Search Results - "Blough, Michael D"

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression by De Boeck, Astrid, Ahn, Bo Young, D’Mello, Charlotte, Lun, Xueqing, Menon, Shyam V., Alshehri, Mana M., Szulzewsky, Frank, Shen, Yaoqing, Khan, Lubaba, Dang, Ngoc Ha, Reichardt, Elliott, Goring, Kimberly-Ann, King, Jennifer, Grisdale, Cameron J., Grinshtein, Natalie, Hambardzumyan, Dolores, Reilly, Karlyne M., Blough, Michael D., Cairncross, J. Gregory, Yong, V. Wee, Marra, Marco A., Jones, Steven J. M., Kaplan, David R., McCoy, Kathy D., Holland, Eric C., Bose, Pinaki, Chan, Jennifer A., Robbins, Stephen M., Senger, Donna L.

“…Despite a deeper molecular understanding, human glioblastoma remains one of the most treatment refractory and fatal cancers. It is known that the presence of…”
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Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors by Ahmad, Shiekh Tanveer, Rogers, Alexandra D., Chen, Myra J., Dixit, Rajiv, Adnani, Lata, Frankiw, Luke S., Lawn, Samuel O., Blough, Michael D., Alshehri, Mana, Wu, Wei, Marra, Marco A., Robbins, Stephen M., Cairncross, J. Gregory, Schuurmans, Carol, Chan, Jennifer A.

“…Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma. Despite its cancer link, little is known of Cic’s function in the…”
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Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers by Yip, Stephen, Butterfield, Yaron S, Morozova, Olena, Chittaranjan, Suganthi, Blough, Michael D, An, Jianghong, Birol, Inanc, Chesnelong, Charles, Chiu, Readman, Chuah, Eric, Corbett, Richard, Docking, Rod, Firme, Marlo, Hirst, Martin, Jackman, Shaun, Karsan, Aly, Li, Haiyan, Louis, David N, Maslova, Alexandra, Moore, Richard, Moradian, Annie, Mungall, Karen L, Perizzolo, Marco, Qian, Jenny, Roldan, Gloria, Smith, Eric E, Tamura-Wells, Jessica, Thiessen, Nina, Varhol, Richard, Weiss, Samuel, Wu, Wei, Young, Sean, Zhao, Yongjun, Mungall, Andrew J, Jones, Steven JM, Morin, Gregg B, Chan, Jennifer A, Cairncross, J Gregory, Marra, Marco A

“…Oligodendroglioma is characterized by unique clinical, pathological, and genetic features. Recurrent losses of chromosomes 1p and 19q are strongly associated…”
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Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments by Shen, Yaoqing, Grisdale, Cameron J., Islam, Sumaiya A., Bose, Pinaki, Lever, Jake, Zhao, Eric Y., Grinshtein, Natalie, Ma, Yussanne, Mungall, Andrew J., Moore, Richard A., Lun, Xueqing, Senger, Donna L., Robbins, Stephen M., Wang, Alice Yijun, MacIsaac, Julia L., Kobor, Michael S., Luchman, H. Artee, Weiss, Samuel, Chan, Jennifer A., Blough, Michael D., Kaplan, David R., Cairncross, J. Gregory, Marra, Marco A., Jones, Steven J. M.

“…Glioblastoma multiforme (GBM) is the most deadly brain tumor, and currently lacks effective treatment options. Brain tumor-initiating cells (BTICs) and…”
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On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells by Stechishin, Owen D, Luchman, H Artee, Ruan, Yibing, Blough, Michael D, Nguyen, Stephanie A, Kelly, John J, Cairncross, J Gregory, Weiss, Samuel

“…Glioblastoma multiforme (GBM) is characterized by an aggressive clinical course, therapeutic resistance, and striking molecular heterogeneity. GBM-derived…”
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ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts by Yuan, Alice L, Ricks, Christian B, Bohm, Alexandra K, Lun, Xueqing, Maxwell, Lori, Safdar, Shahana, Bukhari, Shazreh, Gerber, Amanda, Sayeed, Wajid, Bering, Elizabeth A, Pedersen, Haley, Chan, Jennifer A, Shen, Yaoqing, Marra, Marco, Kaplan, David R, Mason, Warren, Goodman, Lindsey D, Ezhilarasan, Ravesanker, Kaufmann, Ascher B, Cabral, Matthew, Robbins, Steve M, Senger, Donna L, Cahill, Daniel P, Sulman, Erik P, Cairncross, J Gregory, Blough, Michael D

“…Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in…”
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Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma by Blough, Michael D., Beauchamp, Desiree C., Westgate, Morgan R., Kelly, John J., Cairncross, J. Gregory

“…The most effective chemotherapeutic for glioblastoma (GBM) is the DNA alkylating agent temozolomide (TMZ). In a recent study by Hegi et al . benefit from TMZ…”
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p53 binding to the p21 promoter is dependent on the nature of DNA damage by Bodzak, Ewelina, Blough, Michael D., Lee, Patrick W.K., Hill, Richard

“…p53 is a tumor suppressor that integrates signals from different stress induced signalling pathways, regulates cell cycle arrest, senescence, apoptosis, and…”
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Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity by Chittaranjan, Suganthi, Chan, Susanna, Yang, Cindy, Yang, Kevin C, Chen, Vincent, Moradian, Annie, Firme, Marlo, Song, Jungeun, Go, Nancy E, Blough, Michael D, Chan, Jennifer A, Cairncross, J Gregory, Gorski, Sharon M, Morin, Gregg B, Yip, Stephen, Marra, Marco A

“…The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or…”
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Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity by LeBlanc, Véronique G., Trinh, Diane L., Aslanpour, Shaghayegh, Hughes, Martha, Livingstone, Dorothea, Jin, Dan, Ahn, Bo Young, Blough, Michael D., Cairncross, J. Gregory, Chan, Jennifer A., Kelly, John J.P., Marra, Marco A.

