Search Results - "Bloom, Michelle"

The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components by Stirling, Peter C, Bloom, Michelle S, Solanki-Patil, Tejomayee, Smith, Stephanie, Sipahimalani, Payal, Li, Zhijian, Kofoed, Megan, Ben-Aroya, Shay, Myung, Kyungjae, Hieter, Philip

“…Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of…”
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Cancer Therapy-Related Cardiac Dysfunction and Heart Failure: Part 1: Definitions, Pathophysiology, Risk Factors, and Imaging by Bloom, Michelle W, Hamo, Carine E, Cardinale, Daniela, Ky, Bonnie, Nohria, Anju, Baer, Lea, Skopicki, Hal, Lenihan, Daniel J, Gheorghiade, Mihai, Lyon, Alexander R, Butler, Javed

“…Advances in cancer therapy have resulted in significant improvement in long-term survival for many types of cancer but have also resulted in untoward side…”
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Dual diagnosis of autosomal dominant polycystic kidney disease and sickle cell disease in a teenage male by Stein, Quinn, Herman, Kathleen, Deyo, Jennifer, McDonough, Colleen, Bloom, Michelle S., Mansuri, Asifhusen

“…Background Sickle cell disease (SCD) and autosomal dominant polycystic kidney disease (ADPKD) are relatively common genetic conditions with considerable…”
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Cohesin Function in Cohesion, Condensation, and DNA Repair Is Regulated by Wpl1p via a Common Mechanism in Saccharomyces cerevisiae by Bloom, Michelle S, Koshland, Douglas, Guacci, Vincent

“…Cohesin tethers DNA to mediate sister chromatid cohesion, chromosome condensation, and DNA repair. How the cell regulates cohesin to perform these distinct…”
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B cell checkpoints in autoimmune rheumatic diseases by Rubin, Samuel J. S., Bloom, Michelle S., Robinson, William H.

“…B cells have important functions in the pathogenesis of autoimmune diseases, including autoimmune rheumatic diseases. In addition to producing autoantibodies,…”
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Interleukin 4 promotes anti-inflammatory macrophages that clear cartilage debris and inhibits osteoclast development to protect against osteoarthritis by von Kaeppler, Ericka P., Wang, Qian, Raghu, Harini, Bloom, Michelle S., Wong, Heidi, Robinson, William H.

“…Osteoarthritis (OA), the leading cause of joint failure, is characterized by breakdown of articular cartilage and remodeling of subchondral bone in synovial…”
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Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum by Chriswell, Meagan E, Lefferts, Adam R, Clay, Michael R, Hsu, Alex Ren, Seifert, Jennifer, Feser, Marie L, Rims, Cliff, Bloom, Michelle S, Bemis, Elizabeth A, Liu, Sucai, Maerz, Megan D, Frank, Daniel N, Demoruelle, M Kristen, Deane, Kevin D, James, Eddie A, Buckner, Jane H, Robinson, William H, Holers, V Michael, Kuhn, Kristine A

“…The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal immune responses in the initiation or perpetuation of the…”
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Neutralizing anti–IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease by Jarrell, Justin A., Baker, Matthew C., Perugino, Cory A., Liu, Hang, Bloom, Michelle S., Maehara, Takashi, Wong, Heidi H., Lanz, Tobias V., Adamska, Julia Z., Kongpachith, Sarah, Sokolove, Jeremy, Stone, John H., Pillai, Shiv S., Robinson, William H.

“…IgG4-related disease (IgG4-RD) is a fibroinflammatory condition involving loss of B-cell tolerance and production of autoantibodies. However, the relevant…”
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Cancer Therapy-Related Cardiac Dysfunction and Heart Failure: Part 2: Prevention, Treatment, Guidelines, and Future Directions by Hamo, Carine E, Bloom, Michelle W, Cardinale, Daniela, Ky, Bonnie, Nohria, Anju, Baer, Lea, Skopicki, Hal, Lenihan, Daniel J, Gheorghiade, Mihai, Lyon, Alexander R, Butler, Javed

“…Success with oncologic treatment has allowed cancer patients to experience longer cancer-free survival gains. Unfortunately, this success has been tempered by…”
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IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis by Wang, Qian, Lepus, Christin M, Raghu, Harini, Reber, Laurent L, Tsai, Mindy M, Wong, Heidi H, von Kaeppler, Ericka, Lingampalli, Nithya, Bloom, Michelle S, Hu, Nick, Elliott, Eileen E, Oliviero, Francesca, Punzi, Leonardo, Giori, Nicholas J, Goodman, Stuart B, Chu, Constance R, Sokolove, Jeremy, Fukuoka, Yoshihiro, Schwartz, Lawrence B, Galli, Stephen J, Robinson, William H

“…Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we…”
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Elevation of Donor-derived Cell-free DNA Before Biopsy-proven Rejection in Kidney Transplant by Bromberg, Jonathan S, Bunnapradist, Suphamai, Samaniego-Picota, Milagros, Anand, Sanjiv, Stites, Erik, Gauthier, Philippe, Demko, Zachary, Prewett, Adam, Armer-Cabral, Madeleine, Marshall, Kyle, Kaur, Navchetan, Bloom, Michelle S, Tabriziani, Hossein, Bhorade, Sangeeta, Cooper, Matthew

