Search Results - "Blomme, Eric A. G"

Toxicology Strategies for Drug Discovery: Present and Future by Blomme, Eric A. G, Will, Yvonne

“…Attrition due to nonclinical safety represents a major issue for the productivity of pharmaceutical research and development (R&D) organizations, especially…”
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Aldosterone induces a vascular inflammatory phenotype in the rat heart by Rocha, Ricardo, Rudolph, Amy E, Frierdich, Gregory E, Nachowiak, Denise A, Kekec, Beverly K, Blomme, Eric A G, McMahon, Ellen G, Delyani, John A

“…Vascular inflammation was examined as a potential mechanism of aldosterone-mediated myocardial injury in uninephrectomized rats receiving 1% NaCl-0.3% KCl to…”
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A Human Immunodeficiency Virus Protease Inhibitor Is a Novel Functional Inhibitor of Human Pregnane X Receptor by HEALAN-GREENBERG, Christine, WARING, Jeffrey F, KEMPF, Dale J, BLOMME, Eric A. G, TIRONA, Rommel G, KIM, Richard B

“…Drug-drug interactions involving induction of cytochrome P450 enzymes (P450s) can lead to loss of drug efficacy. Certain drugs, particularly those used to…”
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Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies by Rao, Mohan S, Van Vleet, Terry R, Ciurlionis, Rita, Buck, Wayne R, Mittelstadt, Scott W, Blomme, Eric A G, Liguori, Michael J

“…Gene expression profiling is a useful tool to predict and interrogate mechanisms of toxicity. RNA-Seq technology has emerged as an attractive alternative to…”
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Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells by LIGUORI, Michael J, BLOMME, Eric A. G, WARING, Jeffrey F

“…Primary human hepatocytes (PHH) are a main instrument in drug metabolism research and in the prediction of drug-induced phase I/II enzyme induction in humans…”
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Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers by Yang, Yi, Kowalkowski, Kenneth, Ciurlionis, Rita, Buck, Wayne R, Glaser, Keith B, Albert, Daniel H, Blomme, Eric A G

“…Cancer therapies targeting the vascular endothelial growth factor (VEGF) signaling pathway can lead to renal damage by disrupting the glomerular…”
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Novel Computational Approach to Predict Off-Target Interactions for Small Molecules by Rao, Mohan S, Gupta, Rishi, Liguori, Michael J, Hu, Mufeng, Huang, Xin, Mantena, Srinivasa R, Mittelstadt, Scott W, Blomme, Eric A G, Van Vleet, Terry R

“…Most small molecule drugs interact with unintended, often unknown, biological targets and these off-target interactions may lead to both preclinical and…”
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N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats by Yang, Yi, Ciurlionis, Rita, Kowalkowski, Kenneth, Marsh, Kennan C., Bracken, William M., Blomme, Eric A.G.

“…► N-vinylpyrrolidone dimer (VPD) is a novel experimental formulation excipient. ► It causes hepatocellular and thyroid gland hypertrophy in rats. ► It induces…”
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Preclinical species gene expression database: Development and meta-analysis by Krause, Caitlin, Suwada, Kinga, Blomme, Eric A G, Kowalkowski, Kenneth, Liguori, Michael J, Mahalingaiah, Prathap Kumar, Mittelstadt, Scott, Peterson, Richard, Rendino, Lauren, Vo, Andy, Van Vleet, Terry R

“…The evaluation of toxicity in preclinical species is important for identifying potential safety liabilities of experimental medicines. Toxicology studies…”
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Acute Molecular Markers of Rodent Hepatic Carcinogenesis Identified by Transcription Profiling by Kramer, Jeffrey A, Curtiss, Sandra W, Kolaja, Kyle L, Alden, Carl L, Blomme, Eric A. G, Curtiss, William C, Davila, Julio C, Jackson, Carmen J, Bunch, Roderick T

“…Currently, the only way to identify nongenotoxic hepatocarcinogens is through long-term repeat dose studies such as the 2 year rodent carcinogenicity assay…”
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Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation by Deng, Xiaomin, Stachlewitz, Robert F, Liguori, Michael J, Blomme, Eric A G, Waring, Jeffrey F, Luyendyk, James P, Maddox, Jane F, Ganey, Patricia E, Roth, Robert A

“…Idiosyncratic adverse drug reactions (IADRs) represent an important human health problem, yet animal models for preclinical prediction of these reactions are…”
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Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils by Waring, Jeffrey F, Liguori, Michael J, Luyendyk, James P, Maddox, Jane F, Ganey, Patricia E, Stachlewitz, Robert F, North, Colin, Blomme, Eric A G, Roth, Robert A

“…Idiosyncratic drug toxicity refers to toxic reactions occurring in a small subset of patients and usually cannot be predicted during preclinical or early…”
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Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts by Duan, W Rachel, Garner, Debra S, Williams, Steven D, Funckes-Shippy, Christie L, Spath, Iwona S, Blomme, Eric AG

“…The terminal deoxynucleotidyl transferase (TdT)‐mediated dUTP nick‐end labelling (TUNEL) technique has been extensively used for the detection and…”
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Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury by Deng, Xiaomin, Liguori, Michael J, Sparkenbaugh, Erica M, Waring, Jeffrey F, Blomme, Eric A G, Ganey, Patricia E, Roth, Robert A

“…Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is associated with idiosyncratic adverse drug reactions in humans. Previous studies revealed a…”
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Acyl glucuronide metabolites: Implications for drug safety assessment by Van Vleet, Terry R., Liu, Hong, Lee, Anthony, Blomme, Eric A.G.

“…Acyl glucuronides are important metabolites of compounds with carboxylic acid moieties and have unique properties that distinguish them from other phase 2…”
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Assessing renal function: Some significant improvements on the horizon by Blomme, Eric A G

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Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example by Liguori, Michael J, Ditewig, Amy C, Maddox, Jane F, Luyendyk, James P, Lehman-McKeeman, Lois D, Nelson, David M, Bhaskaran, Vasanthi M, Waring, Jeffrey F, Ganey, Patricia E, Roth, Robert A, Blomme, Eric A G

“…Idiosyncratic drug reactions (IDRs) are poorly understood, unpredictable, and not detected in preclinical studies. Although the cause of these reactions is…”
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Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats by Carr, Tracy L., Ciurlionis, Rita, Milicic, Ivan, Whitney, Katharine, Liguori, Michael J., Warder, Scott E., Strakhova, Marina I., Blomme, Eric A. G.

“…Dibromoacetic acid (DBAA), a by-product formed during disinfection of drinking water, alters spermatogenesis in rats through defective spermiation. The…”
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Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver by Pandiri, Arun R., Auerbach, Scott S., Stevens, Jim L., Blomme, Eric A. G.

“…Toxicogenomic technologies query the genome, transcriptome, proteome, and the epigenome in a variety of toxicological conditions. Due to practical…”
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Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals by Fricano, Meagan M, Ditewig, Amy C, Jung, Paul M, Liguori, Michael J, Blomme, Eric A G, Yang, Yi

“…Blood is an ideal tissue for the identification of novel genomic biomarkers for toxicity or efficacy. However, using blood for transcriptomic profiling…”
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