Search Results - "Blowers, S D"

Use of precision-cut liver slices for studies of unscheduled DNA synthesis by Beamand, J A, Price, R J, Blowers, S D, Wield, P T, Cunninghame, M E, Lake, B G

“…Precision-cut liver slices were prepared from untreated and Aroclor 1254 (ARO)-treated male Sprague-Dawley rats with a Krumdieck tissue slicer. Liver slices…”
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Limited cancer bioassay to test a potential food chemical by Anderson, D, Blowers, S D

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An in vitro and an in vivo unscheduled DNA synthesis assay with a zinc oxide/hexachloroethane (Zn/HCE) smoke by Anderson, D, Blowers, S D, Marrs, T C, Rice, P

“…1. Since Zn/HCE smoke has been shown previously to be weakly positive in the Ames test, and negative in the bone marrow micronucleus assay, other assays…”
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The in vivo genotoxic properties of the nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine by Blowers, S D, Anderson, D

“…The N-nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine (APNG) was investigated for in vivo genotoxicity using the dominant lethal assay and the…”
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Genotoxic effects in peripheral blood and urine of workers exposed to low level benzene by Yardley-Jones, A, Anderson, D, Jenkinson, P C, Lovell, D P, Blowers, S D, Davies, M J

“…Blood samples were obtained from a population of refinery workers representing different age groups. Sixty six men with low average exposure to benzene and 33…”
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Effects of the nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine on Salmonella typhimurium TA100 in the host-mediated assay in mice by Blowers, S D, Brinkworth, M H, Anderson, D

“…The N-nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine (APNG) was examined for mutagenicity in the mouse host-mediated assay using Salmonella typhimurium…”
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Investigation by the Ames test of urine samples from rats exposed to methyl isocyanate by Anderson, D, Blowers, S D, Nemery, B

“…The objective of the present study was to assess the mutagenic potential of urine collected from rats exposed to MIC using the Salmonella /mammalian microsomal…”
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Chromosomal aberrations and sister chromatid exchanges in lymphocytes and urine mutagenicity of migraine patients: a comparison of chronic feverfew users and matched non-users by Anderson, D, Jenkinson, P C, Dewdney, R S, Blowers, S D, Johnson, E S, Kadam, N P

“…1. Thirty migraine patients who had taken the leaves, tablets or capsules of feverfew daily for more than 11 consecutive months were compared to 30 feverfew…”
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The effect of antioxidants on bleomycin treatment in in vitro and in vivo genotoxicity assays by Anderson, D, Basaran, N, Blowers, S D, Edwards, A J

“…Antioxidants are thought to be important in protecting against damage from active oxygen species. The effects of the antioxidant nutrients vitamins C and E…”
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Investigation of possible genetoxic effects of feverfew in migraine patients by Johnson, E S, Kadam, N P, Anderson, D, Jenkinson, P C, Dewdney, R S, Blowers, S D

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Studies on the mutagenicity of a zinc oxide-hexachloroethane smoke by Clode, S A, Riley, R A, Blowers, S D, Marrs, T C, Anderson, D

“…1. A suitable method has been developed for generating atmospheres of zinc oxide/hexachloroethane smoke (ZnHCE). 2. The smoke was investigated using the Ames…”
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Mutagenicity testing of imidazole and related compounds by Forster, R, Blowers, S D, Cinelli, S, Marquardt, H, Westendorf, J

“…Ames tests have been performed with imidazole and its principal metabolites, hydantoin and hydantoic acid. N-Acetyl-imidazole, a potential metabolite resulting…”
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A method for the detection of protein-bound mutagens in food by Ibe, F I, Blowers, S D, Anderson, D, Massey, R

“…To investigate the possible presence of protein-bound mutagens in food an analytical procedure has been devised in which the sample is enzymically hydrolysed,…”
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Studies of the metabolic bioactivation of n-nitrosopyrrolidine in the rat by Cottrell, R C, Blowers, S D, Walters, D G, Lake, B G, Purchase, R, Phillips, J C, Gangolli, S D

“…The metabolism of N-nitrosopyrrolidine (NPYR) to 4-hydroxybutanal (4-HB) (the first stable product of the putative alpha-hydroxylation pathway) and its…”
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The effects of S9 mix from rat oesophagus, salivary gland, and liver on the mutagenicity of the rat oesophageal carcinogen N-nitroso-N-methylaniline in the Salmonella typhimurium assay by Anderson, D, Blowers, S D, Craddock, V M

“…The present study examines the feasibility of using the Salmonella typhimurium plate-incorporation assay of Ames for detecting target-organ specificity with…”
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The mutagenic properties of N-nitrosopeptides in the Ames test by Challis, B C, Hopkins, A R, Milligan, J R, Massey, R C, Anderson, D, Blowers, S D

“…N-(N-Acetyl-L-prolyl)-N-nitrosoglycine (APNG) and N-(N-acetylvalyl)-N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the Salmonella/mammalian…”
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