Search Results - "Blumberg, Laura C."

Prodrugs of Pioglitazone for Extended-Release (XR) Injectable Formulations by Sanrame, Carlos N, Remenar, Julius F, Blumberg, Laura C, Waters, Julie, Dean, Reginald L, Dong, Nan, Kriksciukaite, Kristi, Cao, Peixin, Almarsson, Örn

“…N-Acyloxymethyl derivatives of pioglitazone (PIO) have been prepared and characterized as model candidates for extended-release injectable formulations. All…”
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Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor by Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Jones, Christopher S., McCurdy, Sandra P., McElroy, Eric, Mitton-Fry, Mark, Munchhof, Michael J., Reim, David A., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Smeets, Marc I., Trevena, Kristen A.

“…5-F substitution of an aminothiazole moiety within a series of thrombopoietin receptor agonists leads to potent agents with an improved hepatic safety profile…”
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The identification of orally bioavailable thrombopoietin agonists by Munchhof, Michael J., Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Wolf-Gouveia, Lilli A., Jones, Christopher S., Li, Qifang, Linde, Robert G., Lira, Paul D., Marfat, Anthony, McElroy, Eric, Mitton-Fry, Mark, McCurdy, Sandra P., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Thomasco, Lisa M., Trevena, Kristen A.

“…Progress towards the identification of bioavailable drug-like thrombopoietin agonist is reported. Recently, we disclosed a series of potent pyrimidine…”
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Pyrimidine benzamide-based thrombopoietin receptor agonists by Reiter, Lawrence A., Subramanyam, Chakrapani, Mangual, Emilio J., Jones, Christopher S., Smeets, Marc I., Brissette, William H., McCurdy, Sandra P., Lira, Paul D., Linde, Robert G., Li, Qifang, Zhang, Fangning, Antipas, Amy S., Blumberg, Laura C., Doty, Jonathan L., Driscoll, James P., Munchhof, Michael J., Ripp, Sharon L., Shavnya, Andrei, Shepard, Richard M., Sperger, Diana, Thomasco, Lisa M., Trevena, Kristen A., Wolf-Gouveia, Lilli A., Zhang, Liling

“…A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group…”
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Piperazinyl CCR1 antagonists—optimization of human liver microsome stability by Brown, Matthew F., Bahnck, Kevin B., Blumberg, Laura C., Brissette, William H., Burrell, Sara A., Driscoll, James P., Fedeles, Flavia, Fisher, Michael B., Foti, Robert S., Gladue, Ronald P., Guzman-Martinez, Aikomari, Hayward, Matthew M., Lira, Paul D., Lillie, Brett M., Lu, Yi, Lundquist, Greg D., McElroy, Eric B., McGlynn, Molly A., Paradis, Timothy J., Poss, Christopher S., Roache, James H., Shavnya, Andrei, Shepard, Richard M., Trevena, Kristen A., Tylaska, Laurie A.

“…The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described. The synthesis, biological activity, and pharmacokinetic…”
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Chemoselective 1,3-dipolar cycloadditions of azomethine ylide with conjugated dienes by Blumberg, Laura C., Costa, Brian, Goldstein, Rebecca

“…Steric and electronic effects on the chemoselectivity are explored. Methods are described of synthesizing various 3-carboxy-4-vinyl pyrrolidines, versatile…”
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