Search Results - "Blume, John"

Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona by Blume, John E., Manning, William C., Troiano, Gregory, Hornburg, Daniel, Figa, Michael, Hesterberg, Lyndal, Platt, Theodore L., Zhao, Xiaoyan, Cuaresma, Rea A., Everley, Patrick A., Ko, Marwin, Liou, Hope, Mahoney, Max, Ferdosi, Shadi, Elgierari, Eltaher M., Stolarczyk, Craig, Tangeysh, Behzad, Xia, Hongwei, Benz, Ryan, Siddiqui, Asim, Carr, Steven A., Ma, Philip, Langer, Robert, Farias, Vivek, Farokhzad, Omid C.

“…Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma proteome. Here we report a highly parallel protein quantitation…”
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Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls by Donovan, Margaret K R, Huang, Yingxiang, Blume, John E, Wang, Jian, Hornburg, Daniel, Ferdosi, Shadi, Mohtashemi, Iman, Kim, Sangtae, Ko, Marwin, Benz, Ryan W, Platt, Theodore L, Batzoglou, Serafim, Diaz, Luis A, Farokhzad, Omid C, Siddiqui, Asim

“…Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers…”
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Ghosts of executions past: A case study of executions in South Carolina in the pre-'Furman' era by Blume, John H

“…During the waning months of the Trump Administration, thirteen persons on federal death row were executed. They all maintained that the lethal injection…”
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HITS-CLIP yields genome-wide insights into brain alternative RNA processing by Darnell, Robert B, Licatalosi, Donny D, Mele, Aldo, Fak, John J, Ule, Jernej, Kayikci, Melis, Chi, Sung Wook, Clark, Tyson A, Schweitzer, Anthony C, Blume, John E, Wang, Xuning, Darnell, Jennifer C

“…Protein–RNA interactions have critical roles in all aspects of gene expression. However, applying biochemical methods to understand such interactions in living…”
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Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano-bio interactions by Ferdosi, Shadi, Tangeysh, Behzad, Brown, Tristan R, Everley, Patrick A, Figa, Michael, McLean, Matthew, Elgierari, Eltaher M, Zhao, Xiaoyan, Garcia, Veder J, Wang, Tianyu, Chang, Matthew E K, Riedesel, Kateryna, Chu, Jessica, Mahoney, Max, Xia, Hongwei, O'Brien, Evan S, Stolarczyk, Craig, Harris, Damian, Platt, Theodore L, Ma, Philip, Goldberg, Martin, Langer, Robert, Flory, Mark R, Benz, Ryan, Tao, Wei, Cuevas, Juan Cruz, Batzoglou, Serafim, Blume, John E, Siddiqui, Asim, Hornburg, Daniel, Farokhzad, Omid C

“…SignificanceDeep profiling of the plasma proteome at scale has been a challenge for traditional approaches. We achieve superior performance across the…”
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Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay by Ni, Julie Z, Grate, Leslie, Donohue, John Paul, Preston, Christine, Nobida, Naomi, O'Brien, Georgeann, Shiue, Lily, Clark, Tyson A, Blume, John E, Ares, Jr, Manuel

“…Many alternative splicing events create RNAs with premature stop codons, suggesting that alternative splicing coupled with nonsense-mediated decay (AS-NMD) may…”
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Quantifying disparate questioning of Black and White jurors in capital jury selection by Effenberger, Anna, Blume, John H., Wells, Martin T.

“…Numerous studies have demonstrated that female and Black jurors are under‐represented on juries in criminal cases, especially so when the prosecution seeks the…”
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The unexonerated: Factually innocent defendants who plead guilty by Blume, John H, Helm, Rebecca K

“…Several recent high profile cases, including the case of the West Memphis Three, have revealed (again) that factually innocent defendants do plead guilty. And,…”
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Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation by Salomonis, Nathan, Schlieve, Christopher R, Pereira, Laura, Wahlquist, Christine, Colas, Alexandre, Zambon, Alexander C, Vranizan, Karen, Spindler, Matthew J, Pico, Alexander R, Cline, Melissa S, Clark, Tyson A, Williams, Alan, Blume, John E, Samal, Eva, Mercola, Mark, Merrill, Bradley J, Conklin, Bruce R

“…Two major goals of regenerative medicine are to reproducibly transform adult somatic cells into a pluripotent state and to control their differentiation into…”
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Discovery of tissue-specific exons using comprehensive human exon microarrays by Clark, Tyson A, Schweitzer, Anthony C, Chen, Tina X, Staples, Michelle K, Lu, Gang, Wang, Hui, Williams, Alan, Blume, John E

