Search Results - "Blood reviews"

Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management by Brudno, Jennifer N., Kochenderfer, James N.

“…Chimeric antigen receptor (CAR) T-cell therapy is an effective new treatment for hematologic malignancies. Two CAR T-cell products are now approved for…”
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Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges by Shallis, Rory M., Wang, Rong, Davidoff, Amy, Ma, Xiaomei, Zeidan, Amer M.

“…Acute myeloid leukemia (AML) is a malignant disorder of the bone marrow which is characterized by the clonal expansion and differentiation arrest of myeloid…”
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Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting by Jäger, Ulrich, Barcellini, Wilma, Broome, Catherine M., Gertz, Morie A., Hill, Anita, Hill, Quentin A., Jilma, Bernd, Kuter, David J., Michel, Marc, Montillo, Marco, Röth, Alexander, Zeerleder, Sacha S., Berentsen, Sigbjørn

“…Autoimmune hemolytic anemias (AIHAs) are rare and heterogeneous disorders characterized by the destruction of red blood cells through warm or cold antibodies…”
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Interplay between platelets and coagulation by Sang, Yaqiu, Roest, Mark, de Laat, Bas, de Groot, Philip G., Huskens, Dana

“…Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood vessels through clot formation. This regulated physiological…”
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Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system by Lazzaroni, Maria Grazia, Piantoni, Silvia, Masneri, Stefania, Garrafa, Emirena, Martini, Giuliana, Tincani, Angela, Andreoli, Laura, Franceschini, Franco

“…COVID-19 is a new pandemic, caused by Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-Cov2) infection and characterized by a broad spectrum of clinical…”
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Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes by England, James T., Abdulla, Alym, Biggs, Catherine M., Lee, Agnes Y.Y., Hay, Kevin A., Hoiland, Ryan L., Wellington, Cheryl L., Sekhon, Mypinder, Jamal, Shahin, Shojania, Kamran, Chen, Luke Y.C.

“…A subset of patients with severe COVID-19 develop profound inflammation and multi-organ dysfunction consistent with a “Cytokine Storm Syndrome” (CSS). In this…”
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Targeting MCL-1 in hematologic malignancies: Rationale and progress by Wei, Andrew H., Roberts, Andrew W., Spencer, Andrew, Rosenberg, Aaron Seth, Siegel, David, Walter, Roland B., Caenepeel, Sean, Hughes, Paul, McIver, Zach, Mezzi, Khalid, Morrow, Phuong Khanh, Stein, Anthony

“…Myeloid cell leukemia sequence 1 (MCL-1) is an antiapoptotic protein that plays a key role in promoting cell survival in multiple myeloma (MM), acute myeloid…”
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Platelet secretion: From haemostasis to wound healing and beyond by Golebiewska, Ewelina M, Poole, Alastair W

“…Abstract Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP…”
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Coagulation and anticoagulation in COVID-19 by Hadid, Tarik, Kafri, Zyad, Al-Katib, Ayad

“…COVID-19 has become a pandemic in the United States and worldwide. COVID-19-induced coagulopathy (CIC) is commonly encountered at presentation manifested by…”
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Fibrinolysis and the control of blood coagulation by Chapin, John C, Hajjar, Katherine A

“…Abstract Fibrin plays an essential role in hemostasis as both the primary product of the coagulation cascade and the ultimate substrate for fibrinolysis…”
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The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis by Liu, Nanyang, Zhang, Tingting, Ma, Lina, Zhang, Huiqing, Wang, Huichan, Wei, Wei, Pei, Hui, Li, Hao

“…The 2019 coronavirus disease (COVID-19) has become a global pandemic. Several studies report that ABO blood group polymorphism may be related to COVID-19…”
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Challenges of blood transfusions in β-thalassemia by Shah, Farrukh T., Sayani, Farzana, Trompeter, Sara, Drasar, Emma, Piga, Antonio

“…Patients with β-thalassemia major (BTM) require regular blood transfusions, supported by appropriate iron chelation therapy (ICT), throughout their life…”
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CAR-T – and a side order of IgG, to go? – Immunoglobulin replacement in patients receiving CAR-T cell therapy by Hill, Joshua A., Giralt, Sergio, Torgerson, Troy R., Lazarus, Hillard M.

“…The development and regulatory approval of chimeric antigen receptor T cell (CAR-T) therapies targeting the B-lineage surface antigen CD19 represents a major…”
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Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment by Giustozzi, Michela, Ehrlinder, Hanne, Bongiovanni, Dario, Borovac, Josip A., Guerreiro, Rui Azevedo, Gąsecka, Aleksandra, Papakonstantinou, Panteleimon E., Parker, William A.E.

“…Sepsis is a complex syndrome with a high incidence, increasing by 8.7% annually over the last 20 years. Coagulopathy is a leading factor associated with…”
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Blocking “don't eat me” signal of CD47-SIRPα in hematological malignancies, an in-depth review by Russ, Atlantis, Hua, Anh B., Montfort, William R., Rahman, Bushra, Riaz, Irbaz Bin, Khalid, Muhammad Umar, Carew, Jennifer S., Nawrocki, Steffan T., Persky, Daniel, Anwer, Faiz

“…Hematological malignancies express high levels of CD47 as a mechanism of immune evasion. CD47-SIRPα triggers a cascade of events that inhibit phagocytosis…”
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A review of FLT3 inhibitors in acute myeloid leukemia by Zhao, Jennifer C., Agarwal, Sonal, Ahmad, Hiba, Amin, Kejal, Bewersdorf, Jan Philipp, Zeidan, Amer M.

“…FLT3 mutations are the most common genetic aberrations found in acute myeloid leukemia (AML) and associated with poor prognosis. Since the discovery of FLT3…”
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New insights into iron deficiency and iron deficiency anemia by Camaschella, Clara

“…Abstract Recent advances in iron metabolism have stimulated new interest in iron deficiency (ID) and its anemia (IDA), common conditions worldwide. Absolute…”
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Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents by Lordan, Ronan, Tsoupras, Alexandros, Zabetakis, Ioannis

“…Platelets are central to inflammation-related manifestations of cardiovascular diseases (CVD) such as atherosclerosis. Platelet-activating factor (PAF),…”
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Hemophagocytic syndromes (HPS) including Hemophagocytic Lymphohistiocytosis (HLH) in Adults: A Systematic Scoping Review by Hayden, Anna, Park, Sujin, Giustini, Dean, Lee, Agnes Y.Y, Chen, Luke Y.C

“…Abstract Most knowledge of hemophagocytic syndromes (HPS) including hemophagocytic lymphohistiocytosis (HLH) is derived from pediatric studies; literature on…”
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Molecular Biomarkers in Acute Myeloid Leukemia by Prada-Arismendy, Jeanette, Ospina, Johanna Arroyave, Röthlisberger, Sarah

“…Abstract Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The pathophysiology of this disease is just beginning to be understood at…”
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