Search Results - "Bloom, Kerry"

Cell Division: Single-Cell Physiology Reveals Secrets of Chromosome Condensation by Bloom, Kerry

“…Our understanding of higher order chromosome structure has been transformed through statistical mechanics-based computer simulations of polymer chains. A new…”
Get full text

Centromeric Heterochromatin: The Primordial Segregation Machine by Bloom, Kerry S

“…Centromeres are specialized domains of heterochromatin that provide the foundation for the kinetochore. Centromeric heterochromatin is characterized by…”
Get full text

Mitotic spindle form and function by Winey, Mark, Bloom, Kerry

“…The Saccharomyces cerevisiae mitotic spindle in budding yeast is exemplified by its simplicity and elegance. Microtubules are nucleated from a crystalline…”
Get full text

Point centromeres contain more than a single centromere-specific Cse4 (CENP-A) nucleosome by Lawrimore, Josh, Bloom, Kerry S, Salmon, E D

“…Cse4 is the budding yeast homologue of CENP-A, a modified histone H3 that specifies the base of kinetochores in all eukaryotes. Budding yeast is unique in…”
Get full text

R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast by Mishra, Prashant K, Chakraborty, Arijita, Yeh, Elaine, Feng, Wenyi, Bloom, Kerry S, Basrai, Munira A

“…R-loops, the byproduct of DNA-RNA hybridization and the displaced single-stranded DNA (ssDNA), have been identified in bacteria, yeasts, and other eukaryotic…”
Get full text

A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants by Hibshman, Jonathan D., Clark-Hachtel, Courtney M., Bloom, Kerry S., Goldstein, Bob

“…Desiccation kills most cells. Some proteins have been identified to help certain cells survive desiccation, but many protein protectants are likely to be…”
Get full text

Towards building a chromosome segregation machine by Bloom, Kerry, Joglekar, Ajit

“…All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 × 10 9 base pairs) of DNA…”
Get full text

Inferring Latent States and Refining Force Estimates via Hierarchical Dirichlet Process Modeling in Single Particle Tracking Experiments by Calderon, Christopher P, Bloom, Kerry

“…Understanding the basis for intracellular motion is critical as the field moves toward a deeper understanding of the relation between Brownian forces,…”
Get full text

The rDNA is biomolecular condensate formed by polymer–polymer phase separation and is sequestered in the nucleolus by transcription and R-loops by Lawrimore, Josh, Kolbin, Daniel, Stanton, John, Khan, Muznah, de Larminat, Solenn C, Lawrimore, Colleen, Yeh, Elaine, Bloom, Kerry

“…Abstract The nucleolus is the site of ribosome biosynthesis encompassing the ribosomal DNA (rDNA) locus in a phase separated state within the nucleus. In…”
Get full text

Publisher Correction: Adaptive partitioning of a gene locus to the nuclear envelope in Saccharomyces cerevisiae is driven by polymer-polymer phase separation by González, Lidice, Kolbin, Daniel, Trahan, Christian, Jeronimo, Célia, Robert, François, Oeffinger, Marlene, Bloom, Kerry, Michnick, Stephen W.

Get full text

Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage by Lawrimore, Josh, Barry, Timothy M, Barry, Raymond M, York, Alyssa C, Friedman, Brandon, Cook, Diana M, Akialis, Kristen, Tyler, Jolien, Vasquez, Paula, Yeh, Elaine, Bloom, Kerry

“…Chromatin exhibits increased mobility on DNA damage, but the biophysical basis for this behavior remains unknown. To explore the mechanisms that drive DNA…”
Get full text

How the kinetochore couples microtubule force and centromere stretch to move chromosomes by Suzuki, Aussie, Badger, Benjamin L., Haase, Julian, Ohashi, Tomoo, Erickson, Harold P., Salmon, Edward D., Bloom, Kerry

“…The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and…”
Get full text

DNA damage reduces heterogeneity and coherence of chromatin motions by Locatelli, Maëlle, Lawrimore, Josh, Lin, Hua, Sanaullah, Sarvath, Seitz, Clayton, Segall, Dave, Kefer, Paul, Salvador Moreno, Naike, Lietz, Benton, Anderson, Rebecca, Holmes, Julia, Yuan, Chongli, Holzwarth, George, Bloom, Kerry S, Liu, Jing, Bonin, Keith, Vidi, Pierre-Alexandre

“…Chromatin motions depend on and may regulate genome functions, in particular the DNA damage response. In yeast, DNA double-strand breaks (DSBs) globally…”
Get full text

Behavior of dicentric chromosomes in budding yeast by Cook, Diana, Long, Sarah, Stanton, John, Cusick, Patrick, Lawrimore, Colleen, Yeh, Elaine, Grant, Sarah, Bloom, Kerry

“…DNA double-strand breaks arise in vivo when a dicentric chromosome (two centromeres on one chromosome) goes through mitosis with the two centromeres attached…”
Get full text

FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A by Takada, Mamoru, Zhang, Weiguo, Suzuki, Aussie, Kuroda, Taruho S, Yu, Zhouliang, Inuzuka, Hiroyuki, Gao, Daming, Wan, Lixin, Zhuang, Ming, Hu, Lianxin, Zhai, Bo, Fry, Christopher J, Bloom, Kerry, Li, Guohong, Karpen, Gary H, Wei, Wenyi, Zhang, Qing

“…The centromere regulates proper chromosome segregation, and its dysfunction is implicated in chromosomal instability (CIN). However, relatively little is known…”
Get full text

Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring by Stephens, Andrew D, Haase, Julian, Vicci, Leandra, Taylor, 2nd, Russell M, Bloom, Kerry

“…Sister chromatid cohesion provides the mechanistic basis, together with spindle microtubules, for generating tension between bioriented chromosomes in…”
Get full text

Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability by Mishra, Prashant K, Au, Wei-Chun, Castineira, Pedro G, Ali, Nazrin, Stanton, John, Boeckmann, Lars, Takahashi, Yoshimitsu, Costanzo, Michael, Boone, Charles, Bloom, Kerry S, Thorpe, Peter H, Basrai, Munira A

“…Centromere ( ) identity is specified epigenetically by specialized nucleosomes containing evolutionarily conserved -specific histone H3 variant CENP-A (Cse4 in…”
Get full text

Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast by Mishra, Prashant K, Wood, Henry, Stanton, John, Au, Wei-Chun, Eisenstatt, Jessica R, Boeckmann, Lars, Sclafani, Robert A, Weinreich, Michael, Bloom, Kerry S, Thorpe, Peter H, Basrai, Munira A

“…Faithful chromosome segregation maintains chromosomal stability as errors in this process contribute to chromosomal instability (CIN), which has been observed…”
Get full text

Adaptive partitioning of a gene locus to the nuclear envelope in Saccharomyces cerevisiae is driven by polymer-polymer phase separation by González, Lidice, Kolbin, Daniel, Trahan, Christian, Jeronimo, Célia, Robert, François, Oeffinger, Marlene, Bloom, Kerry, Michnick, Stephen W.

“…Partitioning of active gene loci to the nuclear envelope (NE) is a mechanism by which organisms increase the speed of adaptation and metabolic robustness to…”
Get full text

Beyond the code: the mechanical properties of DNA as they relate to mitosis by Bloom, Kerry S

Get full text