Search Results - "Bluestone, J. A."

Clinical Grade Manufacturing of Human Alloantigen‐Reactive Regulatory T Cells for Use in Transplantation by Putnam, A. L., Safinia, N., Medvec, A., Laszkowska, M., Wray, M., Mintz, M. A., Trotta, E., Szot, G. L., Liu, W., Lares, A., Lee, K., Laing, A., Lechler, R. I., Riley, J. L., Bluestone, J. A., Lombardi, G., Tang, Q.

“…Regulatory T cell (Treg) therapy has the potential to induce transplantation tolerance so that immunosuppression and associated morbidity can be minimized…”
Get full text

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation by Bluestone, J. A., Liu, W., Yabu, J. M., Laszik, Z. G., Putnam, A., Belingheri, M., Gross, D. M., Townsend, R. M., Vincenti, F.

“…Regulatory T cells (Treg) are critical regulators of immune tolerance. Both IL‐2 and CD28‐CD80/CD86 signaling are critical for CD4+CD25+FOXP3+ Treg survival in…”
Get full text

CD4+CD25+ Regulatory T Cells in Transplantation: Progress, Challenges and Prospects by Kang, S. M., Tang, Q., Bluestone, J. A

“…The involvement of CD4+CD25+ regulatory T cells (Treg) in general immune homeostasis and protection from autoimmune syndromes is now well established…”
Get full text

Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial by Herold, K. C., Gitelman, S. E., Willi, S. M., Gottlieb, P. A., Waldron-Lynch, F., Devine, L., Sherr, J., Rosenthal, S. M., Adi, S., Jalaludin, M. Y., Michels, A. W., Dziura, J., Bluestone, J. A.

“…Aims/hypothesis Type 1 diabetes results from a chronic autoimmune process continuing for years after presentation. We tested whether treatment with teplizumab…”
Get full text

Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti‐LFA‐1 Antibody Efalizumab by Posselt, A. M., Bellin, M. D., Tavakol, M., Szot, G. L., Frassetto, L. A., Masharani, U., Kerlan, R. K., Fong, L., Vincenti, F. G., Hering, B. J., Bluestone, J. A., Stock, P. G.

“…The applicability of islet transplantation as treatment for type 1 diabetes is limited by renal and islet toxicities of currently available immunosuppressants…”
Get full text

COMPLEXITIES OF CD28/B7: CTLA-4 COSTIMULATORY PATHWAYS IN AUTOIMMUNITY AND TRANSPLANTATION by Salomon, Benoît, Bluestone, Jeffrey A

“…Recent advances in the understanding of T cell activation have led to new therapeutic approaches in the treatment of immunological disorders. One attractive…”
Get full text

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation by Earle, K.E., Tang, Q., Zhou, X., Liu, W., Zhu, S., Bonyhadi, M.L., Bluestone, J.A.

“…Regulatory T cells (Tregs) have been shown to be critical in the balance between autoimmunity and tolerance and have been implicated in several human…”
Get full text

Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis by Coquerelle, C, Oldenhove, G, Acolty, V, Denoeud, J, Vansanten, G, Verdebout, J-M, Mellor, A, Bluestone, J A, Moser, M

“…Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) has been shown to act as a negative regulator of T cell function and has been implicated in the regulation…”
Get more information

Is CTLA-4 a master switch for peripheral T cell tolerance? by Bluestone, J A

“…The CD28/CTLA-4 and B7 families of cell surface molecules regulate a complex pathway of T cell signals that profoundly affect peripheral T cell responses. On…”
Get full text

CD28/B7 SYSTEM OF T CELL COSTIMULATION by Lenschow, Deborah J, Walunas, Theresa L, Bluestone, Jeffrey A

“…T cells play a central role in the initiation and regulation of the immune response to antigen. Both the engagement of the TCR with MHC/Ag and a second signal…”
Get full text

Molecular Basis of T Cell Inactivation by CTLA-4 by Lee, Kyung-Mi, Chuang, Ellen, Griffin, Matthew, Khattri, Roli, Hong, David K., Zhang, Weiguo, Straus, David, Samelson, Lawrence E., Thompson, Craig B., Bluestone, Jeffrey A.

