Search Results - "Blumenthal, Deborah"

Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial by GILBERT, Mark R, MEIHUA WANG, MAHAJAN, Anita, SCHULTZ, Christopher J, ERRIDGE, Sara, BAUMERT, Brigitta, HOPKINS, Kristen I, TZUK-SHINA, Tzahala, BROWN, Paul D, CHAKRAVARTI, Arnab, CURRAN, Walter J, MEHTA, Minesh P, ALDAPE, Kenneth D, STUPP, Roger, HEGI, Monika E, JAECKLE, Kurt A, ARMSTRONG, Terri S, WEFEL, Jeffrey S, MINHEE WON, BLUMENTHAL, Deborah T

“…Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O(6)-methylguanine-DNA…”
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Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma by Mellinghoff, Ingo K., van den Bent, Martin J., Blumenthal, Deborah T., Touat, Mehdi, Peters, Katherine B., Clarke, Jennifer, Mendez, Joe, Yust-Katz, Shlomit, Welsh, Liam, Mason, Warren P., Ducray, François, Umemura, Yoshie, Nabors, Burt, Holdhoff, Matthias, Hottinger, Andreas F., Arakawa, Yoshiki, Sepulveda, Juan M., Wick, Wolfgang, Soffietti, Riccardo, Perry, James R., Giglio, Pierre, de la Fuente, Macarena, Maher, Elizabeth A., Schoenfeld, Steven, Zhao, Dan, Pandya, Shuchi S., Steelman, Lori, Hassan, Islam, Wen, Patrick Y., Cloughesy, Timothy F.

“…Mutations in isocitrate dehydrogenase 1 or 2 are common in low-grade glioma. The IDH inhibitor vorasidenib improved progression-free survival as compared with…”
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Neurologic complications of immune checkpoint inhibitors by Fellner, Avi, Makranz, Chen, Lotem, Michal, Bokstein, Felix, Taliansky, Alisa, Rosenberg, Shai, Blumenthal, Deborah T., Mandel, Jacob, Fichman, Suzana, Kogan, Elena, Steiner, Israel, Siegal, Tali, Lossos, Alexander, Yust-Katz, Shlomit

“…Immune checkpoint inhibitors (ICPIs) have recently emerged as a novel treatment for cancer. These agents, transforming the field of oncology, are not devoid of…”
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Treatment with bevacizumab and irinotecan for recurrent high‐grade glial tumors by Bokstein, Felix, Shpigel, Shulim, Blumenthal, Deborah T.

“…BACKGROUND Response rates to second‐line chemotherapy in recurrent high‐grade glial tumors are low and new effective treatments are needed. The objective of…”
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Pembrolizumab: first experience with recurrent primary central nervous system (CNS) tumors by Blumenthal, Deborah T., Yalon, Michal, Vainer, Gilad W., Lossos, Alexander, Yust, Shlomit, Tzach, Lior, Cagnano, Emanuela, Limon, Dror, Bokstein, Felix

“…Patients with progressive primary brain tumors (PBT) are attracted to promising new treatments, even prior to convincing data. Anti-PD1 immunotherapies have…”
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Differentiation between vasogenic edema and infiltrative tumor in patients with high‐grade gliomas using texture patch‐based analysis by Artzi, Moran, Liberman, Gilad, Blumenthal, Deborah T., Aizenstein, Orna, Bokstein, Felix, Bashat, Dafna

“…Background High‐grade gliomas (HGGs) induce both vasogenic edema and extensive infiltration of tumor cells, both of which present with similar appearance on…”
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An independently validated nomogram for individualized estimation of survival among patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825 by Gittleman, Haley, Lim, Daniel, Kattan, Michael W, Chakravarti, Arnab, Gilbert, Mark R, Lassman, Andrew B, Lo, Simon S, Machtay, Mitchell, Sloan, Andrew E, Sulman, Erik P, Tian, Devin, Vogelbaum, Michael A, Wang, Tony J C, Penas-Prado, Marta, Youssef, Emad, Blumenthal, Deborah T, Zhang, Peixin, Mehta, Minesh P, Barnholtz-Sloan, Jill S

