Search Results - "Bloxham, Conor J."

A Meta-analysis on the Role of Children in Severe Acute Respiratory Syndrome Coronavirus 2 in Household Transmission Clusters by Zhu, Yanshan, Bloxham, Conor J, Hulme, Katina D, Sinclair, Jane E, Tong, Zhen Wei Marcus, Steele, Lauren E, Noye, Ellesandra C, Lu, Jiahai, Xia, Yao, Chew, Keng Yih, Pickering, Janessa, Gilks, Charles, Bowen, Asha C, Short, Kirsty R

“…Abstract The role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains highly controversial. To address this…”
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A Bitter Taste in Your Heart by Bloxham, Conor J, Foster, Simon R, Thomas, Walter G

“…The human genome contains ∼29 bitter taste receptors (T2Rs), which are responsible for detecting thousands of bitter ligands, including toxic and aversive…”
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Glycemic Variability in Diabetes Increases the Severity of Influenza by Marshall, Rebecca J, Armart, Pornthida, Hulme, Katina D, Chew, Keng Yih, Brown, Alexandra C, Hansbro, Philip M, Bloxham, Conor J, Flint, Melanie, Ronacher, Katharina, Bielefeldt-Ohmann, Helle, Gallo, Linda A, Short, Kirsty R

“…People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this…”
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Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia by Dill, Veronika, Kirmes, Kilian, Han, Jiaying, Klug, Melissa, Rosenbaum, Marc, Viggiani, Giacomo, von Scheidt, Moritz, List, Markus, Herhaus, Peter, Ruland, Jürgen, Bassermann, Florian, Laugwitz, Karl-Ludwig, Götze, Katharina S, Jost, Philipp J, Jilg, Stefanie, Bloxham, Conor J, Raake, Philip W J, Bernlochner, Isabell, Bongiovanni, Dario

“…Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased…”
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High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier by Hulme, Katina D, Yan, Limin, Marshall, Rebecca J, Bloxham, Conor J, Upton, Kyle R, Hasnain, Sumaira Z, Bielefeldt-Ohmann, Helle, Loh, Zhixuan, Ronacher, Katharina, Chew, Keng Yih, Gallo, Linda A, Short, Kirsty R

“…Diabetes mellitus is a known susceptibility factor for severe influenza virus infections. However, the mechanisms that underlie this susceptibility remain…”
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A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants by Hulme, Katina D, Karawita, Anjana C, Pegg, Cassandra, Bunte, Myrna Jm, Bielefeldt-Ohmann, Helle, Bloxham, Conor J, Van den Hoecke, Silvie, Setoh, Yin Xiang, Vrancken, Bram, Spronken, Monique, Steele, Lauren E, Verzele, Nathalie Aj, Upton, Kyle R, Khromykh, Alexander A, Chew, Keng Yih, Sukkar, Maria, Phipps, Simon, Short, Kirsty R

“…Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are…”
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Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection by Sinclair, Jane E., Bloxham, Conor J., Chiu, Han, Chew, Keng Yih, Russell, Jake, Yoshikawa, Yusuke, Bielefeldt-Ohmann, Helle, Steele, Lauren E., Hulme, Katina D., Verzele, Nathalie AJ, Noye, Ellesandra C., Wu, Melanie, Reichelt, Melissa E., Thomas, Walter G., Gallo, Linda A., Redd, Meredith A., Short, Kirsty R.

“…People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also…”
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Cardiac human bitter taste receptors contain naturally occurring variants that alter function by Bloxham, Conor J, Hulme, Katina D, Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L, O'Brien, Shannon L, Foster, Simon R, Short, Kirsty R, Furness, Sebastian G B, Reichelt, Melissa E, Niv, Masha Y, Thomas, Walter G

“…Bitter taste receptors (T2R) are a subfamily of G protein-coupled receptors that enable humans to detect aversive and toxic substances. The ability to discern…”
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Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients by Aoude, Lauren G, Wong, Bernadette Z Y, Bonazzi, Vanessa F, Brosda, Sandra, Walters, Shaun B, Koufariotis, Lambros T, Naeini, Marjan M, Pearson, John V, Oey, Harald, Patel, Kalpana, Bradford, Julia J, Bloxham, Conor J, Atkinson, Victoria, Law, Phillip, Strutton, Geoffrey, Bayley, Gerard, Yang, Samuel, Smithers, B Mark, Waddell, Nicola, Miles, Kenneth, Barbour, Andrew P

“…Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage…”
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The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons by Verzele, Nathalie A. J., Chua, Brendon Y., Law, Charity W., Zhang, Albert, Ritchie, Matthew E., Wightman, Oliver, Edwards, Isaac N., Hulme, Katina D., Bloxham, Conor J., Bielefeldt‐Ohmann, Helle, Trewella, Matthew W., Moe, Aung Aung Kywe, Chew, Keng Yih, Mazzone, Stuart B., Short, Kirsty R., McGovern, Alice E.

“…Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes orchestrating viral sensing and…”
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A High-Fat Diet Increases Influenza A Virus-Associated Cardiovascular Damage by Siegers, Jurre Y, Novakovic, Boris, Hulme, Katina D, Marshall, Rebecca J, Bloxham, Conor J, Thomas, Walter G, Reichelt, Mellissa E, Leijten, Lonneke, van Run, Peter, Knox, Karen, Sokolowski, Kamil A, Tse, Brian W C, Chew, Keng Yih, Christ, Angelika N, Howe, Greg, Bruxner, Timothy J C, Karolyi, Mario, Pawelka, Erich, Koch, Rebecca M, Bellmann-Weiler, Rosa, Burkert, Francesco, Weiss, Günter, Samanta, Romit J, Openshaw, Peter J M, Bielefeldt-Ohmann, Helle, van Riel, Debby, Short, Kirsty R

“…Abstract Background Influenza A virus (IAV) causes a wide range of extrarespiratory complications. However, the role of host factors in these complications of…”
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A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters by Zhu, Yanshan, Bloxham, Conor J, Hulme, Katina D, Sinclair, Jane E, Tong, Zhen Wei Marcus, Steele, Lauren E, Noye, Ellesandra C, Lu, Jiahai, Xia, Yao, Chew, Keng Yih, Pickering, Janessa, Gilks, Charles, Bowen, Asha C, Short, Kirsty R

“…The role of children in the spread of SARS-CoV-2 remains highly controversial. To address this issue, we performed a meta-analysis of the published literature…”
Get full text