“…CTLA-4, a negative regulator of T cell function, was found to associate with the T cell receptor (TCR) complex ζ chain in primary T cells. The association of…”
Get full text

Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants by Chandran, S., Tang, Q., Sarwal, M., Laszik, Z. G., Putnam, A. L., Lee, K., Leung, J., Nguyen, V., Sigdel, T., Tavares, E. C., Yang, J. Y. C., Hellerstein, M., Fitch, M., Bluestone, J. A., Vincenti, F.

“…Early subclinical inflammation in kidney transplants is associated with later graft fibrosis and dysfunction. Regulatory T cells (Tregs) can reverse…”
Get full text

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice by Salomon, B, Rhee, L, Bour-Jordan, H, Hsin, H, Montag, A, Soliven, B, Arcella, J, Girvin, A M, Padilla, J, Miller, S D, Bluestone, J A

“…An increasing number of studies have documented the central role of T cell costimulation in autoimmunity. Here we show that the autoimmune diabetes-prone…”
Get full text

CTLA-4: a negative regulator of autoimmune disease by Karandikar, N J, Vanderlugt, C L, Walunas, T L, Miller, S D, Bluestone, J A

“…CTLA-4, a CD28 homologue expressed on activated T cells, binds with high affinity to the CD28 ligands, B7-1 (CD80) and B7-2 (CD86). This study was designed to…”
Get full text

Evidence for Functional Relevance of CTLA-4 in Ultraviolet-Radiation-Induced Tolerance by Schwarz, Agatha, Beissert, Stefan, Grosse-Heitmeyer, Karin, Gunzer, Matthias, Bluestone, Jeffrey A, Grabbe, Stephan, Schwarz, Thomas

“…Hapten sensitization through UV-exposed skin induces hapten-specific tolerance that can be adoptively transferred by injecting T lymphocytes into naive…”
Get full text

Identification of a Monoclonal Antibody Specific for a Murine T3 Polypeptide by Leo, Oberdan, Foo, Michele, Sachs, David H., Samelson, Lawrence E., Bluestone, Jeffrey A.

“…A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The…”
Get full text

CD28 costimulation promotes the production of Th2 cytokines by Rulifson, IC, Sperling, AI, Fields, PE, Fitch, FW, Bluestone, JA

“…CD28 ligation augments TCR-mediated proliferation, IL-2 production, and T cell survival. However, the role of CD28 costimulation in T cell differentiation…”
Get full text

Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice by MOKYR, M. B, KALINICHENKO, T, GORELIK, L, BLUESTONE, J. A

“…CTLA-4 blockade has been shown by other investigators [D. R. Leach, et al., Science (Washington DC), 271: 1734-1736, 1996; and Y-F. Yang, et al., Cancer Res.,…”
Get full text

Expression and Functional Significance of an Additional Ligand For CTLA-4 by Lenschow, Deborah J., Su, Gloria Huei-Ting, Zuckerman, Linda A., Nabavi, Nasrin, Jellis, Cindy L., Gray, Gary S., Miller, Jim, Bluestone, Jeffrey A.

“…Effective T-cell activation requires antigen/major histocompatibility complex engagement by the T-cell receptor complex in concert with one or more…”
Get full text

Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation by Levisetti, MG, Padrid, PA, Szot, GL, Mittal, N, Meehan, SM, Wardrip, CL, Gray, GS, Bruce, DS, Thistlethwaite, JR, Jr, Bluestone, JA

“…Ag-specific T cell activation requires a CD28-mediated costimulatory interaction. This observation has suggested novel approaches to suppress donor-specific…”
Get full text