Search Results - "Board, PG"

Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice by Blackburn, AC, Rooke, M, Li, Y, Dahlstrom, JE, Board, PG

“…Doc number: A62…”
Get full text

Nomenclature for mammalian soluble glutathione transferases by Mannervik, Bengt, Board, Philip G, Hayes, John D, Listowsky, Irving, Pearson, William R

“…The nomenclature for human soluble glutathione transferases (GSTs) is extended to include new members of the GST superfamily that have been discovered,…”
Get more information

An efficient system for high‐level expression and easy purification of authentic recombinant proteins by Catanzariti, Ann‐Maree, Soboleva, Tatiana A., Jans, David A., Board, Philip G., Baker, Rohan T.

“…Expression of recombinant proteins as fusions to the eukaryotic protein ubiquitin has been found to significantly increase the yield of unstable or poorly…”
Get full text

Characterization of the omega class of glutathione transferases by Whitbread, Astrid K, Masoumi, Amir, Tetlow, Natasha, Schmuck, Erica, Coggan, Marjorie, Board, Philip G

“…The Omega class of cytosolic glutathione transferases was initially recognized by bioinformatic analysis of human sequence databases, and orthologous sequences…”
Get more information

Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimerʼs and Parkinsonʼs diseases by Schmuck, Erica M, Board, Philip G, Whitbread, Astrid K, Tetlow, Natasha, Cavanaugh, Juleen A, Blackburn, Anneke C, Masoumi, Amir

“…There are two functional Omega class glutathione transferase (GST) genes in humans. GSTO1 is polymorphic with several coding region alleles, including an A140D…”
Get full text

Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases by Board, Philip G., Coggan, Marjorie, Chelvanayagam, Gareth, Easteal, Simon, Jermiin, Lars S., Schulte, Gayle K., Danley, Dennis E., Hoth, Lise R., Griffor, Matthew C., Kamath, Ajith V., Rosner, Michele H., Chrunyk, Boris A., Perregaux, David E., Gabel, Christopher A., Geoghegan, Kieran F., Pandit, Jayvardhan

“…A new class of glutathione transferases has been discovered by analysis of the expressed sequence tag data base and sequence alignment. Glutathione…”
Get full text

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels by Dulhunty, Angela F, Board, Philip G, Beard, Nicole A, Casarotto, Marco G

“…Ryanodine receptor (RyR) ion channels are essential for skeletal and cardiac muscle function. Their knockout leads to perinatal death from respiratory and…”
Get more information

Using deubiquitylating enzymes as research tools by Baker, Rohan T, Catanzariti, Ann-Maree, Karunasekara, Yamuna, Soboleva, Tatiana A, Sharwood, Robert, Whitney, Spencer, Board, Philip G

“…Ubiquitin is synthesized in eukaryotes as a linear fusion with a normal peptide bond either to itself or to one of two ribosomal proteins and, in the latter…”
Get more information

The Val34Leu Polymorphism in the A Subunit of Coagulation Factor XIII Contributes to the Large Normal Range in Activity and Demonstrates That the Activation Peptide Plays a Role in Catalytic Activity by Kangsadalampai, S., Board, P.G.

“…There is a wide normal range of coagulation factor XIII activity that has never been adequately explained. A polymorphism substituting leucine for valine at…”
Get full text

Zeta, a novel class of glutathione transferases in a range of species from plants to humans by Board, P.G, Baker, R.T, Chelvanayagam, G, Jermiin, L.S

“…Sequence alignment and phylogenetic analysis has identified a new subgroup of glutathione S-transferase (GST)-like proteins from a range of species extending…”
Get full text

Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases by Robinson, Anna, Huttley, Gavin A, Booth, Hilary S, Board, Philip G

“…The Kappa class of GSTs (glutathione transferases) comprises soluble enzymes originally isolated from the mitochondrial matrix of rats. We have characterized a…”
Get full text

Human glutathione transferase zeta by Board, Philip G, Anders, M W

“…Zeta-class glutathione transferases (GSTZs) were recently discovered by a bioinformatics approach and the availability of human expressed sequence tag…”
Get more information

Human Monomethylarsonic Acid (MMAV) Reductase Is a Member of the Glutathione-S-transferase Superfamily by Zakharyan, Robert A, Sampayo-Reyes, Adriana, Healy, Sheila M, Tsaprailis, George, Board, Philip G, Liebler, Daniel C, Aposhian, H. Vasken

“…The drinking of water containing large amounts of inorganic arsenic is a worldwide major public health problem because of arsenic carcinogenicity. Yet an…”
Get full text

CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels by Board, Philip G, Coggan, Marjorie, Watson, Sarah, Gage, Peter W, Dulhunty, Angela F

“…We have examined the biochemical and functional properties of the recently identified, uncharacterised CLIC-2 protein. Sequence alignments showed that CLIC-2…”
Get full text

Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways by Blackburn, Anneke C, Matthaei, Klaus I, Lim, Cindy, Taylor, Matthew C, Cappello, Jean Y, Hayes, John D, Anders, M W, Board, Philip G

“…Glutathione S-transferase (GST) zeta (GSTZ1-1) plays a significant role in the catabolism of phenylalanine and tyrosine, and a deficiency of GSTZ1-1 results in…”
Get more information

A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP by Dulhunty, Angela F, Pouliquin, Pierre, Coggan, Marjorie, Gage, Peter W, Board, Philip G

“…The recently discovered CLIC-2 protein (where CLIC stands for chloride intracellular channel), which belongs to the ubiquitous glutathione transferase…”
Get full text

Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid by Tong, Z, Board, P G, Anders, M W

“…Dichloroacetic acid (DCA), a common drinking-water contaminant, is hepatocarcinogenic in rats and mice, and is a therapeutic agent used clinically in the…”
Get full text

Alphavirus 6K Proteins Form Ion Channels by Melton, Julian V., Ewart, Gary D., Weir, Ronald C., Board, Philip G., Lee, Eva, Gage, Peter W.

“…Ross River virus and Barmah Forest virus are Australian arboviruses of the Alphavirus genus. Features of alphavirus infection include an increased permeability…”
Get full text

Crystal Structure of Maleylacetoacetate Isomerase/Glutathione Transferase Zeta Reveals the Molecular Basis for Its Remarkable Catalytic Promiscuity by Polekhina, Galina, Board, Philip G, Blackburn, Anneke C, Parker, Michael W

“…Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization…”
Get full text

Mice Deficient in Glutathione Transferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases by Lim, Cindy E.L., Matthaei, Klaus I., Blackburn, Anneke C., Davis, Richard P., Dahlstrom, Jane E., Koina, Mark E., Anders, M.W., Board, Philip G.

“…Glutathione transferase zeta (GSTZ1-1) is the major enzyme that catalyzes the metabolism of α-halo acids such as dichloroacetic acid, a carcinogenic…”
Get full text