Search Results - "Bloomfield, CD"

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes by Vardiman, James W., Thiele, Jüergen, Arber, Daniel A., Brunning, Richard D., Borowitz, Michael J., Porwit, Anna, Harris, Nancy Lee, Le Beau, Michelle M., Hellström-Lindberg, Eva, Tefferi, Ayalew, Bloomfield, Clara D.

“…Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology,…”
Get full text

Acute myeloid leukaemia by Khwaja, Asim, Bjorkholm, Magnus, Gale, Rosemary E., Levine, Ross L., Jordan, Craig T., Ehninger, Gerhard, Bloomfield, Clara D., Estey, Eli, Burnett, Alan, Cornelissen, Jan J., Scheinberg, David A., Bouscary, Didier, Linch, David C.

“…Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived from primitive haematopoietic stem cells or progenitor cells…”
Get full text

Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine by Blum, William, Garzon, Ramiro, Klisovic, Rebecca B, Schwind, Sebastian, Walker, Alison, Geyer, Susan, Liu, Shujun, Havelange, Violaine, Becker, Heiko, Schaaf, Larry, Mickle, Jon, Devine, Hollie, Kefauver, Cheryl, Devine, Steven M, Chan, Kenneth K, Heerema, Nyla A, Bloomfield, Clara D, Grever, Michael R, Byrd, John C, Villalona-Calero, Miguel, Croce, Carlo M, Marcucci, Guido

“…A phase II clinical trial with single-agent decitabine was conducted in older patients (≥60 years) with previously untreated acute myeloid leukemia (AML) who…”
Get full text

Cytogenetics in acute leukemia by Mrózek, Krzysztof, Heerema, Nyla A, Bloomfield, Clara D

“…Cytogenetic analyses in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have revealed a great number of non-random chromosome…”
Get full text

MicroRNA Fingerprints during Human Megakaryocytopoiesis by Garzon, Ramiro, Pichiorri, Flavia, Palumbo, Tiziana, Iuliano, Rodolfo, Cimmino, Amelia, Aqeilan, Rami, Volinia, Stefano, Bhatt, Darshna, Alder, Hansjuerg, Marcucci, Guido, Calin, George A., Liu, Chang-Gong, Bloomfield, Clara D., Andreeff, Michael, Croce, Carlo M.

“…microRNAs are a highly conserved class of noncoding RNAs with important regulatory functions in proliferation, apoptosis, development, and differentiation. To…”
Get full text

Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia by Khalife, J, Radomska, H S, Santhanam, R, Huang, X, Neviani, P, Saultz, J, Wang, H, Wu, Y-Z, Alachkar, H, Anghelina, M, Dorrance, A, Curfman, J, Bloomfield, C D, Medeiros, B C, Perrotti, D, Lee, L J, Lee, R J, Caligiuri, M A, Pichiorri, F, Croce, C M, Garzon, R, Guzman, M L, Mendler, J H, Marcucci, G

“…High levels of microRNA-155 ( miR-155 ) are associated with poor outcome in acute myeloid leukemia (AML). In AML, miR-155 is regulated by NF-κB, the activity…”
Get full text

Revised Recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia by CHESON, Bruce D, BENNETT, John M, LOCOCCO, Francesco, WILLEMZE, Roel, BIONDI, Andrea, HIDDEMANN, Wolfgang, LARSON, Richard A, LÖWENBERG, Bob, SANZ, Miguel A, HEAD, David R, OHNO, Ryuzo, BLOOMFIELD, Clara D, KOPECKY, Kenneth J, BÜCHNER, Thomas, WILLMAN, Cheryl L, ESTEY, Elihu H, SCHIFFER, Charles A, DOEHNER, Hartmut, TALLMAN, Martin S, LISTER, T. Andrew

“…An International Working Group met to revise the diagnostic and response criteria for acute myelogenous leukemia originally published in 1990, as well as to…”
Get full text

Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia by Blum, William, Schwind, Sebastian, Tarighat, Somayeh S., Geyer, Susan, Eisfeld, Ann-Kathrin, Whitman, Susan, Walker, Alison, Klisovic, Rebecca, Byrd, John C., Santhanam, Ramasamy, Wang, Hongyan, Curfman, John P., Devine, Steven M., Jacob, Samson, Garr, Celia, Kefauver, Cheryl, Perrotti, Danilo, Chan, Kenneth K., Bloomfield, Clara D., Caligiuri, Michael A., Grever, Michael R., Garzon, Ramiro, Marcucci, Guido

“…We recently reported promising clinical activity for a 10-day regimen of decitabine in older AML patients; high miR-29b expression associated with clinical…”
Get full text

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein by Neviani, Paolo, Santhanam, Ramasamy, Trotta, Rossana, Notari, Mario, Blaser, Bradley W., Liu, Shujun, Mao, Hsiaoyin, Chang, Ji Suk, Galietta, Annamaria, Uttam, Ashwin, Roy, Denis C., Valtieri, Mauro, Bruner-Klisovic, Rebecca, Caligiuri, Michael A., Bloomfield, Clara D., Marcucci, Guido, Perrotti, Danilo

“…The oncogenic BCR/ABL kinase activity induces and maintains chronic myelogenous leukemia (CML). We show here that, in BCR/ABL-transformed cells and CML blast…”
Get full text

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461) by Byrd, John C., Mrózek, Krzysztof, Dodge, Richard K., Carroll, Andrew J., Edwards, Colin G., Arthur, Diane C., Pettenati, Mark J., Patil, Shivanand R., Rao, Kathleen W., Watson, Michael S., Koduru, Prasad R.K., Moore, Joseph O., Stone, Richard M., Mayer, Robert J., Feldman, Eric J., Davey, Frederick R., Schiffer, Charles A., Larson, Richard A., Bloomfield, Clara D.

“…We analyzed prospectively 1213 adults with de novo acute myeloid leukemia (AML) to ascertain the prognostic impact of cytogenetic abnormalities on complete…”
Get full text

Prognostic Factors and Outcome of Core Binding Factor Acute Myeloid Leukemia Patients With t(8;21) Differ From Those of Patients With inv(16): A Cancer and Leukemia Group B Study by MARCUCCI, Guido, MROZEK, Krzysztof, STERLING, Lisa J, VARDIMAN, James W, SCHIFFER, Charles A, CARROLL, Andrew J, LARSON, Richard A, BLOOMFIELD, Clara D, RUPPERT, Amy S, MAHARRY, Kati, KOLITZ, Jonathan E, MOORE, Joseph O, MAYER, Robert J, PETTENATI, Mark J, POWELL, Bayard L, EDWARDS, Colin G

“…Because both t(8;21) and inv(16) disrupt core binding factor (CBF) in acute myeloid leukemia (AML) and confer relatively favorable prognoses, these cytogenetic…”
Get full text

World Health Organization Classification of Neoplastic Diseases of the Hematopoietic and Lymphoid Tissues: Report of the Clinical Advisory Committee Meeting—Airlie House, Virginia, November 1997 by HARRIS, N. L, JAFFE, E. S, DIEBOLD, J, FLANDRIN, G, MULLER-HERMELINK, H. K, VARDIMAN, J, LISTER, T. A, BLOOMFIELD, C. D

“…The European Association of Hematopathologists and the Society for Hematopathology have developed a new World Health Organization (WHO) classification of…”
Get full text

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring by Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., Bloomfield, C. D., Lander, E. S.

