Search Results - "Blumel, Jorg"

FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations by Ackley, David, Birkebak, Joanne, Blumel, Jorg, Bourcier, Todd, de Zafra, Christina, Goodwin, Andrew, Halpern, Wendy, Herzyk, Danuta, Kronenberg, Sven, Mauthe, Robert, Shenton, Jacintha, Shuey, Dana, Wange, Ronald L.

“…The nonhuman primate (NHP) has always been a limited resource for pharmaceutical research with ongoing efforts to conserve. This is due to their inherent…”
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Botulinum neurotoxin type A free of complexing proteins (XEOMIN®) in focal dystonia by JOST, Wolfgang H, BLÜMEL, Jörg, GRAFE, Susanne

“…Botulinum neurotoxin type A (BTX-A) weakens voluntary muscle strength and is an effective therapy for focal dystonia, including cervical dystonia (CD) and…”
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Current strategies in the non-clinical safety assessment of biologics: New targets, new molecules, new challenges by Brennan, Frank R., Andrews, Laura, Arulanandam, Antonio R., Blumel, Jorg, Fikes, Jim, Grimaldi, Christine, Lansita, Janice, Loberg, Lise I., MacLachlan, Tim, Milton, Mark, Parker, Suezanne, Tibbitts, Jay, Wolf, Jayanthi, Allamneni, Krishna P.

“…Nonclinical safety testing of biopharmaceuticals can present significant challenges to human risk assessment with these innovative and often complex drugs…”
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An Integrated Model for the Differentiation of Chemical-Induced Allergic and Irritant Skin Reactions by Homey, Bernhard, von Schilling, Christiane, Blümel, Jörg, Schuppe, Hans-Christian, Ruzicka, Thomas, Ahr, Hans Jürgen, Lehmann, Percy, Vohr, Hans-Werner

“…Contact and photocontact allergic as well as irritant and photoirritant skin reactions represent a major problem in clinical dermatology and during the…”
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The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting by Adler, Sarah, Bicker, Gerd, Bigalke, Hans, Bishop, Christopher, Blümel, Jörg, Dressler, Dirk, Fitzgerald, Joan, Gessler, Frank, Heuschen, Heide, Kegel, Birgit, Luch, Andreas, Milne, Catherine, Pickett, Andrew, Ratsch, Heidemarie, Ruhdel, Irmela, Sesardic, Dorothea, Stephens, Martin, Stiens, Gerhard, Thornton, Peter D, Thürmer, René, Vey, Martin, Spielmann, Horst, Grune, Barbara, Liebsch, Manfred

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Analyses of cutaneous fluoroquinolones photoreactivity using the integrated model for the differentiation of skin reactions by Blotz, Andrea, Michel, Laurence, Moysan, Annie, Blümel, Jörg, Dubertret, Louis, Ahr, Hans Jürgen, Vohr, Hans-Werner

“…Currently available test models for the differentiation of photoallergic and photoirritant reactions are extremely time consuming and the protocols are very…”
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Primary immune response in skin and skin-associated lymphoid tissue of interleukin-4 transgenic mice by Blümel, J, Schimpl, A, Ulrich, P, Ahr, H J, Vohr, H

“…The interleukin-4 transgenic mice investigated here exhibit a ubiquitous expression of interleukin-4 in all organs, including the skin. In this study, the…”
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Reduced clostridial protein content by Blümel, Jörg

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