Search Results - "Bo, Yunhai"

A validated HPLC‐MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor by Zhou, Jun, Zhan, Yan, Zhong, Dafang, Chen, Xiaoyan, Zhang, Yifan, Zhang, Qi, Bo, Yunhai, Shen, Lin, Gong, Jifang, Li, Jian, Yang, Fen

“…Simmitecan is a new ester anticancer prodrug which can exert the antiproliferation activity through its active metabolite, chimmitecan. In the current study, a…”
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An intergated serum and urinary metabonomic research based on UPLC-MS and therapeutic effects of Gushudan on prednisolone-induced osteoporosis rats by Huang, Yue, Bo, Yunhai, Wu, Xiao, Wang, Qiuyi, Qin, Feng, Zhao, Longshan, Xiong, Zhili

“…•An intergated serum and urinary metabonomic to study osteoporosis has been proposed.•The mechanism of Gushudan relies on regulating multiple metabolic…”
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A validated UHPLC‐MS/MS method for determination of TQ‐B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor by Yang, Fen, Zhou, Jun, Bo, Yunhai, Yin, Han, Liu, Xiao Hong, Li, Jian

“…TQ‐B3203 is a new topoisomerase I inhibitor derived from camptothecin. In this paper, a simple and reliable ultra high‐performance liquid chromatography‐tandem…”
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Population pharmacokinetic analysis of TQ-B3203 following intravenous administration of TQ-B3203 liposome injection in Chinese patients with advanced solid tumors by Li, Xiaoqing, Bo, Yunhai, Yin, Han, Liu, Xiaohong, Li, Xu, Yang, Fen

“…TQ-B3203 is a novel topoisomerase I inhibitor currently in development for the treatment of advanced solid tumors. Great differences in pharmacokinetic…”
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Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors by Li, Xiaoqing, Bo, Yunhai, Zeng, Qingping, Diao, Lei, Greene, Stephanie, Patterson, John, Liu, Lu, Yang, Fen

“…ORIN1001, a first-in-class oral IRE1-α endoribonuclease inhibitor to block the activation of XBP1, is currently in clinical development for inhibiting tumor…”
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Population Pharmacokinetic Modeling and Simulation of TQ-B3101 to Inform Dosing in Pediatric Patients With Solid Tumors by Yang, Fen, Wu, Huali, Bo, Yunhai, Lu, Ye, Pan, Hong, Li, Su, Lu, Qin, Xie, Simin, Liao, Harry, Wang, Bing

“…TQ-B3101 is a novel kinase inhibitor currently in development for the treatment of advanced malignant solid tumor and relapsed or refractory ALK-positive…”
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Simultaneous Determination of D and L Enantiomers of 2-Hydroxyglutarate by UHPLC-MS/MS Method in Human Biological Fluids and its Clinical Application by Li, Xiaoqing, Bo, Yunhai, Le, Le, Yang, Fen

“…2-hydroxyglutarate has limited abundance in normal tissues but a high level under certain pathologic conditions. To clarify the diagnostic value of two chiral…”
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Plasma metabolomics combined with mass spectrometry imaging reveals crosstalk between tumor and plasma in gastric cancer genesis and metastasis by Chen, Yanhua, Ding, Xian, Zhou, Jun, Wang, Zhaoying, Bo, Yunhai, Hu, Ying, Zang, Qingce, Xu, Jing, Zhang, Ruiping, He, Jiuming, Yang, Fen, Abliz, Zeper

“…Gastric Carcinoma (GC) is a highly fatal malignant tumor with a poor prognosis. Its elevated mortality rates are primarily due to its proclivity for late-stage…”
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Serum metabonomics study of anti-depressive effect of Xiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress by Xiong, Zhili, Yang, Jie, Huang, Yue, Zhang, Kuo, Bo, Yunhai, Lu, Xiumei, Su, Guangyue, Ma, Jie, Yang, Jingyu, Zhao, Longshan, Wu, Chunfu

“…•The potential biomarkers in a chronic unpredictable mild stress model were identified.•Nine metabolites were characterized as potential biomarkers.•The…”
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Development and validation of a UHPLC–MS/MS method for the simultaneous determination of five bioactive flavonoids in rat plasma and comparative pharmacokinetic study after oral administration of Xiaochaihu Tang and three compatibilities by Bo, Yunhai, Wang, Lijuan, Wu, Xiao, Zhao, Longshan, Yang, Jingyu, Xiong, Zhili, Wu, Chunfu

“…An accurate, rapid, and reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed and validated for the…”
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Simultaneous determination of epalrestat and puerarin in rat plasma by UHPLC–MS/MS: Application to their pharmacokinetic interaction study by Sun, Hong, Bo, Yunhai, Zhang, Mingjie, Wu, Xiao, Zhou, Mingyang, Zhao, Longshan, Xiong, Zhili

“…In the present study, a simple, rapid and reliable ultrahigh‐performance liquid chromatography–tandem mass spectrometric (UHPLC–MS/MS) method was developed and…”
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