Search Results - "Blood, Quintin"

Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep by Moretta, Dafne, Papamatheakis, Demosthenes G, Morris, Daniel P, Giri, Paresh C, Blood, Quintin, Murray, Samuel, Ramzy, Marian, Romero, Monica, Vemulakonda, Srilakshmi, Lauw, Sidney, Longo, Lawrence D, Zhang, Lubo, Wilson, Sean M

“…Autonomic innervation of the pulmonary vasculature triggers vasomotor contractility predominately through activation of alpha-adrenergic receptors (α-ARs) in…”
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Depolarization-dependent contraction increase after birth and preservation following long-term hypoxia in sheep pulmonary arteries by Papamatheakis, Demosthenes G., Patel, Jay J., Blood, Quintin, Merritt, Travis T., Longo, Lawrence D., Wilson, Sean M.

“…Membrane depolarization is critical to pulmonary arterial (PA) contraction. Both L-type Ca2+ channels (CaL) and Rho-kinase are important signaling components…”
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Antenatal chronic hypoxia and L‐type Ca 2+ ‐dependent contractility of pulmonary arteries from fetal sheep (1089.6) by Brunelle, Alex, Blood, Quintin, Longo, Lawrence, Wilson, Sean

“…Abstract only Recently we and others have shown that K + ‐depolarization induced pulmonary arterial (PA) contraction is due to the combined activation of…”
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Antenatal chronic hypoxia and L‐type Ca2+‐dependent contractility of pulmonary arteries from fetal sheep (1089.6) by Brunelle, Alex, Blood, Quintin, Longo, Lawrence, Wilson, Sean

“…Recently we and others have shown that K+‐depolarization induced pulmonary arterial (PA) contraction is due to the combined activation of L‐type Ca2+ channels…”
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Chronic Hypoxia uncouples Ca 2+ and eNOS in bradykinin‐induced relaxation of Ovine pulmonary arteries by Blum‐Johnston, Carla M, Romero, Monica M, Wee, Chelsea, Blood, Quintin, Wilson, Rachael H, Blood, Arlin B., Francis, Michael, Taylor, Mark S, Longo, Lawrence D, Wilson, Sean M

“…Abstract only Bradykinin‐induced activation of the pulmonary endothelium triggers a rise in intracellular Ca 2+ , which activates a nitric oxide (NO)‐dependent…”
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Chronic hypoxia suppresses muscarinic‐induced contractility in ovine pulmonary arteries (1089.17) by Giang, Michael, Paez, Ricardo, Kim, Joon, Blood, Quintin, Longo, Lawerence, Wilson, Sean

“…Muscarinic acetylcholine receptor (mAChR)‐ arterial relaxation is often used to test for a functional endothelium, but some show it can cause constriction. The…”
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Chronic hypoxia increases the importance of BKCa channels to bradykinin‐mediated pulmonary vasodilation in fetal sheep (1089.18) by Blum‐Johnston, Carla, Wee, Chelsea, Blood, Quintin, Wilson, Rachael, Blood, Arlin, Longo, Lawerence, Wilson, Sean

“…Bradykinin‐induced activation of the pulmonary endothelium triggers a nitric oxide (NO)‐ signaling pathway. Pathway activation causes vasodilation and is…”
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mAChR Dependent Contraction of Pulmonary Arteries with Functional Endothelium from Chronically Hypoxic Fetal and Adult Sheep by Kim, Joon, Blood, Quintin, Longo, Lawrence D, Wilson, Sean M

“…Abstract only Muscarinic acetylcholine receptor (mAChR)‐dependent arterial relaxation is often used to test for a functional endothelium, where inability to…”
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Long-term hypoxia uncouples Ca 2+ and eNOS in bradykinin-mediated pulmonary arterial relaxation by Blum-Johnston, Carla, Thorpe, Richard B, Wee, Chelsea, Opsahl, Raechel, Romero, Monica, Murray, Samuel, Brunelle, Alexander, Blood, Quintin, Wilson, Rachael, Blood, Arlin B, Zhang, Lubo, Longo, Lawrence D, Pearce, William J, Wilson, Sean M

“…Bradykinin-induced activation of the pulmonary endothelium triggers a rise in intracellular Ca that activates nitric oxide (NO)-dependent vasorelaxation…”
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Developmental acceleration of bradykinin-dependent relaxation by prenatal chronic hypoxia impedes normal development after birth by Blum-Johnston, Carla, Thorpe, Richard B, Wee, Chelsea, Romero, Monica, Brunelle, Alexander, Blood, Quintin, Wilson, Rachael, Blood, Arlin B, Francis, Michael, Taylor, Mark S, Longo, Lawrence D, Pearce, William J, Wilson, Sean M

