Influence of individual differences in disease perception on consumer response to direct-to-consumer genomic testing
Individuals who undergo multiplex direct‐to‐consumer (DTC) genomic testing receive genetic risk results for multiple conditions. To date, research has not investigated the influence of individual differences in disease perceptions among consumers on testing outcomes. A total of 2037 participants rec...
Saved in:
| Published in: | Clinical genetics Vol. 87; no. 3; pp. 225 - 232 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Blackwell Publishing Ltd
01-03-2015
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Individuals who undergo multiplex direct‐to‐consumer (DTC) genomic testing receive genetic risk results for multiple conditions. To date, research has not investigated the influence of individual differences in disease perceptions among consumers on testing outcomes. A total of 2037 participants received DTC genomic testing and completed baseline and follow‐up surveys assessing disease perceptions and health behaviors. Participants were asked to indicate their most feared disease of those tested. Perceived seriousness and controllability of the disease via lifestyle or medical intervention were assessed. Participants most frequently reported heart attack (19.1%) and Alzheimer's disease (18.6%) as their most feared disease. Perceived seriousness and control over the feared disease both influenced response to DTC genomic testing. Greater perceived seriousness and diminished perceived control were associated with higher, but not clinically significant levels of anxiety and distress. In some cases these associations were modified by genetic risk. No significant associations were observed for diet, exercise and screening behaviors. Individual differences in disease perceptions influence psychological outcomes following DTC genomic testing. Higher perceived seriousness may make a consumer more psychologically sensitive to test results and greater perceived control may protect against adverse psychological outcomes. Findings may inform development of educational and counseling services. |
|---|---|
| Bibliography: | ark:/67375/WNG-PLDZPCZW-Z NIH/NHGRI R21 - No. 1R21HG005747 NIH flagship Clinical and Translational Science Award - No. 5UL1RR025774; No. 8UL1 TR000109; No. 8UL1 TR001114 ArticleID:CGE12419 Scripps Genomic Medicine Division of Scripps Health Table S1. Descriptive statistics for outcome variables (N = 2037)Table S2. Conditions most commonly selected by participants as being of most concern (top five by gender)Table S3. Genetic risk distributions as a function of disease being reported as feared vs not being reported as fearedTable S4. Perceptions as a function of genetic risk among individuals who reported a disease as most fearedTable S5. Main effect model results. Impact of genetic risk, and perceived seriousness of most feared disease on behavioral or psychological outcomesTable S6. Interaction model results. Impact of genetic risk, perceived seriousness of most feared disease, and interaction between risk and seriousness on behavioral or psychological outcomesTable S7. Main effect model results. Impact of genetic risk and perceived control of the most feared disease on behavioral or psychological outcomesTable S8. Interaction model results. Impact of genetic risk, perceived control of most feared disease, and interaction between risk and control on behavioral/psychological outcomesTable S9. Descriptive statistics for screening tests (%)Table S10. Impact of genetic risk and perceived seriousness of most feared disease on completion of health screenings (main effect model only)Table S11. Impact of genetic risk and control of lifestyle changes of most feared disease on completion of health screenings (main effect models only)Table S12. Impact of participant's most feared disease, genetic risk and control of seeking medical attention of a disease severity on completing health screeningsFig. S1. Percentage of participants denoting the disease as their most feared disease.Fig. S2. Percentage of individuals who completed health screeners for the five most commonly selected feared diseases. Health screeners were not available for Alzheimer's disease and obesity. The Scripps Dickinson Fellowship Fund istex:CF748186B6D65B0BCE075212FE1ADA858876DF52 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0009-9163 1399-0004 |
| DOI: | 10.1111/cge.12419 |