Search Results - "Blom, AB"

Gene Expression Analysis of Murine and Human Osteoarthritis Synovium Reveals Elevation of Transforming Growth Factor β–Responsive Genes in Osteoarthritis‐Related Fibrosis by Remst, D. F. G., Blom, A. B., Vitters, E. L., Bank, R. A., Berg, W. B., Blaney Davidson, E. N., Kraan, P. M.

“…Objective Synovial fibrosis is a major contributor to joint stiffness in osteoarthritis (OA). Transforming growth factor β (TGFβ), which is elevated in OA,…”
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Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis by Schelbergen, R F, Geven, E J, van den Bosch, M H J, Eriksson, H, Leanderson, T, Vogl, T, Roth, J, van de Loo, F A J, Koenders, M I, van der Kraan, P M, van den Berg, W B, Blom, A B, van Lent, P L E M

“…Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We…”
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Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis by Blom, Arjen B., van Lent, Peter L.E.M., Holthuysen, Astrid E.M., van der Kraan, Peter M., Roth, Johannes, van Rooijen, Nico, van den Berg, Wim B.

“…In human osteoarthritis (OA), various forms of pathology are observed. Besides cartilage damage and fibrosis, neogenesis of bone, osteophyte formation, also…”
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Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis by Mahler, EAM, Zweers, MC, van Lent, PL, Blom, AB, van den Hoogen, FH, van den Berg, WB, Roth, J, Vogl, T, Bijlsma, JWJ, van den Ende, CHM, den Broeder, AA

“…Objectives: To explore the association between S100A8/A9 serum levels with clinical and structural characteristics of patients with established knee, hip, or…”
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Analysis of binding sites on complement factor I required for its activity using artificial N-linked glycosylation by Sánchez Gallego, J.I., Groeneveld, T.G., Nilsson, S.C., Villoutreix, B.V., Blom, A.B.

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The Inhibitory Receptor FcγRII Reduces Joint Inflammation and Destruction in Experimental Immune Complex-Mediated Arthritides Not Only by Inhibition of FcγRI/III but Also by Efficient Clearance and Endocytosis of Immune Complexes by van Lent, Peter, Nabbe, Karin C., Boross, Peter, Blom, Arjen B., Roth, Johannes, Holthuysen, Astrid, Sloetjes, Annet, Verbeek, Sjef, van den Berg, Wim

“…Studies of FcγRII−/− mice identified the inhibitory function of this receptor in joint inflammation and cartilage destruction induced with immune complexes…”
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Increased FcγRII expression and aberrant tumour necrosis factor a production by mature dendritic cells from patients with active rheumatoid arthritis by RADSTAKE, T. R. D. J, BLOM, A. B, ADEMA, G. J, BARRERA, P, SLÖETJES, A. W, VAN GORSELEN, E. O. F, PESMAN, G. J, ENGELEN, L, TORENSMA, R, VAN DEN BERG, W. B, FIGDOR, C. G, VAN LENT, P. L. E. M

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High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcγR triggering by Radstake, T R D J, van Lent, P L E M, Pesman, G J, Blom, A B, Sweep, F G J, Rönnelid, J, Adema, G J, Barrera, P, van den Berg, W B

“…Objective: To assess whether DC from RA produce altered cytokine levels and whether this is regulated by triggering of Fc gamma receptors (FcγR). Methods: The…”
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Role of Activatory FcγRI and FcγRIII and Inhibitory FcγRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis by Van Lent, Peter L.E.M., Nabbe, Karin, Blom, Arjen B., Holthuysen, Astrid E.M., Sloetjes, Annet, Van De Putte, Leo B.A., Verbeek, Sjef, Van Den Berg, Wim B.

“…IgG-containing immune complexes, which are found in most RA joints, communicate with hematopoietic cells using three classes of Fc receptors(FcγRI, -II, -III)…”
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Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix by Happonen, K., Sjöberg, A.P., Heinegård, D., Blom, A.B.

