Search Results - "Blons, Helene"

Mutations and Response to Epidermal Growth Factor Receptor Inhibitors by Pierre Laurent-Puig, Astrid Lievre, Hélène Blons

“…Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for a subgroup of patients with colorectal, lung, head…”
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Transplantation of Human Embryonic Stem Cell–Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction by Menasché, Philippe, Vanneaux, Valérie, Hagège, Albert, Bel, Alain, Cholley, Bernard, Parouchev, Alexandre, Cacciapuoti, Isabelle, Al-Daccak, Reem, Benhamouda, Nadine, Blons, Hélène, Agbulut, Onnik, Tosca, Lucie, Trouvin, Jean-Hugues, Fabreguettes, Jean-Roch, Bellamy, Valérie, Charron, Dominique, Tartour, Eric, Tachdjian, Gérard, Desnos, Michel, Larghero, Jérôme

“…In addition to scalability, human embryonic stem cells (hESCs) have the unique advantage of allowing their directed differentiation toward lineage-specific…”
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TP53, STK11 , and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma by Biton, Jérôme, Mansuet-Lupo, Audrey, Pécuchet, Nicolas, Alifano, Marco, Ouakrim, Hanane, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Goldwasser, François, Leroy, Karen, Goc, Jeremy, Wislez, Marie, Germain, Claire, Laurent-Puig, Pierre, Dieu-Nosjean, Marie-Caroline, Cremer, Isabelle, Herbst, Ronald, Blons, Hélène, Damotte, Diane

“…By unlocking antitumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non-small cell lung cancer,…”
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A comprehensive population-based study comparing the phenotype and genotype in a pretherapeutic screen of dihydropyrimidine dehydrogenase deficiency by Pallet, Nicolas, Hamdane, Salma, Garinet, Simon, Blons, Hélène, Zaanan, Aziz, Paillaud, Elena, Taieb, Julien, Laprevote, Olivier, Loriot, Marie-Anne, Narjoz, Céline

“…Background Pretherapeutic screening for dihydropyrimidine dehydrogenase (DPD) deficiency is recommended or required prior to the administration of…”
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Updated Prognostic Factors in Localized NSCLC by Garinet, Simon, Wang, Pascal, Mansuet-Lupo, Audrey, Fournel, Ludovic, Wislez, Marie, Blons, Hélène

“…Lung cancer is the most common cause of cancer mortality worldwide, and non-small cell lung cancer (NSCLC) represents 80% of lung cancer subtypes. Patients…”
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Lung Cancer That Harbors an HER2 Mutation: Epidemiologic Characteristics and Therapeutic Perspectives by Mazières, Julien, Peters, Solange, Lepage, Benoit, Cortot, Alexis B., Barlesi, Fabrice, Beau-Faller, Michéle, Besse, Benjamin, Blons, Hélène, Mansuet-Lupo, Audrey, Urban, Thierry, Moro-Sibilot, Denis, Dansin, Eric, Chouaid, Christos, Wislez, Marie, Diebold, Joachim, Felip, Enriqueta, Rouquette, Isabelle, Milia, Julie D., Gautschi, Oliver

“…HER2 mutations are identified in approximately 2%of non-small-cell lung cancers (NSCLC). There are few data available that describe the clinical course of…”
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Early Evaluation of Circulating Tumor DNA as Marker of Therapeutic Efficacy in Metastatic Colorectal Cancer Patients (PLACOL Study) by Garlan, Fanny, Laurent-Puig, Pierre, Sefrioui, David, Siauve, Nathalie, Didelot, Audrey, Sarafan-Vasseur, Nasrin, Michel, Pierre, Perkins, Geraldine, Mulot, Claire, Blons, Hélène, Taieb, Julien, Di Fiore, Frederic, Taly, Valerie, Zaanan, Aziz

“…Markers of chemotherapy efficacy in metastatic colorectal cancer (mCRC) are essential for optimization of treatment strategies. We evaluated the applicability…”
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Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors by Perrier, Alexandre, Didelot, Audrey, Laurent-Puig, Pierre, Blons, Hélène, Garinet, Simon

