Search Results - "Bobe, P"

Calcium pyrophosphate dihydrate crystals induce IL-1beta production by monocytes through ATP release- and ROS production-dependent pathways – involvement of potassium efflux by Campillo-Gimenez, L, Renaud, M, Gras, P, Renaudin, F, Mellouk, A, Bobe, P, Combes, C, Cohen-Solal, M, Liote, F, Ea, H.-K

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Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages by Lepoivre, M, Flaman, J M, Bobé, P, Lemaire, G, Henry, Y

“…Nitric oxide (NO) synthesized by macrophages inhibits tumor cell replication. NO also inhibits ribonucleotide reductase, an enzyme essential for DNA synthesis,…”
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Nitric Oxide Mediation of Active Immunosuppression Associated With Graft-Versus-Host Reaction by Bobé, Pierre, Benihoud, Karim, Grandjon, Danièle, Opolon, Paule, Pritchard, Linda Louise, Huchet, Roger

“…In the immunosuppression accompanying the lethal systemic graft-versus-host reaction (GVHR) directed against minor histocompatibility antigens in irradiated…”
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Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice by BENIHOUD, K, ESSELIN, S, PERRICAUDET, M, DESCAMPS, D, JULLIENNE, B, SALONE, B, BOBE, P, BONARDELLE, D, CONNAULT, E, OPOLON, P, SAGGIO, I

“…The immunogenicity of recombinant adenoviruses (Ad) constitutes a major concern for their use in gene therapy. Antibody- and cell-mediated immune responses…”
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MRL/lpr CD4- CD8- and CD8+ T cells, respectively, mediate Fas-dependent and perforin cytotoxic pathways by Benihoud, K, Bonardelle, D, Bobé, P, Kiger, N

“…Autoimmune-prone MRL/lpr mice, homozygous for the lpr mutation, exhibit defective apoptosis and develop generalized lymphoproliferation with the accumulation…”
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Fas-mediated liver damage in MRL hemopoietic chimeras undergoing lpr- mediated graft-versus-host disease by Bobe, P, Bonardelle, D, Reynes, M, Godeau, F, Mahiou, J, Joulin, V, Kiger, N

“…Fas is an apoptosis-signaling receptor that triggers cell death upon binding to its ligand (FasL). Autoimmune-prone MRL/lpr mice, characterized by a…”
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Allogenic MHC class II determinant(s) in MRL/Ipr autoimmune disease- prone mice. Unusual expression of an L1 transposable element creates molecular mimicry by Bobe, P, Benihoud, K, Kiger, N

“…In some aged MRL/Ipr autoimmune disease-prone mice, unexpected reactivity has been observed between lymphoid cells and mAb or polyclonal antibodies directed…”
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Functional and biochemical properties of a mouse placental immunoregulatory factor by Bobé, P, Bleux, C, Kanellopoulos-Langevin, C

“…The authors have a long standing interest in immune regulations which control the absence of rejection of a semi-allogeneic fetus by the mother. A previous…”
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Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice by Benihoud, K, Esselin, S, Descamps, D, Jullienne, B, Salone, B, Bobe, P, Bonardelle, D, Connault, E, Opolon, P, Saggio, I, Perricaudet, M

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Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection by Soler, M. N., Bobé, P., Benihoud, K., Lemaire, G., Roos, B. A., Lausson, S.

“…Background Nitric oxide (NO), produced by NO synthase II (NOS II), is the main mediator of the tumoricidal action of activated macrophages. In the present…”
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Antigen-specific modulation of graft-versus-host reactions by two distinct placental factors by Bobé, P, Kanellopoulos-Langevin, C, Bleux, C, Kinsky, R

“…We have previously shown that two distinct mouse placental fractions (PF) are potent immunomodulators in vivo. A 40 kDa PF induces a marked decrease of plaque…”
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Spontaneous autocytotoxicity against an unexpected H-2d haplotype in MRL/lpr(H-2k) autoimmune disease-prone mice by BOBE, P, GACHELIN, G, KIGER, N

“…The MRL/lpr (H-2k) inbred strain, a model for the autoimmune disease systemic lupus erythematosus, differs from the healthy inbred strain MRL +/+ (H-2k) by…”
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The detection of CR1 mRNA and CR1 antigen identifies the presence of immature podocytes in a case of Wilms' tumor (nephroblastoma) by Appay, M D, Kazatchkine, M, Droz, D, Bobe, P, Bariety, J

“…Wilms' tumors (nephroblastomas) are heterogeneous tumors consisting of proliferating epithelial cells in glomeruloid bodies and tubule formations and of…”
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Deviation of humoral and cellular alloimmune reactions by placental extracts by Duc, H T, Massé, A, Bobé, P, Kinsky, R G, Voisin, G A

“…Modifications of the alloimmune response at both the humoral and the cellular levels by placental extracts (PE) syngeneic to the recipient were studied in the…”
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Modulation of mouse anti-SRBC antibody responses by placental extracts. II. Antigen specificity and regulatory role of B and T cell populations affected by two distinct placental fractions by Bobe, P, Kanellopoulos-Langevin, C, Bleux, C, Voisin, GA

“…Previous results from our group had shown that when CBA mice are primed to sheep red blood cells (SRBC) in the presence of various doses of placental extract…”
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Immunogenetic studies of spontaneous abortion in mice. II. Antiabortive effects are independent of systemic regulatory mechanisms by Bobé, P, Chaouat, G, Stanislawski, M, Kiger, N

“…CBA/J females (H-2k) mated with DBA2/J males (H-2d) exhibit a high rate of fetal resorption. Fetal survival has been improved by pretreatment of CBA/J females…”
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Inflammatory arthropathy in MRL hematopoietic chimeras undergoing Fas mediated graft-versus-host syndrome by BONARDELLE, Danielle, BOBE, Pierre, REYNES, Michel, AMOUROUX, Jacques, TRICOTTET, Viviane, GODEAU, Francois, KIGER, Nicole

“…OBJECTIVE: To determine whether overexpression of the Fas ligand (FasL) on activated lpr T lymphocytes could induce arthritic lesions when grafted into…”
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B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice by Bonardelle, Danielle, Benihoud, Karim, Kiger, Nicole, Bobé, Pierre

“…The Fas/Fas ligand (FasL) pathway is one of the two major effector mechanisms of T cell‐mediated cytotoxicity. To prevent nonspecific killing by lymphoid…”
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Immunogenetic studies of spontaneous abortion in mice. III. Non-H-2 antigens and gestation by Bobé, P, Kiger, N

“…CBA/J (H-2k) females, mated with DBA/2 J (H-2d) or DBA/1 J (H-2q) males, exhibit a high rate of fetal resorption. In contrast, when H-2 identical CBA…”
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Imbalance of MHC class I expression in 3LL tumour cells by Benihoud, K, Lecerf, J M, Bobé, P, Kiger, N

“…Cell lines and a clone established from the C57BL/6 (H-2b) Lewis lung (3LL) tumour were previously characterized with respect to tumour growth and metastatic…”
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