Search Results - "Bloxham, David"

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma by Anderson, Georgina S.F., Ballester-Beltran, Jose, Giotopoulos, George, Guerrero, Jose A., Surget, Sylvanie, Williamson, James C., So, Tsz, Bloxham, David, Aubareda, Anna, Asby, Ryan, Walker, Ieuan, Jenkinson, Lesley, Soilleux, Elizabeth J., Roy, James P., Teodósio, Ana, Ficken, Catherine, Officer-Jones, Leah, Nasser, Sara, Skerget, Sheri, Keats, Jonathan J., Greaves, Peter, Tai, Yu-Tzu, Anderson, Kenneth C., MacFarlane, Marion, Thaventhiran, James E., Huntly, Brian J.P., Lehner, Paul J., Chapman, Michael A.

“…The accessibility of cell surface proteins makes them tractable for targeting by cancer immunotherapy, but identifying suitable targets remains challenging…”
Get full text

Automated dry thawing of cryopreserved haematopoietic cells is not adversely influenced by cryostorage time, patient age or gender by Kilbride, Peter, Meneghel, Julie, Creasey, Giovanna, Masoudzadeh, Fatemeh, Drew, Tina, Creasey, Hannah, Bloxham, David, Morris, G John, Jestice, Kevin

“…Cell therapies are becoming increasingly widely used, and their production and cryopreservation should take place under tightly controlled GMP conditions, with…”
Get full text

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies by McKerrell, Thomas, Moreno, Thaidy, Ponstingl, Hannes, Bolli, Niccolo, Dias, João M.L., Tischler, German, Colonna, Vincenza, Manasse, Bridget, Bench, Anthony, Bloxham, David, Herman, Bram, Fletcher, Danielle, Park, Naomi, Quail, Michael A., Manes, Nicla, Hodkinson, Clare, Baxter, Joanna, Sierra, Jorge, Foukaneli, Theodora, Warren, Alan J., Chi, Jianxiang, Costeas, Paul, Rad, Roland, Huntly, Brian, Grove, Carolyn, Ning, Zemin, Tyler-Smith, Chris, Varela, Ignacio, Scott, Mike, Nomdedeu, Josep, Mustonen, Ville, Vassiliou, George S.

“…The diagnosis of hematologic malignancies relies on multidisciplinary workflows involving morphology, flow cytometry, cytogenetic, and molecular genetic…”
Get full text

Rapid response of biallelic BRAF V600E mutated hairy cell leukaemia to low dose vemurafenib by Follows, George A., Sims, Hannah, Bloxham, David M., Zenz, Thorsten, Hopper, Melanie A., Liu, Hongxiang, Bench, Anthony, Wright, Penny, van't Veer, Mars B., Scott, Mike A.

Get full text

High resolution melting analysis for detection of BRAF exon 15 mutations in hairy cell leukaemia and other lymphoid malignancies by Boyd, Elaine M., Bench, Anthony J., van ‘t Veer, Mars B., Wright, Penny, Bloxham, David M., Follows, George A., Scott, Mike A.

“…Summary The BRAF V600E mutation has recently been described in all cases of hairy cell leukaemia (HCL). We have developed and validated a rapid and sensitive…”
Get full text

Changes in helper lymphocyte chemokine receptor expression and elevation of IP-10 during acute respiratory syncytial virus infection in infants by Roe, Michael F. E., Bloxham, David M., Cowburn, Andrew S., O'Donnell, Diarmuid R.

“…To cite this article: Roe MFE, Bloxham DM, Cowburn AS, O’Donnell DR. Changes in helper lymphocyte chemokine receptor expression and elevation of IP‐10 during…”
Get full text

PML protein analysis using imaging flow cytometry by Grimwade, Lizz, Gudgin, Emma, Bloxham, David, Scott, Mike A, Erber, Wendy N

“…Acute promyelocytic leukaemia (APML) can be promptly diagnosed by detecting abnormal diffuse staining patterns of PML bodies in abnormal promyelocytes using…”
Get more information

Detection of cytoplasmic nucleophosmin expression by imaging flow cytometry by Grimwade, Lizz, Gudgin, Emma, Bloxham, David, Bottley, Graham, Vassiliou, George, Huntly, Brian, Scott, Mike A., Erber, Wendy N.

“…Mutations within the nucleophosmin NPM1 gene occur in approximately one‐third of cases of acute myeloid leukemia (AML). These mutations result in cytoplasmic…”
Get full text

Hairy cell leukemia - immunotargets and therapies by Basheer, Faisal, Bloxham, David M, Scott, Mike A, Follows, George A

“…Hairy cell leukemia (HCL) is an indolent low-grade B-cell lymphoproliferative disorder that is reasonably sensitive to standard first-line purine analog…”
Get full text

Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura by Bowles, Kristian M., Bloxham, David M., Perry, David J., Baglin, Trevor P.