“…Bradykinin-induced activation of the pulmonary endothelium triggers nitric oxide production and other signals that cause vasorelaxation, including stimulation…”
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cGMP amplification of pulmonary arterial myocyte Ca2+ waves is preferentially impaired in high altitude‐induced hypoxic fetal sheep (1089.7) by Paez, Ricardo, Romero, Monica, Blood, Quintin, Osman, Noah, Manjunath, Chetas, Glasgow, Shane, Francis, Michael, Taylor, Mark, Longo, Lawerence, Wilson, Sean

“…High altitude is a risk factor in the development of pulmonary hypertension (PH). Treatment often includes the use of phosphodiesterase (PDE) inhibitors of…”
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cGMP amplification of pulmonary arterial myocyte Ca 2+ waves is preferentially impaired in high altitude‐induced hypoxic fetal sheep (1089.7) by Paez, Ricardo, Romero, Monica, Blood, Quintin, Osman, Noah, Manjunath, Chetas, Glasgow, Shane, Francis, Michael, Taylor, Mark, Longo, Lawerence, Wilson, Sean

“…Abstract only High altitude is a risk factor in the development of pulmonary hypertension (PH). Treatment often includes the use of phosphodiesterase (PDE)…”
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Development and long term hypoxia: Changes in ryanodine receptor expression in Ovine pulmonary arteries by Young, Kenneth L, Goyal, Ravi, Blood, Quintin, Wilson, Sean M, Longo, Lawrence D

“…Abstract only…”
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Long term hypoxia impairs ryanodine receptor function and regulation by cyclic nucleotides in immature and mature pulmonary arterial myocytes by Hough, Steven, Rubalcava, Monica, Manjunath, Chetas, Blood, Quintin, Longo, Lawrence D, Wilson, Sean M

“…Abstract only Calcium sparks are due to ryanodine receptor (RyR) activation and are intimate to local and global Ca 2+ signals in pulmonary arterial (PA)…”
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Effect of chronic perinatal hypoxia on the role of rho-kinase in pulmonary artery contraction in newborn lambs by Blood, Arlin B, Terry, Michael H, Merritt, Travis A, Papamatheakis, Demosthenes G, Blood, Quintin, Ross, Jonathon M, Power, Gordon G, Longo, Lawrence D, Wilson, Sean M

“…Exposure to chronic hypoxia during gestation predisposes infants to neonatal pulmonary hypertension, but the underlying mechanisms remain unclear. Here, we…”
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Bradykinin‐induced pulmonary vasorelaxation is modified by long term hypoxia and postnatal maturation in sheep by Blum‐Johnston, Carla, Blood, Quintin, Wee, Chelsea, Wilson, Rachael, Blood, Arlin B, Longo, Lawrence D, Wilson, Sean

“…Abstract only Endothelial activation is critical to pulmonary vasorelaxation during the fetal transition. Bradykinin (BK) relaxes vessels through…”
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Postnatal‐related changes in cAMP mediated pulmonary arterial relaxation and calcium signals persist following long term hypoxia in sheep by Paez, Ricardo, Rubalcava, Monica, Blood, Quintin, Hong, Sam, Francis, Michael, Taylor, Mark S, Longo, Lawrence D, Wilson, Sean M

“…Abstract only Phosphodiesterase (PDE) inhibition can elevate cAMP, dilate pulmonary arteries (PA) and is a therapeutic target for persistent pulmonary…”
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Underdeveloped bradykinin‐dependent vasorelaxation in immature pulmonary arteries from long term hypoxic sheep is not due to loss of cGMP signaling by Wee, Chelsea L, Blum‐Johnston, Carla, Blood, Quintin, Wilson, Rachael H, Blood, Arlin B, Longo, Lawrence D, Wilson, Sean M

“…Abstract only Endothelial dependent relaxation of the pulmonary vasculature is important during the fetal transition to breathing air. Our studies show…”
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Maternal Hypoxemia Suppresses Muscarinic Acetylcholine Receptor Dependent Contraction of Pulmonary Arteries from Fetal Sheep by Paez, Ricardo, Nguyen, Dan, Papamatheakis, Demosthenes, Kim, Joon, Blood, Quintin, Longo, Lawrence D, Wilson, Sean M

“…Abstract only Muscarinic acetylcholine (ACh) receptor (mAChR) activation relaxes arteries through endothelium‐dependent signaling pathways, yet ACh can…”
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Cyclic Nucleotides Cause Divergent Ryanodine Receptor Modulation in Pulmonary Arterial Myocytes from Immature Chronic Hypoxic Sheep by Rubalcava, Monica, Osman, Noah J, Blood, Quintin, Kim, Joon H, Longo, Lawrence D, Wilson, Sean M

“…Abstract only Calcium sparks are due to ryanodine receptor (RyR) activation and are intimate to local and global calcium signals in pulmonary arterial (PA)…”
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