“…Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or…”
Get full text

BAALC Expression and FLT3 Internal Tandem Duplication Mutations in Acute Myeloid Leukemia Patients With Normal Cytogenetics: Prognostic Implications by BALDUS, Claudia D, THIEDE, Christian, SOUCEK, Silke, BLOOMFIELD, Clara D, THIEL, Eckhard, EHNINGER, Gerhard

“…Evaluate the impact of BAALC (brain and acute leukemia, cytoplasmic), a gene whose expression has been associated with adverse outcome in acute myeloid…”
Get full text

All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol by Tallman, Martin S., Andersen, Janet W., Schiffer, Charles A., Appelbaum, Frederick R., Feusner, James H., Woods, William G., Ogden, Angela, Weinstein, Howard, Shepherd, Lois, Willman, Cheryl, Bloomfield, Clara D., Rowe, Jacob M., Wiernik, Peter H.

“…We previously reported a benefit for all-trans retinoic acid (ATRA) in both induction and maintenance therapy in patients with acute promyelocytic leukemia…”
Get full text

Clinical Significance of the BCR-ABL Fusion Gene in Adult Acute Lymphoblastic Leukemia: A Cancer and Leukemia Group B Study (8762) by Westbrook, Carol A., Hooberman, Arthur L., Spino, Cathie, Dodge, Richard K., Larson, Richard A., Davey, Frederick, Wurster-Hill, Doris H., Sobol, Robert E., Schiffer, Charles, Bloomfield, Clara D.

“…The Philadelphia (Ph1) chromosome, or its molecular counterpart, the BCR-ABL fusion gene, is a rare but important prognostic indicator in childhood acute…”
Get full text

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study by WHITMAN, Susan P, ARCHER, Kellie J, KOLITZ, Jonathan E, LARSON, Richard A, BLOOMFIELD, Clara D, CALIGIURI, Michael A, LAN FENG, BALDUS, Claudia, BECKNELL, Brian, CARLSON, Brian D, CARROLL, Andrew J, MROZEK, Krzysztof, VARDIMAN, James W, GEORGE, Stephen L

“…The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20-25% of adults with acute myeloid leukemia (AML). We studied 82 adults <60 years of age…”
Get full text

A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia by Metzeler, K H, Maharry, K, Kohlschmidt, J, Volinia, S, Mrózek, K, Becker, H, Nicolet, D, Whitman, S P, Mendler, J H, Schwind, S, Eisfeld, A-K, Wu, Y-Z, Powell, B L, Carter, T H, Wetzler, M, Kolitz, J E, Baer, M R, Carroll, A J, Stone, R M, Caligiuri, M A, Marcucci, G, Bloomfield, C D

“…Acute myeloid leukemia (AML) is hypothesized to be sustained by self-renewing leukemia stem cells (LSCs). Recently, gene expression signatures (GES) from…”
Get full text

Overexpression of the ETS-Related Gene, ERG, Predicts a Worse Outcome in Acute Myeloid Leukemia With Normal Karyotype: A Cancer and Leukemia Group B Study by MARCUCCI, Guido, BALDUS, Claudia D, BAER, Maria R, MOORE, Joseph O, PERROTTI, Danilo, CALIGIURI, Michael A, CARROLL, Andrew J, LARSON, Richard A, DE LA CHAPELLE, Albert, BLOOMFIELD, Clara D, RUPPERT, Amy S, RADMACHER, Michael D, MROZEK, Krzysztof, WHITMAN, Susan P, KOLITZ, Jonathan E, EDWARDS, Colin G, VARDIMAN, James W, POWELL, Bayard L

“…To test the prognostic significance of ETS-related gene (ERG) expression in cytogenetically normal primary acute myeloid leukemia (AML). Pretreatment blood…”
Get full text

Clinical features and gene- and microRNA-expression patterns in adult acute leukemia patients with t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3) by Bhatnagar, B, Blachly, J S, Kohlschmidt, J, Eisfeld, A-K, Volinia, S, Nicolet, D, Carroll, A J, Block, A W, Kolitz, J E, Stone, R M, Mrózek, K, Byrd, J C, Bloomfield, C D

Get full text