Search Results - "Blumberg, Bruce"

Environmental Obesogens: Mechanisms and Controversies by Heindel, Jerrold J, Blumberg, Bruce

“…Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic…”
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Obesogens: an emerging threat to public health by Janesick, Amanda S., PhD, Blumberg, Bruce, PhD

“…Endocrine disrupting chemicals (EDCs) are defined as exogenous chemicals, or mixtures of chemicals, that can interfere with any aspect of hormone action. The…”
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Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity by Janesick, Amanda, Blumberg, Bruce

“…Obesity and related disorders are a burgeoning public health epidemic, particularly in the U.S. Currently 34% of the U.S. population is clinically obese (BMI >…”
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Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice by Chamorro-Garcia, Raquel, Diaz-Castillo, Carlos, Shoucri, Bassem M., Käch, Heidi, Leavitt, Ron, Shioda, Toshi, Blumberg, Bruce

“…Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant…”
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Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice by Chamorro-García, Raquel, Sahu, Margaret, Abbey, Rachelle J, Laude, Jhyme, Pham, Nhieu, Blumberg, Bruce

“…We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARγ and that prenatal TBT exposure…”
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The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes by Li, Xia, Ycaza, John, Blumberg, Bruce

“…► The RXR–PPARγ heterodimer is permissive for RXR activation in the presence of the PPARγ antagonist GW9662. ► GW9662 is unable to block adipogenesis in 3T3-L1…”
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Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis by Grün, Felix, Blumberg, Bruce

“…The modern world is plagued with expanding epidemics of diseases related to metabolic dysfunction. The factors that are driving obesity, diabetes,…”
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Obesity and endocrine-disrupting chemicals by Amato, Angelica Amorim, Wheeler, Hailey Brit, Blumberg, Bruce

“…Obesity is now a worldwide pandemic. The usual explanation given for the prevalence of obesity is that it results from consumption of a calorie dense diet…”
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Current Research Approaches and Challenges in the Obesogen Field by Chamorro-Garcia, Raquel, Blumberg, Bruce

“…Obesity is a worldwide pandemic that also contributes to the increased incidence of other diseases such as type 2 diabetes. Increased obesity is generally…”
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Prenatal Exposure to the Environmental Obesogen Tributyltin Predisposes Multipotent Stem Cells to Become Adipocytes by Kirchner, Séverine, Kieu, Tiffany, Chow, Connie, Casey, Stephanie, Blumberg, Bruce

“…The environmental obesogen hypothesis proposes that pre- and postnatal exposure to environmental chemicals contributes to adipogenesis and the development of…”
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Transgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Environmental Stressor in Mice by Diaz-Castillo, Carlos, Chamorro-Garcia, Raquel, Shioda, Toshi, Blumberg, Bruce

“…Exposure to environmental stressors is known to increase disease susceptibility in unexposed descendants in the absence of detectable genetic mutations. The…”
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New Modes of Action for Endocrine-Disrupting Chemicals by Tabb, Michelle M, Blumberg, Bruce

“…Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that mimic or block the transcriptional activation elicited by naturally…”
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Transcriptional and Epigenetic Mechanisms Underlying Enhanced in Vitro Adipocyte Differentiation by the Brominated Flame Retardant BDE-47 by Kamstra, Jorke H, Hruba, Eva, Blumberg, Bruce, Janesick, Amanda, Mandrup, Susanne, Hamers, Timo, Legler, Juliette

“…Recent studies suggest that exposure to endocrine-disrupting compounds (EDCs) may play a role in the development of obesity. EDCs such as the flame retardant…”
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Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action by Mohajer, Nicole, Du, Chrislyn Y, Checkcinco, Christian, Blumberg, Bruce

“…Adult and childhood obesity have reached pandemic level proportions. The idea that caloric excess and insufficient levels of physical activity leads to obesity…”
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Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte by Shoucri, Bassem M, Hung, Victor T, Chamorro-García, Raquel, Shioda, Toshi, Blumberg, Bruce

“…Abstract Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for the development of obesity and diabetes later in life. We…”
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Bisphenol A Diglycidyl Ether Induces Adipogenic Differentiation of Multipotent Stromal Stem Cells through a Peroxisome Proliferator―Activated Receptor Gamma-Independent Mechanism by CHAMORRO-GARCIA, Raquel, KIRCHNER, Séverine, XIA LI, JANESICK, Amanda, CASEY, Stephanie C, CHOW, Connie, BLUMBERG, Bruce

“…Bisphenol A (BPA) and bisphenol A diglycidyl ether (BADGE), used in manufacturing coatings and resins, leach from packaging materials into food. Numerous…”
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Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure by Mohajer, Nicole, Joloya, Erika M, Seo, Jeongbin, Shioda, Toshi, Blumberg, Bruce

“…Obesity and metabolic disorders have become a worldwide pandemic affecting millions of people. Although obesity is a multifaceted disease, there is growing…”
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RIPPLY3 is a retinoic acid-inducible repressor required for setting the borders of the pre-placodal ectoderm by Janesick, Amanda, Shiotsugu, Jason, Taketani, Mao, Blumberg, Bruce

“…Retinoic acid signaling is a major component of the neural posteriorizing process in vertebrate development. Here, we identify a new role for the retinoic acid…”
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Znf703 is a novel RA target in the neural plate border by Janesick, Amanda, Tang, Weiyi, Ampig, Kristen, Blumberg, Bruce

“…Znf703 is an RAR- and Wnt-inducible transcription factor that exhibits a complex expression pattern in the developing embryo: Znf703 mRNA is found in the early…”
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Transgenerational metabolomic fingerprints in mice ancestrally exposed to the obesogen TBT by Chamorro-García, Raquel, Poupin, Nathalie, Tremblay-Franco, Marie, Canlet, Cécile, Egusquiza, Riann, Gautier, Roselyne, Jouanin, Isabelle, Shoucri, Bassem M., Blumberg, Bruce, Zalko, Daniel

“…•First application of metabolomics to unveil the transgenerational effects of Tributyltin.•Ancestral (F0) exposure to Tributyltin drives deep metabolic changes…”
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