Search Results - "Blondelle, Sylvie E."

Optimization and high-throughput screening of antimicrobial peptides by Blondelle, Sylvie E, Lohner, Karl

“…While a well-established process for lead compound discovery in for-profit companies, high-throughput screening is becoming more popular in basic and applied…”
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N-acylated peptides derived from human lactoferricin perturb organization of cardiolipin and phosphatidylethanolamine in cell membranes and induce defects in Escherichia coli cell division by Zweytick, Dagmar, Japelj, Bostjan, Mileykovskaya, Eugenia, Zorko, Mateja, Dowhan, William, Blondelle, Sylvie E, Riedl, Sabrina, Jerala, Roman, Lohner, Karl

“…Two types of recently described antibacterial peptides derived from human lactoferricin, either nonacylated or N-acylated, were studied for their different…”
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Structural Features Governing the Activity of Lactoferricin-Derived Peptides That Act in Synergy with Antibiotics against Pseudomonas aeruginosa In Vitro and In Vivo by SANCHEZ-GOMEZ, Susana, JAPELJ, Bostjan, MARTINEZ DE TEJADA, Guillermo, JERALA, Roman, MORIYON, Ignacio, FERNANDEZ ALONSO, Mirian, LEIVA, José, BLONDELLE, Sylvie E, ANDRÄ, Jörg, BRANDENBURG, Klaus, LOHNER, Karl

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide by Andrä, Jörg, Lohner, Karl, Blondelle, Sylvie E, Jerala, Roman, Moriyon, Ignacio, Koch, Michel H J, Garidel, Patrick, Brandenburg, Klaus

“…Antibacterial peptide acylation, which mimics the structure of the natural lipopeptide polymyxin B, increases antimicrobial and endotoxin-neutralizing…”
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Experimental concepts for linking the biological activities of antimicrobial peptides to their molecular modes of action by Malanovic, Nermina, Marx, Lisa, Blondelle, Sylvie E., Pabst, Georg, Semeraro, Enrico F.

“…The search for novel compounds to combat multi-resistant bacterial infections includes exploring the potency of antimicrobial peptides and derivatives thereof…”
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Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides by Sánchez-Gómez, Susana, Lamata, Marta, Leiva, José, Blondelle, Sylvie E, Jerala, Roman, Andrä, Jörg, Brandenburg, Klaus, Lohner, Karl, Moriyón, Ignacio, Martínez-de-Tejada, Guillermo

“…Growing concerns about bacterial resistance to antibiotics have prompted the development of alternative therapies like those based on cationic antimicrobial…”
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Mixture-Based Synthetic Combinatorial Libraries by Houghten, Richard A, Pinilla, Clemencia, Appel, Jon R, Blondelle, Sylvie E, Dooley, Colette T, Eichler, Jutta, Nefzi, Adel, Ostresh, John M

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Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity by Zweytick, Dagmar, Pabst, Georg, Abuja, Peter M., Jilek, Alexander, Blondelle, Sylvie E., Andrä, Jörg, Jerala, Roman, Monreal, Daniel, Martinez de Tejada, Guillermo, Lohner, Karl

“…Increasing numbers of bacterial strains being resistant to conventional antibiotics emphasize the urgent need for new antimicrobial agents. One strategy is…”
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Design of model amphipathic peptides having potent antimicrobial activities by Blondelle, Sylvie E, Houghten, Richard A

“…Induced amphipathic alpha-helical conformations play an important role in the biological activity of peptides. By using reversed-phase high-performance liquid…”
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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery by Houghten, Richard A, Pinilla, Clemencia, Blondelle, Sylvie E, Appel, Jon R, Dooley, Colette T, Cuervo, Julio H

“…Existing methods for the synthesis and screening of large numbers of peptides are limited by their inability to generate and screen the requisite number…”
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Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV‐1 CTL epitope Gag77–85 by Boggiano, César, Moya, Rosa, Pinilla, Clemencia, Bihl, Florian, Brander, Christian, Sidney, John, Sette, Alessandro, Blondelle, Sylvie E.

