Search Results - "Blum, Walter"

Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na+/Ca2+ fluxes and the Ca2+-binding protein calretinin by Pecze, László, Blum, Walter, Schwaller, Beat

“…Transient receptor potential vanilloid subtype 1 (TRPV1) receptor is a pain-sensing, ligand-gated, non-selective cation channel expressed in peripheral sensory…”
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How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations by Rehrauer, Hubert, Wu, Licun, Blum, Walter, Pecze, Lazslo, Henzi, Thomas, Serre-Beinier, Véronique, Aquino, Catherine, Vrugt, Bart, de Perrot, Marc, Schwaller, Beat, Felley-Bosco, Emanuela

“…Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor…”
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Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway by Wörthmüller, Janine, Blum, Walter, Pecze, Laszlo, Salicio, Valérie, Schwaller, Beat

“…Calretinin (CR) is used as a positive marker for human malignant mesothelioma (MM) and is essential for mesothelioma cell growth/survival. Yet, the putative…”
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Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin by Wörthmüller, Janine, Salicio, Valérie, Oberson, Anne, Blum, Walter, Schwaller, Beat

“…Malignant mesothelioma (MM) is an aggressive asbestos-linked neoplasm, characterized by dysregulation of signaling pathways. Due to intrinsic or acquired…”
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Parvalbumin‐expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging‐related ventricle stenosis in mice by Filice, Federica, Celio, Marco R., Babalian, Alexandre, Blum, Walter, Szabolcsi, Viktoria

“…Aging‐associated ependymal‐cell pathologies can manifest as ventricular gliosis, ventricle enlargement, or ventricle stenosis. Ventricle stenosis and fusion of…”
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Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter by Blum, Walter, Pecze, László, Rodriguez, Janine Wörthmüller, Steinauer, Martine, Schwaller, Beat

“…The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for the diagnosis of malignant…”
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Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca2+-Binding Proteins Calbindin-D28k and Parvalbumin by Wörthmüller, Janine, Oberson, Anne, Salicio, Valérie, Blum, Walter, Schwaller, Beat

“…Calretinin (CR; CALB2) belonging to the family of EF-hand Ca2+-binding proteins (CaBP) is widely used as a positive marker for the identification of human…”
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Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels by Nazıroğlu, Mustafa, Çiğ, Bilal, Blum, Walter, Vizler, Csaba, Buhala, Andrea, Marton, Annamária, Katona, Róbert, Jósvay, Katalin, Schwaller, Beat, Oláh, Zoltán, Pecze, László

“…There is convincing epidemiological and experimental evidence that capsaicin, a potent natural transient receptor potential cation channel vanilloid member 1…”
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Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma by Wu, Licun, Blum, Walter, Zhu, Chang-Qi, Yun, Zhihong, Pecze, Laszlo, Kohno, Mikihiro, Chan, Mei-Lin, Zhao, Yidan, Felley-Bosco, Emanuela, Schwaller, Beat, de Perrot, Marc

“…Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical…”
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Stem Cell Factor-Based Identification and Functional Properties of In Vitro-Selected Subpopulations of Malignant Mesothelioma Cells by Blum, Walter, Pecze, László, Felley-Bosco, Emanuela, Wu, Licun, de Perrot, Marc, Schwaller, Beat

“…Malignant mesothelioma (MM) is an aggressive neoplasm characterized by a poor patient survival rate, because of rapid tumor recurrence following first-line…”
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Menthol evokes Ca2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells by Nazıroğlu, Mustafa, Blum, Walter, Jósvay, Katalin, Çiğ, Bilal, Henzi, Thomas, Oláh, Zoltán, Vizler, Csaba, Schwaller, Beat, Pecze, László

“…Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic,…”
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Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line by Blum, Walter, Pecze, László, Felley-Bosco, Emanuela, Worthmüller-Rodriguez, Janine, Wu, Licun, Vrugt, Bart, de Perrot, Marc, Schwaller, Beat

“…Mesothelial cells are susceptible to asbestos fiber-induced cytotoxicity and on longer time scales to transformation; the resulting mesothelioma is a highly…”
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SV40-Induced Expression of Calretinin Protects Mesothelial Cells from Asbestos Cytotoxicity and May Be a Key Factor Contributing to Mesothelioma Pathogenesis by Henzi, Thomas, Blum, Walter-Vincent, Pfefferli, Martine, Kawecki, Tadeusz J, Salicio, Valerie, Schwaller, Beat

“…The calcium-binding protein calretinin has emerged as a useful marker for the identification of mesotheliomas of the epithelioid and mixed types, but its…”
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Absence of calretinin protein expression in malignant mesotheliomas from asbestos-exposed NF2 +/- mice and mouse mesothelioma cell lines from various mouse strains by Blum, Walter, Henzi, Thomas, Châtel-Soulet, Hugues-Etienne, Pecze, Laszlo, Rodriguez, Janine Wörthmüller, Vrugt, Bart, Schwaller, Beat

“…Calretinin is the most widespread positive marker for the immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a…”
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Calretinin is essential for mesothelioma cell growth/survival in vitro: A potential new target for malignant mesothelioma therapy? by Blum, Walter, Schwaller, Beat

“…Malignant mesothelioma (MM) are highly aggressive asbestos‐related neoplasms, which show strong chemotherapy resistance, and there is no effective cure for MM…”
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Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin by Pecze, László, Blum, Walter, Schwaller, Beat

“…Transient receptor potential vanilloid subtype 1 (TRPV1) receptor is a pain-sensing, ligand-gated, non-selective cation channel expressed in peripheral sensory…”
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Inducible and reversible silencing of the Pvalb gene in mice: An in vitro and in vivo study by Filice, Federica, Blum, Walter, Lauber, Emanuel, Schwaller, Beat

“…Inducible and reversible regulation of gene expression is a powerful approach for unraveling gene functions. Here, we describe the generation of a system to…”
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Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations by Pecze, László, Blum, Walter, Henzi, Thomas, Schwaller, Beat

“…Sensory neuron subpopulations as well as breast and prostate cancer cells express functional transient receptor potential vanilloid type 1 (TRPV1) ion…”
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Biological noise and positional effects influence cell stemness by Blum, Walter, Henzi, Thomas, Schwaller, Beat, Pecze, László

“…Biological (or cellular) noise is the random quantitative variability of proteins and other molecules in individual, genetically identical cells. As the result…”
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Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca by Pecze, László, Blum, Walter, Schwaller, Beat

“…Background: Ca 2+ oscillations in mesothelial cells depend on Ca 2+ influx. Results: However, the “lanthanum insulation method” renders the oscillations…”
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