“…Immune checkpoint inhibitors (ICIs) have demonstrated to be highly efficient in treating solid tumors; however, many patients have limited benefits in terms of…”
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Early-Onset colorectal Cancer: From the laboratory to the clinic by Gandini, Annalice, Taieb, Julien, Blons, Hélène, Netter, Jeanne, Laurent-Puig, Pierre, Gallois, Claire

“…•By 2030, almost one quarter of rectal cancers will occur in people < 50 years.•Inheritance is responsible for 25 % of cases < 50 years and 33 % of…”
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Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients by Taly, Valerie, Pekin, Deniz, Benhaim, Leonor, Kotsopoulos, Steve K, Le Corre, Delphine, Li, Xinyu, Atochin, Ivan, Link, Darren R, Griffiths, Andrew D, Pallier, Karine, Blons, Hélène, Bouché, Olivier, Landi, Bruno, Hutchison, J Brian, Laurent-Puig, Pierre

“…Multiplex digital PCR (dPCR) enables noninvasive and sensitive detection of circulating tumor DNA with performance unachievable by current molecular-detection…”
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Base-Position Error Rate Analysis of Next-Generation Sequencing Applied to Circulating Tumor DNA in Non-Small Cell Lung Cancer: A Prospective Study by Pécuchet, Nicolas, Zonta, Eleonora, Didelot, Audrey, Combe, Pierre, Thibault, Constance, Gibault, Laure, Lours, Camille, Rozenholc, Yves, Taly, Valérie, Laurent-Puig, Pierre, Blons, Hélène, Fabre, Elizabeth

“…Circulating tumor DNA (ctDNA) is an approved noninvasive biomarker to test for the presence of EGFR mutations at diagnosis or recurrence of lung cancer…”
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Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial by Taieb, Julien, Prof, Tabernero, Josep, Prof, Mini, Enrico, Prof, Subtil, Fabien, PhD, Folprecht, Gunnar, MD, Van Laethem, Jean-Luc, Prof, Thaler, Josef, Prof, Bridgewater, John, MD, Petersen, Lone Nørgård, Prof, Blons, Hélène, PhD, Collette, Laurence, PhD, Van Cutsem, Eric, Prof, Rougier, Philippe, Prof, Salazar, Ramon, Prof, Bedenne, Laurent, Prof, Emile, Jean-François, Prof, Laurent-Puig, Pierre, Prof, Lepage, Come, Prof

“…Summary Background Since the 1990s, fluorouracil-based adjuvant chemotherapy has significantly reduced the risk of tumour recurrence in patients with stage III…”
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Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations by Zonta, Eleonora, Garlan, Fanny, Pécuchet, Nicolas, Perez-Toralla, Karla, Caen, Ouriel, Milbury, Coren, Didelot, Audrey, Fabre, Elizabeth, Blons, Hélène, Laurent-Puig, Pierre, Taly, Valérie

“…In cancer research, the accuracy of the technology used for biomarkers detection is remarkably important. In this context, digital PCR represents a highly…”
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Resistance mechanisms to osimertinib in EGFR-mutated advanced non-small-cell lung cancer: A multicentric retrospective French study by Mehlman, Camille, Cadranel, Jacques, Rousseau-Bussac, Gaelle, Lacave, Roger, Pujals, Anaïs, Girard, Nicolas, Callens, Céline, Gounant, Valérie, Théou-Anton, Nathalie, Friard, Sylvie, Trédaniel, Jean, Blons, Hélène, Dujon, Cécile, Duchemann, Boris, Schischmanoff, Pierre Olivier, Chinet, Thierry, Giroux Leprieur, Etienne