“…Standard-of-care biomarkers for renal allograft rejection are lagging indicators, signaling existing organ injury. This precludes early intervention, when…”
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The Clinical Utility of Genetic Testing in the Diagnosis and Management of Adults with Chronic Kidney Disease by Dahl, Neera K, Bloom, Michelle S, Chebib, Fouad T, Clark, Dinah, Westemeyer, Maggie, Jandeska, Sara, Zhang, Zhiji, Milo-Rasouly, Hila, Kolupaeva, Victoria, Marasa, Maddalena, Broumand, Varshasb, Fatica, Richard A, Raj, Dominic S, Demko, Zachary P, Marshall, Kyle, Punj, Sumit, Tabriziani, Hossein, Bhorade, Sangeeta, Gharavi, Ali G

“…Accurate diagnosis of a patient's underlying cause of CKD can influence management and ultimately overall health. The single-arm, interventional, prospective…”
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Heterozygous loss of function variants in IFT140 are associated with polycystic kidney disease by Clark, Dinah, Burns, Robert, Bloom, Michelle S., Lim, Karen Phaik Har, Li, Lili, Vincent, Lisa M., Xie, Jing, Xue, Yuan, Punj, Sumit

“…Autosomal dominant polycystic kidney disease (ADPKD) affects 1 in 1000 adults. Most cases result from causative PKD1 or PKD2 variants. HNF1B, GANAB and ALG9…”
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Heart failure with reduced ejection fraction by Bloom, Michelle W., Greenberg, Barry, Jaarsma, Tiny, Januzzi, James L., Lam, Carolyn S. P., Maggioni, Aldo P., Trochu, Jean-Noël, Butler, Javed

“…Heart failure is a global public health problem that affects more than 26 million people worldwide. The global burden of heart failure is growing and is…”
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Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis by Adamska, Julia Z, Zia, Amin, Bloom, Michelle S, Crofford, Leslie J, Furst, Daniel E, Goldmuntz, Ellen, Keyes-Elstein, Lynette, Mayes, Maureen D, McSweeney, Peter, Nash, Richard A, Pinckney, Ashley, Welch, Beverly, Love, Zelda Z, Sullivan, Keith M, Robinson, William

“…Myeloablative autologous haematopoietic stem cell transplant (HSCT) was recently demonstrated to provide significant benefit over cyclophosphamide (CYC) in the…”
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Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis by Brewer, R Camille, Lanz, Tobias V, Hale, Caryn R, Sepich-Poore, Gregory D, Martino, Cameron, Swafford, Austin D, Carroll, Thomas S, Kongpachith, Sarah, Blum, Lisa K, Elliott, Serra E, Blachere, Nathalie E, Parveen, Salina, Fak, John, Yao, Vicky, Troyanskaya, Olga, Frank, Mayu O, Bloom, Michelle S, Jahanbani, Shaghayegh, Gomez, Alejandro M, Iyer, Radhika, Ramadoss, Nitya S, Sharpe, Orr, Chandrasekaran, Sangeetha, Kelmenson, Lindsay B, Wang, Qian, Wong, Heidi, Torres, Holly L, Wiesen, Mark, Graves, Dana T, Deane, Kevin D, Holers, V Michael, Knight, Rob, Darnell, Robert B, Robinson, William H, Orange, Dana E

“…Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating…”
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RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis by Zhao, Xiaoyi, Younis, Shady, Shi, Hui, Hu, Shu, Zia, Amin, Wong, Heidi H., Elliott, Eileen E., Chang, Tiffany, Bloom, Michelle S., Zhang, Wei, Liu, Xiangyang, Lanz, Tobias Volker, Sharpe, Orr, Love, Zelda Z., Wang, Qian, Robinson, William H.

“…Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA by RNA-Seq…”
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A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase by Guacci, Vincent, Stricklin, Jeremiah, Bloom, Michelle S, Guō, Xuánzōng, Bhatter, Meghna, Koshland, Douglas

“…Cohesin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromosome segregation. Eco1p acetylates the cohesin subunit Smc3p…”
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Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis by James, Eddie A., Holers, V. Michael, Iyer, Radhika, Prideaux, E. Barton, Rao, Navin L., Rims, Cliff, Muir, Virginia S., Posso, Sylvia E., Bloom, Michelle S., Zia, Amin, Elliott, Serra E., Adamska, Julia Z., Ai, Rizi, Brewer, R. Camille, Seifert, Jennifer A., Moss, LauraKay, Barzideh, Saman, Demoruelle, M. Kristen, Striebich, Christopher C., Okamoto, Yuko, Sainbayar, Enkhtsogt, Crook, Alexandra A., Peterson, Ryan A., Vanderlinden, Lauren A., Wang, Wei, Boyle, David L., Robinson, William H., Buckner, Jane H., Firestein, Gary S., Deane, Kevin D.

“…Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in…”
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B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α production by Elliott, Serra E., Kongpachith, Sarah, Lingampalli, Nithya, Adamska, Julia Z., Cannon, Bryan J., Blum, Lisa K., Bloom, Michelle S., Henkel, Matthew, McGeachy, Mandy J., Moreland, Larry W., Robinson, William H.

“…Rheumatoid arthritis (RA) is characterized by the production of anti-citrullinated protein antibodies (ACPAs). To gain insights into the relationship between…”
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