Search Results - "Blum, W. F."

Enhancer deletions of the SHOX gene as a frequent cause of short stature: the essential role of a 250 kb downstream regulatory domain by Chen, J, Wildhardt, G, Zhong, Z, Röth, R, Weiss, B, Steinberger, D, Decker, J, Blum, W F, Rappold, G

“…Mutations and deletions of the homeobox transcription factor gene SHOX are known to cause short stature. The authors have analysed SHOX enhancer regions in a…”
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Personalized approach to growth hormone treatment: clinical use of growth prediction models by Wit, J M, Ranke, M B, Albertsson-Wikland, K, Carrascosa, A, Rosenfeld, R G, Van Buuren, S, Kristrom, B, Schoenau, E, Audi, L, Hokken-Koelega, A C S, Bang, P, Jung, H, Blum, W F, Silverman, L A, Cohen, P, Cianfarani, S, Deal, C, Clayton, P E, de Graaff, L, Dahlgren, J, Kleintjens, J, Roelants, M

“…The goal of growth hormone (GH) treatment in a short child is to attain a fast catch-up growth toward the target height (TH) standard deviation score (SDS),…”
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Functional Characterization of a Heterozygous GLI2 Missense Mutation in Patients With Multiple Pituitary Hormone Deficiency by Flemming, G. M. C, Klammt, J, Ambler, G, Bao, Y, Blum, W. F, Cowell, C, Donaghue, K, Howard, N, Kumar, A, Sanchez, J, Stobbe, H, Pfäffle, R. W

“…Context: The GLI2 transcription factor is a major effector protein of the sonic hedgehog pathway and suggested to play a key role in pituitary development…”
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Plasma leptin levels in healthy children and adolescents : Dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone by BLUM, W. F, ENGLARO, P, KIESS, W, RASCHER, W, HANITSCH, S, JUUL, A, HERTEL, N. T, MÜLLER, J, SKAKKEBAEK, N. E, HEIMAN, M. L, BIRKETT, M, ATTANASIO, A. M

“…Leptin, the product of the ob gene, is thought to play a key role in the regulation of body fat mass. Beyond this function, it appears to be an integral…”
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Leptin suppresses semi-starvation induced hyperactivity in rats : implications for anorexia nervosa by EXNER, C, HEBEBRAND, J, KLINGENSPOR, M, REMSCHMIDT, H, WEWETZER, C, ZIEGLER, A, HERPERTZ, S, SCHWEIGER, U, BLUM, W. F, PREIBISCH, G, HELDMAIER, G

“…Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin…”
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Insulin and cortisol promote leptin production in cultured human fat cells by Wabitsch, M., Jensen, P. B., Blum, W. F., Christoffersen, C. T., Englaro, P., Heinze, E., Rascher, W., Teller, W., Tornqvist, H., Hauner, H.

“…Insulin and cortisol promote leptin production in cultured human fat cells. M Wabitsch , P B Jensen , W F Blum , C T Christoffersen , P Englaro , E Heinze , W…”
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Levels of Leptin in Maternal Serum, Amniotic Fluid, and Arterial and Venous Cord Blood: Relation to Neonatal and Placental Weight by Schubring, C, Kiess, W, Englaro, P, Rascher, W, Dötsch, J, Hanitsch, S, Attanasio, A, Blum, W. F

“…The mechanisms by which maternal and fetal weight are regulated during pregnancy are poorly understood. The ob protein, termed leptin, is produced by…”
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Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion by Blum, W F, Albertsson-Wikland, K, Rosberg, S, Ranke, M B

“…The relationship between 24-h GH secretion, insulin-like growth factor (IGF) I serum levels, IGF-binding protein 3 (IGFBP-3) levels and height was studied in…”
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Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: Relation to neonatal and placental weight by SCHUBRING, C, KIESS, W, ENGLARO, P, RASCHER, W, DÖTSCH, J, HANITSCH, S, ATTANASIO, A, BLUM, W. F