“…Summary This study investigated whether differences occur between the impedance and immunofluorescence methods for platelet quantification in idiopathic…”
Get full text

The neuroendocrine stress response and severity of acute respiratory syncytial virus bronchiolitis in infancy by TASKER, Robert C, ROE, Michael F. E, BLOXHAM, David M, WHITE, Deborah K, ROSS-RUSSELL, Robert I, O'DONNELL, D. Roddy

“…Neuroendocrine hormones have profound effects on the immune system. The immune response is a major factor in the pathogenesis of acute respiratory syncytial…”
Get full text

Guidelines on the use of multicolour flow cytometry in the diagnosis of haematological neoplasms by Johansson, Ulrika, Bloxham, David, Couzens, Stephen, Jesson, Jennifer, Morilla, Ricardo, Erber, Wendy, Macey, Marion

Get full text

Changes in practice within a haematological malignancy diagnostic service: A 5‐year retrospective study by Tobin, Jake, Egan, Caoimhe, Bloxham, David, Gudgin, Emma J., Morris, Audrey, Martin‐Cabrera, Pedro, Raso‐Barnett, Livia, Staniforth, Joy, Manasse, Bridget, Simeoni, Ilenia, Cullen, Matthew, Godfrey, Anna L.

Get full text

European flow cytometry quality assurance guidelines for the diagnosis of primary immune deficiencies and assessment of immune reconstitution following B cell depletion therapies and transplantation by Kelleher, Peter, Greathead, Louise, Whitby, Liam, Brando, Bruno, Barnett, David, Bloxham, David, deTute, Ruth, Dunlop, Alan, Farren, Timothy, Francis, Sebastian, Payne, Daniel, Scott, Stuart, Snowden, John A, Sorour, Youssef, Stansfield, Emma, Virgo, Paul, Whitby, Alison

“…Over the last 15 years activity of diagnostic flow cytometry services have evolved from monitoring of CD4 T cell subsets in HIV-1 infection to screening for…”
Get full text

Diagnosis of coeliac disease by flow cytometry of intraepithelial lymphocytes: a new ‘gold’ standard? by Basu, Kaninika, Creasey, Hannah, Bruggemann, Nina, Stevens, Jennifer, Bloxham, David, Woodward, Jeremy Mark

“…ObjectiveThe analysis of intraepithelial lymphocytes (IELs) by flow cytometry of duodenal biopsies—the ‘IEL’ lymphogram—has been proposed as a diagnostic test…”
Get full text

Inter‐laboratory validation of a harmonized PNH flow cytometry assay by Payne, Daniel, Johansson, Ulrika, Bloxham, David, Couzens, Stephen, Carter, Anthony, Holtom, Pamela, Baker, Bronia, Hughes, Mark, Knill, Tara, Milne, Tim, Morilla, Alison, Morilla, Ricardo, O'Brien, David, Thomas, Lisa

“…Background A network comprising 11 laboratories aimed to consolidate PNH testing by developing and validating an assay guided by previous guidelines and…”
Get full text

Rapid response of biallelic BRAF V 600 E mutated hairy cell leukaemia to low dose vemurafenib by Follows, George A., Sims, Hannah, Bloxham, David M., Zenz, Thorsten, Hopper, Melanie A., Liu, Hongxiang, Bench, Anthony, Wright, Penny, van't Veer, Mars B., Scott, Mike A.

Get full text

Rapid Response of Biallelic BRAF V600E Hairy Cell Leukaemia to Low Dose Vemurafenib by Sims, Hannah, Bloxham, David, Creasey, Hannah, Bradford, Elaine, Liu, Hongxiang, Wright, Penny, Bench, Anthony, Hopper, Melanie A, van't Veer, Mars, Crawley, Charles, Scott, Mike, Follows, George

“…Abstract 4890 Following the recent report that identified the V600E BRAF mutation in Hairy Cell Leukaemia (HCL) (Tiacci et al NEJM 2011), we confirmed this…”
Get full text

Aggressive Transformation of Indolent T-Cell Large Granular Lymphocytic Leukaemia During Chemotherapy: A Case Report by Grigoropoulos, Nicholas F, Wright, Penny, Bench, Anthony, Manasse, Bridget, Grigoropoulos, Rowan, Bloxham, David, Scott, Mike, Du, Ming-Qing, Follows, George A

“…Abstract 4803 Very little literature is available on aggressive transformation of indolent T-cell large granular lymphocytic leukaemia (LGL). We present the…”
Get full text

The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients by Nangalia, Jyoti, Massie, Charles, Baxter, E Joanna, Nice, Francesca L, Gundem, Gunes, Wedge, David, Avezov, Edward, Li, Juan, Kollmann, Karoline, Kent, David G., Aziz, Athar, Godfrey, Anna L, Hinton, Jonathan, Martincorena, Inigo, Van Loo, Peter, Jones, Amy V, Guglielmelli, Paola, Tarpey, Patrick, Harding, Heather P, Fitzpatrick, John D, Goudie, Calum T, Ortmann, Christina A, Loughran, Stephen J, Raine, Keiran, Jones, David, Butler, Adam, Teague, Jon W, O'Meara, Sarah, McLaren, Stuart, Bianchi, Michele, Silber, Yvonne, Dimitropolou, Danai, Bloxham, David, Mudie, Laura J, Maddison, Mark, Robinson, Ben, Keohane, Clodagh, MacLean, Cathy, Hill, Kate, Orchard, Kim H., Tauro, Sudhir, Du, Ming-Qing, Greaves, Mel, Bowen, David, Huntly, Brian, Harrison, Claire N, Cross, Nicholas C.P., Ron, David, Vannucchi, Alessandro M, Papaemmanuil, Elli, Campbell, Peter J., Green, Anthony R

“…BCR-ABL negative myeloproliferative neoplasms (MPNs), such as polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF) are chronic myeloid…”
Get full text