“…Glioblastomas (GBMs) are aggressive brain tumors characterized by extensive inter- and intratumor heterogeneity. Patient-derived models, such as organoids and…”
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In the beginning: PDGFA and the genesis of GBM by Blough, Michael D, Kumar, Mehul, Bose, Pinaki, Cairncross, J Gregory

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Lactate dehydrogenase A silencing in IDH mutant gliomas by Chesnelong, Charles, Chaumeil, Myriam M, Blough, Michael D, Al-Najjar, Mohammad, Stechishin, Owen D, Chan, Jennifer A, Pieper, Russell O, Ronen, Sabrina M, Weiss, Samuel, Luchman, H Artee, Cairncross, J Gregory

“…Mutations of the isocitrate dehydrogenase 1 and 2 gene (IDH1/2) were initially thought to enhance cancer cell survival and proliferation by promoting the…”
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Mitogen-induced defective mitosis transforms neural progenitor cells by Omairi, Hiba K, Grisdale, Cameron J, Meode, Mathieu, Bohm, Alexandra K, Black, Sophie, Adam, Nancy J, Chapman, Cassidy P, Maroilley, Tatiana, Kelly, John J, Tarailo-Graovac, Maja, Jones, Steven J M, Blough, Michael D, Cairncross, John Gregory

“…Abstract Background Chromosome instability (CIN) with recurrent copy number alterations is a feature of many solid tumors, including glioblastoma (GBM), yet…”
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An in vivo patient-derived model of endogenous IDH1-mutant glioma by Luchman, H Artee, Stechishin, Owen D, Dang, N Ha, Blough, Michael D, Chesnelong, Charles, Kelly, John J, Nguyen, Stephanie A, Chan, Jennifer A, Weljie, Aalim M, Cairncross, J Gregory, Weiss, Samuel

“…Somatic mutations in the catalytic domain of isocitrate dehydrogenase (IDH) 1/2 and accumulation of the oncometabolite 2-hydroxyglutarate (2-HG) appear to be…”
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O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells by BLOUGH, Michael D, ZLATESCU, Magdalena C, CAIRNCROSS, J. Gregory

“…Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter (i.e., gene silencing) occurs in 40% to 50% of patients with glioblastoma and…”
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PARP inhibition suppresses the emergence of temozolomide resistance in a model system by Yuan, Alice L., Meode, Mathieu, Tan, Melanie, Maxwell, Lori, Bering, Elizabeth. A., Pedersen, Haley, Willms, Jacob, Liao, Jenny, Black, Sophie, Cairncross, J. Gregory, Blough, Michael D.

“…Introduction Temozolomide (TMZ) is a life prolonging DNA alkylating agent active against glioblastomas (GBM) in which the O6-methylguanine-DNA…”
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Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring by Chaumeil, Myriam M, Radoul, Marina, Najac, Chloé, Eriksson, Pia, Viswanath, Pavithra, Blough, Michael D, Chesnelong, Charles, Luchman, H Artee, Cairncross, J Gregory, Ronen, Sabrina M

“…Metabolic imaging of brain tumors using (13)C Magnetic Resonance Spectroscopy (MRS) of hyperpolarized [1-(13)C] pyruvate is a promising neuroimaging strategy…”
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A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes by Spence, Tara, Perotti, Christian, Sin-Chan, Patrick, Picard, Daniel, Wu, Wei, Singh, Anjali, Anderson, Colleen, Blough, Michael D, Cairncross, J Gregory, Lafay-Cousin, Lucie, Strother, Douglas, Hawkins, Cynthia, Narendran, Aru, Huang, Annie, Chan, Jennifer A

“…Embryonal tumor with multilayered rosettes (ETMR) is an aggressive central nervous system primitive neuroectodermal tumor (CNS-PNET) variant. ETMRs have…”
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Comparative genomic and genetic analysis of glioblastoma-derived brain tumor-initiating cells and their parent tumors by Davis, Brad, Shen, Yaoqing, Poon, Candice C, Luchman, H Artee, Stechishin, Owen D, Pontifex, Carly S, Wu, Wei, Kelly, John J, Blough, Michael D

“…Glioblastoma (GBM) is a fatal cancer that has eluded major therapeutic advances. Failure to make progress may reflect the absence of a human GBM model that…”
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Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells by Grinshtein, Natalie, Rioseco, Constanza C, Marcellus, Richard, Uehling, David, Aman, Ahmed, Lun, Xueqing, Muto, Osamu, Podmore, Lauren, Lever, Jake, Shen, Yaoqing, Blough, Michael D, Cairncross, Greg J, Robbins, Stephen M, Jones, Steven J, Marra, Marco A, Al-Awar, Rima, Senger, Donna L, Kaplan, David R

“…Glioblastoma (GBM) is the most lethal and aggressive adult brain tumor, requiring the development of efficacious therapeutics. Towards this goal, we screened…”
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