anti-cysticercosis vaccine components: implications for the development of an anti-cestodiasis vaccine
Published in PloS one (23-06-2010)“…Cysticercosis and hydatidosis seriously affect human health and are responsible for considerable economic loss in animal husbandry in non-developed and…”
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Plasminogen-binding proteins as an evasion mechanism of the host's innate immunity in infectious diseases
Published in Bioscience reports (31-10-2018)“…Pathogens have developed particular strategies to infect and invade their hosts. Amongst these strategies' figures the modulation of several components of the…”
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Effect of Hydroxyurea on Morphology, Proliferation, and Protein Expression on Taenia crassiceps WFU Strain
Published in International journal of molecular sciences (01-06-2024)“…Flatworms are known for their remarkable regenerative ability, one which depends on totipotent cells known as germinative cells in cestodes. Depletion of…”
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Caveats of chimpanzee ChAdOx1 adenovirus-vectored vaccines to boost anti-SARS-CoV-2 protective immunity in mice
Published in Applied microbiology and biotechnology (01-12-2024)“…Several COVID-19 vaccines use adenovirus vectors to deliver the SARS-CoV-2 spike (S) protein. Immunization with these vaccines promotes immunity against the S…”
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Proteomic Study of Entamoeba histolytica Trophozoites, Cysts, and Cyst-Like Structures
Published in PloS one (26-05-2016)“…The cyst stage of Entamoeba histolytica is a promising therapeutic target against human amoebiasis. Our research team previously reported the production in…”
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Towards the development of an epitope-focused vaccine for SARS-CoV-2
Published in Vaccine (26-10-2022)“…•A RBD-based synthetic peptide was shown safe when injected to mice and hamsters.•The vaccine candidate elicited antibodies that sustained for up to 2 months…”
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Potent Anti-amoebic Effects of Ibogaine, Voacangine and the Root Bark Alkaloid Fraction of Tabernaemontana arborea
Published in Planta medica (01-02-2023)“…Plants of species have several pharmacological activities including antimicrobial effects. Amoebiasis continues to be a public health problem, with increasing…”
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Identification and functional characterization of the siRNA pathway in Taenia crassiceps by silencing Enolase A
Published in Acta tropica (01-01-2022)“…•The gene silencing molecular machinery is expressed and active in Taenia crassiceps.•Silencing of T. crassiceps enolase A (40-90%) was induced using a…”
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Identification and characterization of Taenia solium enolase as a plasminogen-binding protein
Published in Acta tropica (01-06-2018)“…•Taenia solium possess four enolase isoforms.•The emergence of flatworm enolase isoforms (A, B and C) was independent to the emergence of their vertebrate…”
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Synthetic bovine lactoferrin peptide Lfampin kills Entamoeba histolytica trophozoites by necrosis and resolves amoebic intracecal infection in mice
Published in Bioscience reports (31-01-2019)“…Amoebiasis caused by the protozoan parasite remains a public health problem in developing countries, making the identification of new anti-amoebic compounds a…”
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Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers
Published in Pharmaceutics (28-12-2022)“…Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching…”
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The Genomes of Two Strains of Taenia crassiceps the Animal Model for the Study of Human Cysticercosis
Published in Frontiers in cellular and infection microbiology (10-05-2022)“…Human cysticercosis by is the major cause of neurological illness in countries of Africa, Southeast Asia, and the Americas. Publication of four cestode genomes…”
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Intranasal Versus Intravenous Dexamethasone to Treat Hospitalized COVID-19 Patients: A Randomized Multicenter Clinical Trial
Published in Archives of medical research (01-02-2024)“…SARS-CoV2 induces flu-like symptoms that can rapidly progress to severe acute lung injury and even death. The virus also invades the central nervous system…”
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Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR)
Published in Scientific reports (19-05-2015)“…Excretory/Secretory (ES) proteins play an important role in the host-parasite interactions. Experimental identification of ES proteins is time-consuming and…”
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Effect of Transforming Growth Factor-β upon Taenia solium and Taenia crassiceps Cysticerci
Published in Scientific reports (27-09-2017)“…Taeniids exhibit a great adaptive plasticity, which facilitates their establishment, growth, and reproduction in a hostile inflammatory microenvironment…”
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Improvement of cell suspension cultures of transformed and untransformed Carica papaya cell lines, towards the development of an antiparasitic product against the gastrointestinal nematode Haemonchus contortus
Published in Frontiers in cellular and infection microbiology (08-09-2022)“…Parasitic diseases have a major impact on human and animal health worldwide. Despite the availability of effective anti-parasitic drugs, their excessive and…”
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Influence of adjuvants on the amount, specificity and functional activity of antibody response to human influenza vaccine in mice
Published in Molecular immunology (01-07-2021)“…•Adjuvants differentially modify the antibody response and the effectiveness of the influenza vaccine.•Some adjuvants promotes Abs recognition towards amino…”
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The muscle and neural architecture of Taenia crassiceps cysticerci revisited; implications on head-tail polarization of the larvae
Published in Frontiers in cellular and infection microbiology (2024)“…has been used for decades as an experimental model for the study of human and porcine cysticercosis. Even though, its life cycle, tissue organization,…”
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