“…Glioblastoma (GBM) is the most common primary malignant brain tumor. Nomograms are often used for individualized estimation of prognosis. This study aimed to…”
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Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG by Blumenthal, Deborah T, Gorlia, Thierry, Gilbert, Mark R, Kim, Michelle M, Burt Nabors, L, Mason, Warren P, Hegi, Monika E, Zhang, Peixin, Golfinopoulos, Vassilis, Perry, James R, Hyun Nam, Do, Erridge, Sara C, Corn, Benjamin W, Mirimanoff, René O, Brown, Paul D, Baumert, Brigitta G, Mehta, Minesh P, van den Bent, Martin J, Reardon, David A, Weller, Michael, Stupp, Roger

“…Radiation with concurrent and adjuvant (6 cycles) temozolomide (TMZ) is the established standard of postsurgical care for newly diagnosed glioblastoma (GBM)…”
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Global post-marketing safety surveillance of Tumor Treating Fields (TTFields) in patients with high-grade glioma in clinical practice by Shi, Wenyin, Blumenthal, Deborah T., Oberheim Bush, Nancy Ann, Kebir, Sied, Lukas, Rimas V., Muragaki, Yoshihiro, Zhu, Jay-Jiguang, Glas, Martin

“…Introduction Tumor Treating Fields (TTFields; antimitotic treatment) delivers low-intensity, intermediate-frequency, alternating electric fields through…”
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MRI radiomics analysis of molecular alterations in low-grade gliomas by Shofty, Ben, Artzi, Moran, Ben Bashat, Dafna, Liberman, Gilad, Haim, Oz, Kashanian, Alon, Bokstein, Felix, Blumenthal, Deborah T., Ram, Zvi, Shahar, Tal

“…Purpose Low-grade gliomas (LGG) are classified into three distinct groups based on their IDH1 mutation and 1p/19q codeletion status, each of which is…”
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Collaborative privacy-preserving analysis of oncological data using multiparty homomorphic encryption by Geva, Ravit, Gusev, Alexander, Polyakov, Yuriy, Liram, Lior, Rosolio, Oded, Alexandru, Andreea, Genise, Nicholas, Blatt, Marcelo, Duchin, Zohar, Waissengrin, Barliz, Mirelman, Dan, Bukstein, Felix, Blumenthal, Deborah T, Wolf, Ido, Pelles-Avraham, Sharon, Schaffer, Tali, Lavi, Lee A, Micciancio, Daniele, Vaikuntanathan, Vinod, Badawi, Ahmad Al, Goldwasser, Shafi

“…Real-world healthcare data sharing is instrumental in constructing broader-based and larger clinical datasets that may improve clinical decision-making…”
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A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine by Latzer, Pauline, Zelba, Henning, Battke, Florian, Reinhardt, Annekathrin, Shao, Borong, Bartsch, Oliver, Rabsteyn, Armin, Harter, Johannes, Schulze, Martin, Okech, Thomas, Golf, Alexander, Kyzirakos-Feger, Christina, Kayser, Simone, Pieper, Natalia, Feldhahn, Magdalena, Wünsche, Julian, Seitz, Christian, Hadaschik, Dirk, Garbe, Claus, Hauser, Till-Karsten, la Fougère, Christian, Biskup, Dirk, Brooke, Dawn, Parker, David, Martens, Uwe M., Illerhaus, Gerald, Blumenthal, Deborah T., Merrell, Ryan, Lorenzo, Luisa Sánchez, Hidvégi, Máté, de Robles, Paula, Kebir, Sied, Li, William W., Li, Vincent W., Williams, Matthew, Miller, Alexandra M., Kesari, Santosh, Castro, Michael, Desjardins, Annick, Ashley, David M., Friedman, Henry S., Wen, Patrick Y., Neil, Elisabeth C., Iwamoto, Fabio M., Sipos, Bence, Geletneky, Karsten, Zender, Lars, Glas, Martin, Reardon, David A., Biskup, Saskia

“…Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal with limited survival. Tumors…”
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Tumor-Treating Fields for the treatment of glioblastoma: a systematic review and meta-analysis by Regev, Ohad, Merkin, Vladimir, Blumenthal, Deborah T, Melamed, Israel, Kaisman-Elbaz, Tehila

