Search Results - "Bloom, Shoshana"
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Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases
Published in Nature communications (21-10-2021)“…Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based…”
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Bacterial delivery of therapeutic proteins to the nuclei of cancer cells
Published in Biotechnology and bioengineering (01-05-2023)“…Targeting nucleic targets with therapeutic proteins would enhance the treatment of hard‐to‐treat cancers. However, exogenous proteins are excluded from the…”
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Intracellular Salmonella delivery of an exogenous immunization antigen refocuses CD8 T cells against cancer cells, eliminates pancreatic tumors and forms antitumor immunity
Published in Frontiers in immunology (05-10-2023)“…Immunotherapies have shown great promise, but are not effective for all tumors types and are effective in less than 3% of patients with pancreatic ductal…”
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Intracellular delivery of oncolytic viruses with engineered Salmonella causes viral replication and cell death
Published in iScience (21-06-2024)“…As therapies, oncolytic viruses regress tumors and have the potential to induce antitumor immune responses that clear hard-to-treat and late-stage cancers…”
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Centering Digital Health Equity During Technology Innovation: Protocol for a Comprehensive Scoping Review of Evidence-Based Tools and Approaches
Published in JMIR research protocols (05-06-2024)“…In the rush to develop health technologies for the COVID-19 pandemic, the unintended consequence of digital health inequity or the inability of priority…”
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