“…The mechanisms by which maternal and fetal weight are regulated during pregnancy are poorly understood. The ob protein, termed leptin, is produced by…”
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Serum leptin levels increase rapidly after initiation of clozapine therapy by BRÖMEL, T, BLUM, W. F, ZIEGLER, A, SCHULZ, E, BENDER, M, FLEISCHHAKER, C, REMSCHMIDT, H, KRIEG, J.-C, HEBEBRAND, J

“…Weight gain is a major side-effect of treatment with clozapine. In order to investigate the influence of the atypical neuroleptic clozapine on leptin…”
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Reference values for IGF-I throughout childhood and adolescence: A model that accounts simultaneously for the effect of gender, age, and puberty by LÖFQVIST, Chatarina, ANDERSSON, Eva, GELANDER, Lars, ROSBERG, Sten, BLUM, Werner F, WIKLAND, Kerstin Albertsson

“…We have constructed a reference model to facilitate comparison of serum IGF-I values among children, and thereby to improve the value of IGF-I measurements for…”
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Contribution of androgens to the gender difference in leptin production in obese children and adolescents by Wabitsch, M, Blum, W F, Muche, R, Braun, M, Hube, F, Rascher, W, Heinze, E, Teller, W, Hauner, H

“…Recent studies demonstrated significantly higher serum leptin concentrations in females as compared with males, even after correction for differences in body…”
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Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease : studies in nondiabetic and diabetic subjects by MEYER-SCHWICKERATH, R, PFEIFFER, A, BLUM, W. F, FREYBERGER, H, KLEIN, M, LÖSCHE, C, RÖLLMANN, R, SCHATZ, H

“…Retinal capillary nonperfusion results in neovascularization of the eye, which is restricted to the retina in less severe cases and progresses to the anterior…”
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Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation by Juul, A, Dalgaard, P, Blum, W F, Bang, P, Hall, K, Michaelsen, K F, Müller, J, Skakkebaek, N E

“…Circulating IGF-I and -II are bound to specific insulin-like growth factor (IGF)-binding proteins (IGFBPs), of which IGFBP-3 binds the majority of the IGFs…”
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Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men by JOCKENHÖVEL, F, BLUM, W. F, VOGEL, E, ENGLARO, P, MÜLLER-WIELAND, D, REINWEIN, D, RASCHER, W, KRONE, W

“…The ob gene product leptin (OB) is a feedback signal from the adipocyte to the hypothalamus and is involved in regulation of food intake and energy expenditure…”
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Seasonality of growth response to GH therapy in prepubertal children with idiopathic growth hormone deficiency by Land, C, Blum, W F, Stabrey, A, Schoenau, E

“…Objective: Longitudinal growth of children exhibits seasonal variation. In both healthy children and in children with growth hormone (GH) deficiency (GHD)…”
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Phenotypes in Three Pedigrees with Autosomal Dominant Obesity Caused by Haploinsufficiency Mutations in the Melanocortin-4 Receptor Gene by Sina, Mani, Hinney, Anke, Ziegler, Andreas, Neupert, Tanja, Mayer, Hermann, Siegfried, Wolfgang, Blum, Werner F., Remschmidt, Helmut, Hebebrand, Johannes

“…Recently, haploinsufficiency mutations in the melanocortin-4 receptor gene (MC4-R) were detected which were assumed to lead to the phenotype of extreme…”
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Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity? by BRENNAN, B. M. D, RAHIM, A, BLUM, W. F, ADAMS, J. A, EDEN, O. B, SHALET, S. M

“…OBJECTIVE In order to explore the mechanism of obesity in long‐term survivors of childhood leukaemia, fat mass, lean body mass and serum leptin were assessed…”
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Development and psychometric properties of a disease-specific quality of life questionnaire for adult patients with growth hormone deficiency by HERSCHBACH, P, HENRICH, G, STRASBURGER, C. J, FELDMEIER, H, MARIN, F, ATTANASIO, A. M, BLUM, W. F

“…Adults with growth hormone (GH) deficiency (GHD) may experience physical and psychological disturbances, which can affect their quality of life (QOL). To…”
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Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity by VETTOR, R., DE PERGOLA, G., PAGANO, C., ENGLARO, P., LAUDADIO, E., GIORGINO, F., BLUM, W. F., GIORGINO, R., FEDERSPIL, G.

“…Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being…”
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