“…Higher eukaryotes express a diverse population of messenger RNAs generated by alternative splicing. Large-scale methods for monitoring gene expression must…”
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Identification of Genetic Variants Contributing to Cisplatin-Induced Cytotoxicity by Use of a Genomewide Approach by Huang, R. Stephanie, Duan, Shiwei, Shukla, Sunita J., Kistner, Emily O., Clark, Tyson A., Chen, Tina X., Schweitzer, Anthony C., Blume, John E., Dolan, M. Eileen

“…Cisplatin, a platinating agent commonly used to treat several cancers, is associated with nephrotoxicity, neurotoxicity, and ototoxicity, which has hindered…”
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Integrated detection and population-genetic analysis of SNPs and copy number variation by McCarroll, Steven A, Altshuler, David, Kuruvilla, Finny G, Korn, Joshua M, Cawley, Simon, Nemesh, James, Wysoker, Alec, Shapero, Michael H, de Bakker, Paul I W, Maller, Julian B, Kirby, Andrew, Elliott, Amanda L, Parkin, Melissa, Hubbell, Earl, Webster, Teresa, Mei, Rui, Veitch, James, Collins, Patrick J, Handsaker, Robert, Lincoln, Steve, Nizzari, Marcia, Blume, John, Jones, Keith W, Rava, Rich, Daly, Mark J, Gabriel, Stacey B

“…David Altshuler and colleagues report the design of a hybrid SNP-CNV genotyping array (Affymetrix SNP 6.0 Array) allowing for integrated SNP and CNV detection…”
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A large-scale and robust dynamic MRM study of colorectal cancer biomarkers by You, Jia, Kao, Athit, Dillon, Roslyn, Croner, Lisa J., Benz, Ryan, Blume, John E., Wilcox, Bruce

“…Over the past 20 years, mass spectrometry (MS) has emerged as a dynamic tool for proteomics biomarker discovery. However, published MS biomarker candidates…”
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Unusual intron conservation near tissue-regulated exons found by splicing microarrays by Sugnet, Charles W, Srinivasan, Karpagam, Clark, Tyson A, O'Brien, Georgeann, Cline, Melissa S, Wang, Hui, Williams, Alan, Kulp, David, Blume, John E, Haussler, David, Ares, Jr, Manuel

“…Alternative splicing contributes to both gene regulation and protein diversity. To discover broad relationships between regulation of alternative splicing and…”
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Race, Intellectual Disability, and Death: An Empirical Inquiry Into Invidious Influences on Atkins Determinations by Johnson, Sheri Lynn, Blume, John H, Hritz, Amelia Courtney, Royer, Caisa Elizabeth

“…In Atkins v. Virginia, the U.S. Supreme Court held that the execution of a person with intellectual disability violates the Eighth Amendment's Cruel and…”
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A Genome-Wide Approach to Identify Genetic Variants That Contribute to Etoposide-Induced Cytotoxicity by Huang, R. Stephanie, Duan, Shiwei, Bleibel, Wasim K., Kistner, Emily O., Zhang, Wei, Clark, Tyson A., Chen, Tina X., Schweitzer, Anthony C., Blume, John E., Cox, Nancy J., Dolan, M. Eileen

“…Large interindividual variance has been observed in sensitivity to drugs. To comprehensively decipher the genetic contribution to these variations in drug…”
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Death by Numbers: Why Evolving Standards Compel Extending Roper's Categorical Ban Against Executing Juveniles from Eighteen to Twenty-One by Blume, John H, Freedman, Hannah L, Vann, Lindsey S, Hritz, Amelia Courtney

“…Nearly fifteen years ago, the Supreme Court held in Roper v. Simmons that the Eighth Amendment prohibits the execution of people who were under eighteen at the…”
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"Gideon" Exceptionalism? by BLUME, JOHN H., JOHNSON, SHERI LYNN

“…There is no doubt that Gideon v. Wainwright is extraordinary, but in thinking about its uniqueness, we are reminded of "American exceptionalism" and the…”
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Evaluation of Genetic Variation Contributing to Differences in Gene Expression between Populations by Zhang, Wei, Duan, Shiwei, Kistner, Emily O., Bleibel, Wasim K., Huang, R. Stephanie, Clark, Tyson A., Chen, Tina X., Schweitzer, Anthony C., Blume, John E., Cox, Nancy J., Dolan, M. Eileen

“…Gene expression is a complex quantitative trait partially regulated by genetic variation in DNA sequence. Population differences in gene expression could…”
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Genetic Architecture of Transcript-Level Variation in Humans by Duan, Shiwei, Huang, R. Stephanie, Zhang, Wei, Bleibel, Wasim K., Roe, Cheryl A., Clark, Tyson A., Chen, Tina X., Schweitzer, Anthony C., Blume, John E., Cox, Nancy J., Dolan, M. Eileen

“…We report here the results of testing the pairwise association of 12,747 transcriptional gene-expression values with more than two million single-nucleotide…”
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