“…Abstract Background Tumor-Treating Fields (TTFields) is an emerging treatment modality for glioblastoma (GBM). Studies have shown a good safety profile…”
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Investigating the Effect of Reirradiation or Systemic Therapy in Patients With Glioblastoma After Tumor Progression: A Secondary Analysis of NRG Oncology/Radiation Therapy Oncology Group Trial 0525 by Shi, Wenyin, Scannell Bryan, Molly, Gilbert, Mark R., Mehta, Minesh P., Blumenthal, Deborah T., Brown, Paul D., Valeinis, Egils, Hopkins, Kirsten, Souhami, Luis, Andrews, David W., Tzuk-Shina, Tzahala, Howard, Steve P., Youssef, Emad F., Lessard, Nathalie, Dignam, James J., Werner-Wasik, Maria

“…To determine the impact on overall survival with different salvage therapies, including no treatment, reirradiation, systemic therapy, or radiation and…”
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Differentiation between vasogenic-edema versus tumor-infiltrative area in patients with glioblastoma during bevacizumab therapy: A longitudinal MRI study by Artzi, Moran, Bokstein, Felix, Blumenthal, Deborah T, Aizenstein, Orna, Liberman, Gilad, Corn, Benjamin W, Ben Bashat, Dafna

“…Abstract Background Treatment with bevacizumab is associated with substantial radiologic response in patients with glioblastoma (GB). However, following this…”
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Concurrent Tumor Treating Fields (TTFields) and Radiation Therapy for Newly Diagnosed Glioblastoma: A Prospective Safety and Feasibility Study by Bokstein, Felix, Blumenthal, Deborah, Limon, Dror, Harosh, Carmit Ben, Ram, Zvi, Grossman, Rachel

“…TTFields are a loco-regional, anti-mitotic treatment comprising low-intensity alternating electric fields. In the EF-14 study of newly diagnosed glioblastoma…”
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Differentiation between treatment-related changes and progressive disease in patients with high grade brain tumors using support vector machine classification based on DCE MRI by Artzi, Moran, Liberman, Gilad, Nadav, Guy, Blumenthal, Deborah T., Bokstein, Felix, Aizenstein, Orna, Ben Bashat, Dafna

“…Differentiation between treatment-related changes and progressive disease (PD) remains a major clinical challenge in the follow-up of patients with high grade…”
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Classification of tumor area using combined DCE and DSC MRI in patients with glioblastoma by Artzi, Moran, Blumenthal, Deborah T., Bokstein, Felix, Nadav, Guy, Liberman, Gilad, Aizenstein, Orna, Ben Bashat, Dafna

“…This study proposes an automatic method for identification and quantification of different tissue components: the non-enhanced infiltrative tumor, vasogenic…”
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Safety and efficacy of VB-111, an anticancer gene therapy, in patients with recurrent glioblastoma: results of a phase I/II study by Brenner, Andrew J, Peters, Katherine B, Vredenburgh, James, Bokstein, Felix, Blumenthal, Deborah T, Yust-Katz, Shlomit, Peretz, Idit, Oberman, Bernice, Freedman, Laurence S, Ellingson, Benjamin M, Cloughesy, Timothy F, Sher, Naamit, Cohen, Yael C, Lowenton-Spier, Noa, Rachmilewitz Minei, Tamar, Yakov, Niva, Mendel, Itzhak, Breitbart, Eyal, Wen, Patrick Y

“…Abstract Background VB-111 is a non-replicating adenovirus carrying a Fas-chimera transgene, leading to targeted apoptosis of tumor vascular endothelium and…”
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Impact of contemporary regimens on the outcomes and toxicity of primary CNS lymphoma: a single-center retrospective analysis of 73 patients by Sarid, Nadav, Bokstein, Felix, Blumenthal, Deborah T., Weiss-Meilik, Ahuva, Gibstein, Lili, Avivi, Irit, Perry, Chava, Ram, Ron

“…Introduction Primary central nervous system lymphoma (PCNSL) is a rare disease with a dismal prognosis compared to its systemic large B-cell lymphoma…”
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