“…•We report resistance mechanisms on osimertinib in lung cancer patients.•We analyzed tissue and liquid biopsies collected at progression by NGS.•C797S EGFR…”
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Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT) by Barlesi, Fabrice, Dr Prof, Mazieres, Julien, Prof, Merlio, Jean-Philippe, Prof, Debieuvre, Didier, MD, Mosser, Jean, Prof, Lena, Hervé, MD, Ouafik, L'Houcine, Prof, Besse, Benjamin, MD, Rouquette, Isabelle, MD, Westeel, Virginie, Prof, Escande, Fabienne, MD, Monnet, Isabelle, MD, Lemoine, Antoinette, Prof, Veillon, Rémi, MD, Blons, Hélène, PharmD, Audigier-Valette, Clarisse, MD, Bringuier, Pierre-Paul, Prof, Lamy, Régine, MD, Beau-Faller, Michèle, MD, Pujol, Jean-Louis, Prof, Sabourin, Jean-Christophe, Prof, Penault-Llorca, Frédérique, Prof, Denis, Marc G, Prof, Lantuejoul, Sylvie, Prof, Morin, Franck, MSc, Tran, Quân, MSc, Missy, Pascale, PhD, Langlais, Alexandra, MSc, Milleron, Bernard, MD, Cadranel, Jacques, Prof, Soria, Jean-Charles, Prof, Zalcman, Gérard, Prof

“…Summary Background The molecular profiling of patients with advanced non-small-cell lung cancer (NSCLC) for known oncogenic drivers is recommended during…”
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Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer by Marisa, Laetitia, Blum, Yuna, Taieb, Julien, Ayadi, Mira, Pilati, Camilla, Le Malicot, Karine, Lepage, Côme, Salazar, Ramon, Aust, Daniela, Duval, Alex, Blons, Hélène, Taly, Valérie, Gentien, David, Rapinat, Audrey, Selves, Janick, Mouillet-Richard, Sophie, Boige, Valérie, Emile, Jean-François, de Reyniès, Aurélien, Laurent-Puig, Pierre

“…The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor…”
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Molecular markers and prediction of response to immunotherapy in non-small cell lung cancer, an update by Blons, Hélène, Garinet, Simon, Laurent-Puig, Pierre, Oudart, Jean-Baptiste

“…Immunotherapy represents one of the most promising therapeutic approaches in lung cancer, however 50% of lung cancer patients will not respond to this…”
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Prognostic value of circulating tumour DNA in metastatic pancreatic cancer patients: post-hoc analyses of two clinical trials by Pietrasz, Daniel, Wang-Renault, Shufang, Taieb, Julien, Dahan, Laetitia, Postel, Mathilde, Durand-Labrunie, Jerome, Le Malicot, Karine, Mulot, Claire, Rinaldi, Yves, Phelip, Jean-Marc, Doat, Solene, Blons, Hélène, de Reynies, Aurelien, Bachet, Jean-Baptiste, Taly, Valérie, Laurent-Puig, Pierre

“…Objective The prognostication of metastatic pancreatic adenocarcinoma (mPDAC) patients remains uncertain, mainly based on carbohydrate antigen 19-9 (CA19-9),…”
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Predictive Value of Soluble PD-1, PD-L1, VEGFA, CD40 Ligand and CD44 for Nivolumab Therapy in Advanced Non-Small Cell Lung Cancer: A Case-Control Study by Tiako Meyo, Manuela, Jouinot, Anne, Giroux-Leprieur, Etienne, Fabre, Elizabeth, Wislez, Marie, Alifano, Marco, Leroy, Karen, Boudou-Rouquette, Pascaline, Tlemsani, Camille, Khoudour, Nihel, Arrondeau, Jennifer, Thomas-Schoemann, Audrey, Blons, Hélène, Mansuet-Lupo, Audrey, Damotte, Diane, Vidal, Michel, Goldwasser, François, Alexandre, Jérôme, Blanchet, Benoit

“…A large interindividual variability has been observed in anti Programmed cell Death 1 (anti-PD1) therapies efficacy. The aim of this study is to assess the…”
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Peritoneal Tumour DNA in Peritoneal Fluid: Emerging Tool for Peritoneal Metastasis Detection by Mariani, Antoine, Blons, Hélène, Azais, Henri, Laurent-Puig, Pierre, Zaanan, Aziz, Gharbi, Amira

“…The prognostic significance of positive peritoneal cytology still varied between cancer types and geographical origin. However, because of the lack of…”
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