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NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis by van Lent, Peter L E M, Nabbe, Karin C A M, Blom, Arjen B, Sloetjes, Annet, Holthuysen, Astrid E M, Kolls, Jay, Van De Loo, Fons A J, Holland, Steven M, Van Den Berg, Wim B

“…In previous studies we have found that FcgammaRI determines chondrocyte death and matrix metalloproteinase (MMP)-mediated cartilage destruction during…”
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Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA) by Blom, A B, van Lent, P L, van Vuuren, H, Holthuysen, A E, Jacobs, C, van de Putte, L B, van de Winkel, J G, van den Berg, W B

“…STATEMENT OF FINDINGS: We investigated the role of Fc gamma receptors (Fc gamma Rs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA…”
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Skewed balance in basal expression and regulation of activating v inhibitory Fcγ receptors in macrophages of collagen induced arthritis sensitive mice by Blom, A B, van Lent, P L E M, Holthuysen, A E M, Jacobs, C, van den Berg, W B

“…Background: Recently, it has been found that collagen type II arthritis susceptible mouse strains are hyperreactive to immune complexes (ICs), locally…”
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The inhibitory receptor FcγRII reduces joint inflammation in immune complex arthritis not only by inhibition of activatory FcγR but also by efficient clearance of immune complexes by van Lent, PL, Nabbe, K, Blom, AB, Holthuysen, AE, Verbeek, S, van den Berg, WB

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Crucial role of synovial lining macrophages in the promotion of transforming growth factor β–mediated osteophyte formation by Van Lent, P. L. E. M., Blom, A. B., Van Der Kraan, P., Holthuysen, A. E. M., Vitters, E., Van Rooijen, N., Smeets, R. L., Nabbe, K. C. A. M., Van Den Berg, W. B.

“…Objective To investigate in vivo and in vitro whether macrophages have an intermediate role in transforming growth factor β (TGFβ)–induced osteophyte…”
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Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase by Blom, Arjen B., Radstake, Timothy R. D. J., Holthuysen, Astrid E. M., Slöetjes, Annet W., Pesman, Gerard J., Sweep, Fred G. J., van de Loo, Fons A. J., Joosten, L. A. B., Barrera, Pilar, van Lent, Peter L. E. M., van den Berg, Wim B.

“…Objective To evaluate Fcγ receptor (FcγR) expression on synovial macrophages from rheumatoid arthritis (RA) patients and to determine whether this expression…”
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Coordinate expression of activating Fcγ receptors I and III and inhibiting Fcγ receptor type II in the determination of joint inflammation and cartilage destruction during immune complex–mediated arthritis by Nabbe, K. C. A. M., Blom, A. B., Holthuysen, A. E. M., Boross, P., Roth, J., Verbeek, S., Van Lent, P. L. E. M., Van Den Berg, W. B.

“…Objective To study the role of the activating Fcγ receptor types I and III (FcγRI and FcγRIII, respectively) and the inhibiting Fcγ receptor II (FcγRII) in…”
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Role of Fc receptor γ chain in inflammation and cartilage damage during experimental antigen‐induced arthritis by Van Lent, P. L. E. M., Van Vuuren, A. J., Blom, A. B., Holthuysen, A. E. M., Van De Putte, L. B. A., Van De Winkel, J. G. J., Van Den Berg, W. B.

“…Objective To study the role of Fc receptor (FcR) γ chain in inflammation and cartilage destruction during antigen‐induced arthritis (AIA). Methods FcR γ−/−…”
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IL-18 expression in synovial biopsies of patients with active rheumatoid arthritis is associated with enhanced levels of both IL-1 and TNFα by Joosten, LAB, Barrera, P, Lubberts, E, Blom, AB, Oppers-Walgreen, B, van den Bersselaa, LAM, van den Berg, WB

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Activating FcγRIII determines cartilage destruction during immune complex arthritis but not in the presence of T-cell immunity by van Lent, PLEM, Nabbe, K, Blom, AB, Holthuysen, AEM, Verbeek, JS, van den Berg, WB

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