“…Human immunodeficiency virus (HIV)‐specific cytotoxic T lymphocytes (CTL) play an important role in HIV infection. Given the viral genetic diversity, the…”
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Studies on Lactoferricin-derived Escherichia coli Membrane-active Peptides Reveal Differences in the Mechanism of N-Acylated Versus Nonacylated Peptides by Zweytick, Dagmar, Deutsch, Günter, Andrä, Jörg, Blondelle, Sylvie E., Vollmer, Ekkehard, Jerala, Roman, Lohner, Karl

“…To improve the low antimicrobial activity of LF11, an 11-mer peptide derived from human lactoferricin, mutant sequences were designed based on the defined…”
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Identification of a d-amino acid decapeptide HIV-1 entry inhibitor by Boggiano, César, Jiang, Shibo, Lu, Hong, Zhao, Qian, Liu, Shuwen, Binley, James, Blondelle, Sylvie E.

“…Entry of human immunodeficiency virus type 1 (HIV-1) virion into host cells involves three major steps, each being a potential target for the development of…”
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Antigenicity and immunogenicity of peptide analogues of a low affinity peptide of the human telomerase reverse transcriptase tumor antigen by Hernández, Javier, Schoeder, Kim, Blondelle, Sylvie E., Pons, Fancisco Garcia, Lone, Yu Chun, Simora, April, Langlade‐Demoyen, Pierre, Wilson, Darcy B., Zanetti, Maurizio

“…Human telomerase reverse transcriptase (hTRT) is a potential target for therapeutic vaccination against cancer. Therefore, it is critically important to…”
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Membrane curvature stress and antibacterial activity of lactoferricin derivatives by Zweytick, Dagmar, Tumer, Sabine, Blondelle, Sylvie E., Lohner, Karl

“…We have studied correlation of non-lamellar phase formation and antimicrobial activity of two cationic amphipathic peptides, termed VS1-13 and VS1-24 derived…”
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Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC: Insights into MHC Bias and Antigen Specificity by Maynard, Jennifer, Petersson, Karin, Wilson, Dianne H., Adams, Erin J., Blondelle, Sylvie E., Boulanger, Marty J., Wilson, Darcy B., Garcia, K.Christopher

“…T cell receptor crossreactivity with different peptide ligands and biased recognition of MHC are coupled features of antigen recognition that are necessary for…”
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An N-Methyl-D-Aspartate Receptor Channel Blocker with Neuroprotective Activity by Tai, Kwok-Keung, Blondelle, Sylvie E., Ostresh, John M., Houghten, Richard A., Montal, Mauricio

“…Excitotoxicity, resulting from sustained activation of glutamate receptors of the N-methyl-D-aspartate (NMDA) subtype, is considered to play a causative role…”
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Poly-(L-alanine) expansions form core β-sheets that nucleate amyloid assembly by Shinchuk, Leonid M., Sharma, Deepak, Blondelle, Sylvie E., Reixach, Natalia, Inouye, Hideyo, Kirschner, Daniel A.

“…Expansion to a total of 11–17 sequential alanine residues from the normal number of 10 in the polyadenine‐binding protein nuclear‐1 (PABPN1) results in…”
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Lipid-induced conformation and lipid-binding properties of cytolytic and antimicrobial peptides: determination and biological specificity by Blondelle, Sylvie E., Lohner, Karl, Aguilar, Marie-Isabel

“…While antimicrobial and cytolytic peptides exert their effects on cells largely by interacting with the lipid bilayers of their membranes, the influence of the…”
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Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relationship studies by Blondelle, Sylvie E, Lohner, Karl

“…In the race for supremacy, microbes are sprinting ahead. This warning by the World Health Organization clearly demonstrates that the spread of…”
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