Search Results - "Bluestone, Jeffrey A."

Treg cell-based therapies: challenges and perspectives by Raffin, Caroline, Vo, Linda T., Bluestone, Jeffrey A.

“…Cellular therapies using regulatory T (T reg ) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection…”
Get full text

Is autoimmunity the Achilles' heel of cancer immunotherapy? by June, Carl H, Warshauer, Jeremy T, Bluestone, Jeffrey A

“…In this Perspective, June, Bluestone and Warshauer discuss potential cellular and molecular explanations for the autoimmunity often associated with…”
Get full text

CD28 Costimulation: From Mechanism to Therapy by Esensten, Jonathan H., Helou, Ynes A., Chopra, Gaurav, Weiss, Arthur, Bluestone, Jeffrey A.

“…Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here, we…”
Get full text

Immunotherapy: Building a bridge to a cure for type 1 diabetes by Bluestone, Jeffrey A, Buckner, Jane H, Herold, Kevan C

“…Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the insulin-producing β cells in the pancreatic islets. Genetic and…”
Get full text

Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines by Kang, Jee Hye, Bluestone, Jeffrey A., Young, Arabella

“…Cancer immunotherapies can successfully activate immune responses towards certain tumors. However, this can also result in the development of treatment-induced…”
Get full text

Genetics, pathogenesis and clinical interventions in type 1 diabetes by Herold, Kevan, Bluestone, Jeffrey A, Eisenbarth, George

“…Type 1 diabetes is an autoimmune disorder afflicting millions of people worldwide. Once diagnosed, patients require lifelong insulin treatment and can…”
Get full text

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges by Sneddon, Julie B., Tang, Qizhi, Stock, Peter, Bluestone, Jeffrey A., Roy, Shuvo, Desai, Tejal, Hebrok, Matthias

“…Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet…”
Get full text

The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy by Young, Arabella, Quandt, Zoe, Bluestone, Jeffrey A

“…The explosion in novel cancer immunotherapies has resulted in extraordinary clinical successes in the treatment of multiple cancers. Checkpoint inhibitors…”
Get more information

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response by Bailey-Bucktrout, Samantha L., Martinez-Llordella, Marc, Zhou, Xuyu, Anthony, Bryan, Rosenthal, Wendy, Luche, Herve, Fehling, Hans J., Bluestone, Jeffrey A.

“…Stable Foxp3 expression is crucial for regulatory T (Treg) cell function. We observed that antigen-driven activation and inflammation in the CNS promoted Foxp3…”
Get full text

Cell-based therapeutics: the next pillar of medicine by Fischbach, Michael A, Bluestone, Jeffrey A, Lim, Wendell A

“…Two decades ago, the pharmaceutical industry-long dominated by small-molecule drugs-was revolutionized by the the advent of biologics. Today, biomedicine sits…”
Get more information

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation by DuPage, Michel, Chopra, Gaurav, Quiros, Jason, Rosenthal, Wendy L, Morar, Malika M, Holohan, Dan, Zhang, Ruan, Turka, Laurence, Marson, Alexander, Bluestone, Jeffrey A

“…Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling is essential for establishing diverse cellular identities, but how…”
Get full text

Revisiting IL-2: Biology and therapeutic prospects by Abbas, Abul K, Trotta, Eleonora, R Simeonov, Dimitre, Marson, Alexander, Bluestone, Jeffrey A

“…Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell growth factor essential for the proliferation of T cells and the…”
Get more information

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins by Schumann, Kathrin, Lin, Steven, Boyer, Eric, Simeonov, Dimitre R., Subramaniam, Meena, Gate, Rachel E., Haliburton, Genevieve E., Ye, Chun J., Bluestone, Jeffrey A., Doudna, Jennifer A., Marson, Alexander

“…T-cell genome engineering holds great promise for cell-based therapies for cancer, HIV, primary immune deficiencies, and autoimmune diseases, but genetic…”
Get full text

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation by Molofsky, Ari B., Van Gool, Frédéric, Liang, Hong-Erh, Van Dyken, Steven J., Nussbaum, Jesse C., Lee, Jinwoo, Bluestone, Jeffrey A., Locksley, Richard M.

“…Group 2 innate lymphoid cells (ILC2s) and regulatory T (Treg) cells are systemically induced by helminth infection but also sustain metabolic homeostasis in…”
Get full text

Peripherally induced tregs - role in immune homeostasis and autoimmunity by Yadav, Mahesh, Stephan, Stephen, Bluestone, Jeffrey A

“…Thymically derived Foxp3(+) regulatory T cells (tTregs) constitute a unique T cell lineage that is essential for maintaining immune tolerance to self and…”
Get full text

CD3-specific antibodies: a portal to the treatment of autoimmunity by Chatenoud, Lucienne, Bluestone, Jeffrey A

“…Targeted immunotherapies hold great promise for the treatment and cure of autoimmune diseases. The efficacy of CD3-specific monoclonal antibody therapy in mice…”
Get full text

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency by Nguyen, David N., Roth, Theodore L., Li, P. Jonathan, Chen, Peixin Amy, Apathy, Ryan, Mamedov, Murad R., Vo, Linda T., Tobin, Victoria R., Goodman, Daniel, Shifrut, Eric, Bluestone, Jeffrey A., Puck, Jennifer M., Szoka, Francis C., Marson, Alexander

“…Versatile and precise genome modifications are needed to create a wider range of adoptive cellular therapies 1 – 5 . Here we report two improvements that…”
Get full text

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity by Wang, David, Quiros, Jason, Mahuron, Kelly, Pai, Chien-Chun, Ranzani, Valeria, Young, Arabella, Silveria, Stephanie, Harwin, Tory, Abnousian, Arbi, Pagani, Massimiliano, Rosenblum, Michael D., Van Gool, Frederic, Fong, Lawrence, Bluestone, Jeffrey A., DuPage, Michel

“…Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor…”
Get full text

Opportunities for Treg cell therapy for the treatment of human disease by Bluestone, Jeffrey A, McKenzie, Brent S, Beilke, Joshua, Ramsdell, Fred

“…Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammatory diseases. This small…”
Get full text

Pathological conversion of regulatory T cells is associated with loss of allotolerance by Hua, Jing, Inomata, Takenori, Chen, Yihe, Foulsham, William, Stevenson, William, Shiang, Tina, Bluestone, Jeffrey A., Dana, Reza

“…CD4 + CD25 + Foxp3 + Regulatory T cells (Tregs) play a critical role in immune tolerance. The plasticity and functional adaptability of Tregs in an…”
Get full text